Aim: To present our experiences with percutaneous nephrolithotomy performed in pediatric age groups within prior 3 years. Method: Percutaneous nephrolithotomy was performed in 25 renal units of 25 patients (14 boys, 11 girls) with mean age of 12.76 (5-16) years. Stones were localized at right side in 16 patients (64%) whereas at left side in 9 patients (36%). Of the stones, 12 were localized at renal pelvis, while 6 at lower pole, one at middle pole, and 6 at both renal pelvis and lower pole. In all patients, 18 F balloon dilation was performed to access kidney. Again, in all patients, 15 F rigid nephroscope was used for percutaneous nephrolithotomy. Results: Mean size of stones was 321.68±142.377 mm2 . Mean percutaneous nephrolithotomy time was 58.48±11.8 min. Mean duration of scopy use was 3.48±1.75 min. Balloon dilation was performed for access to kidney. Stone-free status was achieved in 21 patients (84%) on the postoperative day 1. Residual stones were detected in 4 patients (16%) after percutaneous nephrolithotomy. In one patient, it was found that broken tip of ureteral stent during extraction of stone by using forceps was migrated to lung. Two patients (8%) required blood replacement at postoperative period. Mean length of hospital stay was 2.76±1.6 days. Conclusion: PNL is a safe treatment modality with successful outcomes in the treatment of pediatric stone disease.