Objective: Our study aimed to demonstrate the epidemiological data of hepatitis Cvirus (HCV) and changes in its genotypic distribution which was observed in Adanain time. Materials and Methods: The data from 369 patients who were on follow up withthe diagnosis of chronic hepatitis C between January 1996 and March 2013, werereviewed retrospectively. The differences between the gender, age, and routes oftransmission among the HCV patients with different genotypes were reviewed.Changes in the mean age, gender, and virus genotypes of the patients in our regionby the years were evaluated. Results: Genotype 1 was identified in 289 (78.3%) patients, genotype 2 in 23(6.2%) patients, genotype 3 in 54 (14.6%) patients and genotype 4 was identifiedin 3 (0.8%) patients. When the genotypic distribution over the years was assessed,the rate of the patients with genotype 2 or 3 was 2.7% between 1996 and 2008, thisrate was observed to increase to 44% between 2012 and 2013. Sixty nine out of 77(89.6%) patients with genotype 2 or 3 were intravenous drug addicts. Conclusion: In our region intravenous drug use-related HCV infection wasincreased in recent years. Decrease in the mean age of the patients, higherprobability of occurrence among males and increased rates of genotype 2 and 3were associated with this reason.