Aim: This descriptive study was performed in order to determine the stress levels of primary infertile women due to infertility and the factors effecting their stress levels. Method: The research was conducted in an University Research Hospital gynecology polyclinic in Marmara Area. The sample consists of 118 primary infertile women. Data was collected by personal info form and fertility problem inventory (FPI) with face to face interview technique performed by researcher. The ethical permission of the research was granted by the University Medical Faculty Non-invasive Clinical Researches Ethical Committee. For the evaluation of data Mann-Whitney U Testi, t test; Kruskal-Wallis Test and Oneway ANOVA test was used. Findings: The age averages of women participating to the research was 29.88±6.33, infertility period average was 6.08±5.33. 49.1% of women were graduated from primary school and 73% were housewives. Global stress point average of women (171.53±33.61) was found to be higher compared to standard point average (134.4±33.8). It was determined that the highest point women got from fertility problem inventory sub dimensions was sub dimension of being parents (50.77±7.23). The education level, employment status, infertility period, sharing status of the problem with surrounding and reason of infertility being woman factor of women participating to the study was found to be effective on stress points. Conclusion: It was determined that women participating to the study had stress related eith being infertile and that the level of this stress was above the average stress levels. It is suggested that nurses working in this field should use their consultation skills more actively, plan psychosocial interventions and direct to psychosocial consultancy for women having high level of stress.