Evidence-based medicine (EBM) uses the best evidence carefully, clearly andwisely in making decisions about the care of individual patients. It started inthe early 1990s with the aim of implementing the best practices for patientsby integrating evidence and patient specificities into the clinical decision- making process. In present day, the approach of opinion based decision hasbeen replaced by one that prioritizes evidence instead, due to the instabilitiesand discrepancies between clinical applications and the difficulty of keepingup with the growing number of resources in medical literature that come outof the rapid progression of studies in medicine. EBMA involves formulatingan appropriate question regarding the problem encountered, surveying lit- erature to find the answer to the question, critically appraising the evidence,connecting the best evidence to the specificities of the patient in order tomake and implement decisions, and an incremental approach that evaluatesthe process. It requires doctors to be able to survey the literature, to haveknowledge in epidemiology and biostatistics, and to make decisions based onhis/her experience as well as patient specificities. This text provides a briefoverview of the definition of EBM, its history, the fundamental principles andstages of its application, the required skills to implement, the evidence pyra- mid and epidemiological research.