Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences

ŞEHİRLİ, İclal; ZENGİN TÜRKMEN, Aslı; Enginar, Nurhan; NURTEN, Asiye; ALLAHVERDİYEV, Oruc

Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences

Oruc ALLAHVERDİYEV, (İstanbul Üniversitesi, İstanbul,Tıp Fakültesi, Farmakoloji, Bölümü, İstanbul, Türkiye)

Aslı ZENGİN TÜRKMEN, (Yeni Yüzyıl Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiye)

Asiye NURTEN, (Yeni Yüzyıl Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiye)

İclal ŞEHİRLİ, (İstanbul Üniversitesi, İstanbul,Tıp Fakültesi, Farmakoloji, Bölümü, İstanbul, Türkiye)

Nurhan ENGİNAR (İstanbul Üniversitesi, İstanbul,Tıp Fakültesi, Farmakoloji, Bölümü, İstanbul, Türkiye)

Turkish Journal of Medical Sciences

6 0

Yıl: 2015 Cilt: 45 Sayı: 6 Sayfa Aralığı: 1380 - 1389 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences

Öz:

Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow somewithdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex- related differences in withdrawal signs and their suppression by clonidine. Materials and methods: Male and female rats and mice were administered with increasing doses of morphine twice daily at differentdosing intervals. Rats were given clonidine in drinking water (5 µg/mL). Spontaneous and naloxone-precipitated withdrawal signs andnovelty-induced grooming were evaluated. Results: Male rats and male and female rats displayed manifestations of morphine withdrawal at the end of 14-h and 24-h dosingintervals, respectively. Clonidine attenuated the severity of the withdrawal signs. Male but not female mice displayed withdrawal signsat the end of 12-h and 17-h dosing intervals. Female mice exhibited less pronounced naloxone-precipitated withdrawal syndrome.Grooming did not reflect a stress-like state in morphine-treated animals. Conclusion: These findings indicate intermittent morphine treatment-induced spontaneous withdrawal in rats and mice and sex- related differences in spontaneous and naloxone-precipitated withdrawal signs in mice. Since the treatment protocol closely parallelsthe drug use pattern in opioid addicts, further experiments are needed to clarify the stress associated with the treatment and the efficacyof sedatives.

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Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALLAHVERDİYEV O, ZENGİN TÜRKMEN A, NURTEN A, ŞEHİRLİ İ, Enginar N (2015). Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. , 1380 - 1389.
Chicago	ALLAHVERDİYEV Oruc,ZENGİN TÜRKMEN Aslı,NURTEN Asiye,ŞEHİRLİ İclal,Enginar Nurhan Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. (2015): 1380 - 1389.
MLA	ALLAHVERDİYEV Oruc,ZENGİN TÜRKMEN Aslı,NURTEN Asiye,ŞEHİRLİ İclal,Enginar Nurhan Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. , 2015, ss.1380 - 1389.
AMA	ALLAHVERDİYEV O,ZENGİN TÜRKMEN A,NURTEN A,ŞEHİRLİ İ,Enginar N Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. . 2015; 1380 - 1389.
Vancouver	ALLAHVERDİYEV O,ZENGİN TÜRKMEN A,NURTEN A,ŞEHİRLİ İ,Enginar N Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. . 2015; 1380 - 1389.
IEEE	ALLAHVERDİYEV O,ZENGİN TÜRKMEN A,NURTEN A,ŞEHİRLİ İ,Enginar N "Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences." , ss.1380 - 1389, 2015.
ISNAD	ALLAHVERDİYEV, Oruc vd. "Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences". (2015), 1380-1389.

APA	ALLAHVERDİYEV O, ZENGİN TÜRKMEN A, NURTEN A, ŞEHİRLİ İ, Enginar N (2015). Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. Turkish Journal of Medical Sciences, 45(6), 1380 - 1389.
Chicago	ALLAHVERDİYEV Oruc,ZENGİN TÜRKMEN Aslı,NURTEN Asiye,ŞEHİRLİ İclal,Enginar Nurhan Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. Turkish Journal of Medical Sciences 45, no.6 (2015): 1380 - 1389.
MLA	ALLAHVERDİYEV Oruc,ZENGİN TÜRKMEN Aslı,NURTEN Asiye,ŞEHİRLİ İclal,Enginar Nurhan Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. Turkish Journal of Medical Sciences, vol.45, no.6, 2015, ss.1380 - 1389.
AMA	ALLAHVERDİYEV O,ZENGİN TÜRKMEN A,NURTEN A,ŞEHİRLİ İ,Enginar N Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. Turkish Journal of Medical Sciences. 2015; 45(6): 1380 - 1389.
Vancouver	ALLAHVERDİYEV O,ZENGİN TÜRKMEN A,NURTEN A,ŞEHİRLİ İ,Enginar N Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences. Turkish Journal of Medical Sciences. 2015; 45(6): 1380 - 1389.
IEEE	ALLAHVERDİYEV O,ZENGİN TÜRKMEN A,NURTEN A,ŞEHİRLİ İ,Enginar N "Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences." Turkish Journal of Medical Sciences, 45, ss.1380 - 1389, 2015.
ISNAD	ALLAHVERDİYEV, Oruc vd. "Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences". Turkish Journal of Medical Sciences 45/6 (2015), 1380-1389.