The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

ÇELİK, Yunus; YILDIRIM, Nesligül; DOĞRU, MEHMET TOLGA; BEKMEZ ALYILMAZ, Sibel; SAYIN KOCAKAP, Derya Beyza; ÇABUK, Feryal; ŞİMŞEK, Vedat; ERDEM, Solmaz

The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

Derya Beyza Sayın KOCAKAP, (Kırıkkale Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kırıkkale, Türkiye)

Mehmet Tolga DOĞRU, (Kırıkkale Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kırıkkale, Türkiye)

Vedat ŞİMŞEK, (Kırıkkale Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kırıkkale, Türkiye)

Feryal ÇABUK, (Kırıkkale Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kırıkkale, Türkiye)

Nesligül YILDIRIM, (Kırıkkale Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kırıkkale, Türkiye)

Yunus ÇELİK, (Kırıkkale Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kırıkkale, Türkiye)

Sibel BEKMEZ ALYILMAZ, (Kırıkkale Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kırıkkale, Türkiye)

Solmaz ERDEM (Kırıkkale Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Kırıkkale, Türkiye)

The Anatolian Journal of Cardiology

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Yıl: 2016 Cilt: 16 Sayı: 3 Sayfa Aralığı: 175 - 182 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

Öz:

Objective: Coronary artery disease (CAD) is a common, complex, and progressive disorder characterized by the accumulation of lipids and fibrous elements in the arteries. It is one of the leading causes of death in industrialized nations. Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays an important role in the initiation and progression of atherosclerosis. Paraoxonase1 (PON1) is involved in lipid metabolism and is believed to protect LDL oxidation. In our study, we aimed to clarify the relationship between PON1 gene L55M polymorphism and the extent and severity of CAD.Methods: In total, 114 patients (54 males, mean age: 56.7±12.0 years; 60 females, mean age: 55.7±13.2 years) with stable angina or angina equivalent symptoms were enrolled in this prospective study. Cardiological evaluation was performed with electrocardiogram and transthoracic echocardiogram. The presence of hypertension, dyslipidemia, diabetes, and smoking status were ascertained. The patients were grouped according to their Gensini scores and gender. Genetic analysis of the PON1 gene L55M polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism.Results: We determined that the LL genotype was more prevalent in patients with Gensini score higher than or equal to 20 (p=0.026) and that this correlated with severe atherosclerotic coronary artery lesions in both gender groups, reaching a statistical significance in the female subjects (p=0.038).Conclusion: It was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SAYIN KOCAKAP D, DOĞRU M, ŞİMŞEK V, ÇABUK F, YILDIRIM N, ÇELİK Y, BEKMEZ ALYILMAZ S, ERDEM S (2016). The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. , 175 - 182.
Chicago	SAYIN KOCAKAP Derya Beyza,DOĞRU MEHMET TOLGA,ŞİMŞEK Vedat,ÇABUK Feryal,YILDIRIM Nesligül,ÇELİK Yunus,BEKMEZ ALYILMAZ Sibel,ERDEM Solmaz The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. (2016): 175 - 182.
MLA	SAYIN KOCAKAP Derya Beyza,DOĞRU MEHMET TOLGA,ŞİMŞEK Vedat,ÇABUK Feryal,YILDIRIM Nesligül,ÇELİK Yunus,BEKMEZ ALYILMAZ Sibel,ERDEM Solmaz The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. , 2016, ss.175 - 182.
AMA	SAYIN KOCAKAP D,DOĞRU M,ŞİMŞEK V,ÇABUK F,YILDIRIM N,ÇELİK Y,BEKMEZ ALYILMAZ S,ERDEM S The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. . 2016; 175 - 182.
Vancouver	SAYIN KOCAKAP D,DOĞRU M,ŞİMŞEK V,ÇABUK F,YILDIRIM N,ÇELİK Y,BEKMEZ ALYILMAZ S,ERDEM S The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. . 2016; 175 - 182.
IEEE	SAYIN KOCAKAP D,DOĞRU M,ŞİMŞEK V,ÇABUK F,YILDIRIM N,ÇELİK Y,BEKMEZ ALYILMAZ S,ERDEM S "The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender." , ss.175 - 182, 2016.
ISNAD	SAYIN KOCAKAP, Derya Beyza vd. "The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender". (2016), 175-182.

APA	SAYIN KOCAKAP D, DOĞRU M, ŞİMŞEK V, ÇABUK F, YILDIRIM N, ÇELİK Y, BEKMEZ ALYILMAZ S, ERDEM S (2016). The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. The Anatolian Journal of Cardiology, 16(3), 175 - 182.
Chicago	SAYIN KOCAKAP Derya Beyza,DOĞRU MEHMET TOLGA,ŞİMŞEK Vedat,ÇABUK Feryal,YILDIRIM Nesligül,ÇELİK Yunus,BEKMEZ ALYILMAZ Sibel,ERDEM Solmaz The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. The Anatolian Journal of Cardiology 16, no.3 (2016): 175 - 182.
MLA	SAYIN KOCAKAP Derya Beyza,DOĞRU MEHMET TOLGA,ŞİMŞEK Vedat,ÇABUK Feryal,YILDIRIM Nesligül,ÇELİK Yunus,BEKMEZ ALYILMAZ Sibel,ERDEM Solmaz The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. The Anatolian Journal of Cardiology, vol.16, no.3, 2016, ss.175 - 182.
AMA	SAYIN KOCAKAP D,DOĞRU M,ŞİMŞEK V,ÇABUK F,YILDIRIM N,ÇELİK Y,BEKMEZ ALYILMAZ S,ERDEM S The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. The Anatolian Journal of Cardiology. 2016; 16(3): 175 - 182.
Vancouver	SAYIN KOCAKAP D,DOĞRU M,ŞİMŞEK V,ÇABUK F,YILDIRIM N,ÇELİK Y,BEKMEZ ALYILMAZ S,ERDEM S The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. The Anatolian Journal of Cardiology. 2016; 16(3): 175 - 182.
IEEE	SAYIN KOCAKAP D,DOĞRU M,ŞİMŞEK V,ÇABUK F,YILDIRIM N,ÇELİK Y,BEKMEZ ALYILMAZ S,ERDEM S "The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender." The Anatolian Journal of Cardiology, 16, ss.175 - 182, 2016.
ISNAD	SAYIN KOCAKAP, Derya Beyza vd. "The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender". The Anatolian Journal of Cardiology 16/3 (2016), 175-182.