Öjenolün Farmakolojik ve Toksikolojik Özellikleri

NEJAD, Solmaz MOHAMMADI; BAŞARAN, Ayşe Nurşen; ÖZGÜNEŞ, Hilal

Öjenolün Farmakolojik ve Toksikolojik Özellikleri

Solmaz MOHAMMADI NEJAD, (Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey)

Hilal ÖZGÜNEŞ, (Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey)

Ayşe Nurşen BAŞARAN (Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey)

Turkish Journal of Pharmaceutical Sciences

111 9

Yıl: 2017 Cilt: 14 Sayı: 2 Sayfa Aralığı: 2099 - 7485 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Öjenolün Farmakolojik ve Toksikolojik Özellikleri

Öz:

Öjenol, Eugenia caryophyllata'nın yaprak ve tomurcuklarından elde edilen, karanfil yağının fenolik yapıdaki uçucu bir bileşiğidir. İlaç, gıda ve kozmetik endüstrisinde sınırlı miktarlarda kullanılan, çok sayıda ürünün işlevsel bir bileşenidir. Türevlerinin lokal antiseptik ve anestezik olarak tıpta kullanımı bulunmaktadır. Geniş aralıktaki farmakolojik etkileri arasında antimikrobiyal, antiinflamatuvar, analjezik, antioksidan ve antikanser etkiler yer almaktadır. Öjenol genel olarak güvenli bir bileşik olarak değerlendirilir ancak çok farklı uygulamaları ve yaygın kullanım alanları nedeniyle, toksisitesi son yıllarda ilgi odağı olmuştur. Öjenolün sitotoksisitesi ve genotoksisitesi konusundaki çalışmalar da yetersiz ve çelişkilidir. Bu derlemede öjenolün farmakolojik ve toksikolojik özellikleri tartışılacaktır.

Anahtar Kelime:

Konular: Biyoloji

Pharmacological and Toxicological Properties of Eugenol

Öz:

Eugenol is a volatile phenolic constituent of clove essential oil obtained from Eugenia caryophyllata buds and leaves. It is a functional ingredient of numerous products which have been used in the pharmaceutical, food and cosmetic industry in restricted concentrations. Its derivatives have been used in medicine as a local antiseptic and anesthetic. The wide range of eugenol activities includes antimicrobial, anti-inflammatory, analgesic and antioxidant. Although eugenol is considered safe as a product, due to the vast range of different applications and extensive use, there has been a great concern about its toxicity in recent years. However, studies about cytotoxicity and genotoxicity of eugenol are very limited and controversial. The pharmacological and toxicological properties of eugenol will be discussed in this review.

Anahtar Kelime:

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	NEJAD S, ÖZGÜNEŞ H, BAŞARAN A (2017). Öjenolün Farmakolojik ve Toksikolojik Özellikleri. , 2099 - 7485.
Chicago	NEJAD Solmaz MOHAMMADI,ÖZGÜNEŞ Hilal,BAŞARAN Ayşe Nurşen Öjenolün Farmakolojik ve Toksikolojik Özellikleri. (2017): 2099 - 7485.
MLA	NEJAD Solmaz MOHAMMADI,ÖZGÜNEŞ Hilal,BAŞARAN Ayşe Nurşen Öjenolün Farmakolojik ve Toksikolojik Özellikleri. , 2017, ss.2099 - 7485.
AMA	NEJAD S,ÖZGÜNEŞ H,BAŞARAN A Öjenolün Farmakolojik ve Toksikolojik Özellikleri. . 2017; 2099 - 7485.
Vancouver	NEJAD S,ÖZGÜNEŞ H,BAŞARAN A Öjenolün Farmakolojik ve Toksikolojik Özellikleri. . 2017; 2099 - 7485.
IEEE	NEJAD S,ÖZGÜNEŞ H,BAŞARAN A "Öjenolün Farmakolojik ve Toksikolojik Özellikleri." , ss.2099 - 7485, 2017.
ISNAD	NEJAD, Solmaz MOHAMMADI vd. "Öjenolün Farmakolojik ve Toksikolojik Özellikleri". (2017), 2099-7485.

APA	NEJAD S, ÖZGÜNEŞ H, BAŞARAN A (2017). Öjenolün Farmakolojik ve Toksikolojik Özellikleri. Turkish Journal of Pharmaceutical Sciences, 14(2), 2099 - 7485.
Chicago	NEJAD Solmaz MOHAMMADI,ÖZGÜNEŞ Hilal,BAŞARAN Ayşe Nurşen Öjenolün Farmakolojik ve Toksikolojik Özellikleri. Turkish Journal of Pharmaceutical Sciences 14, no.2 (2017): 2099 - 7485.
MLA	NEJAD Solmaz MOHAMMADI,ÖZGÜNEŞ Hilal,BAŞARAN Ayşe Nurşen Öjenolün Farmakolojik ve Toksikolojik Özellikleri. Turkish Journal of Pharmaceutical Sciences, vol.14, no.2, 2017, ss.2099 - 7485.
AMA	NEJAD S,ÖZGÜNEŞ H,BAŞARAN A Öjenolün Farmakolojik ve Toksikolojik Özellikleri. Turkish Journal of Pharmaceutical Sciences. 2017; 14(2): 2099 - 7485.
Vancouver	NEJAD S,ÖZGÜNEŞ H,BAŞARAN A Öjenolün Farmakolojik ve Toksikolojik Özellikleri. Turkish Journal of Pharmaceutical Sciences. 2017; 14(2): 2099 - 7485.
IEEE	NEJAD S,ÖZGÜNEŞ H,BAŞARAN A "Öjenolün Farmakolojik ve Toksikolojik Özellikleri." Turkish Journal of Pharmaceutical Sciences, 14, ss.2099 - 7485, 2017.
ISNAD	NEJAD, Solmaz MOHAMMADI vd. "Öjenolün Farmakolojik ve Toksikolojik Özellikleri". Turkish Journal of Pharmaceutical Sciences 14/2 (2017), 2099-7485.