Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women

Onat, Altan; Kaya, Ayşem; CAN, Günay; YÜKSEL, Hüsniye; HAYIROĞLU, Mert İ; Keskin, Muhammed

Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women

Altan ONAT, (İstanbul University)

Günay CAN, (İstanbul University)

Ayşem KAYA, (Biochemistry Section, Cardiology Institute, İstanbul University; İstanbul-Turkey)

Muhammed KESKİN, (Section of Cardiology, Siyami Ersek Center for Cardiovascular Surgery; İstanbul-Turkey)

Mert İ HAYIROĞLU, (Section of Cardiology, Siyami Ersek Center for Cardiovascular Surgery; İstanbul-Turkey)

Hüsniye YÜKSEL (İstanbul University)

The Anatolian Journal of Cardiology

1 0

Yıl: 2017 Cilt: 17 Sayı: 6 Sayfa Aralığı: 436 - 444 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women

Öz:

Objective: To assist the management strategy of individuals, we determined an algorithm for predicting the risk of coronary heart disease (CHD) death in Turkish adults with a high prevalence of metabolic syndrome (MetS).Methods: The risk of CHD death was estimated in 3054 middle-aged adults, followed over 9.08±4.2 years. Cox proportional hazard regression was used to predict risk. Discrimination was assessed using C-statistics.Results: CHD death was identified in 233 subjects. In multivariable analysis, the serum high-density lipoprotein-cholesterol (HDL-C) level was not predictive in men and the non-HDL-C level was not predictive in women. Age, presence of diabetes, systolic blood pressure >=160 mm Hg, smoking habit, and low physical activity were predictors in both sexes. The exclusion of coronary disease at baseline did not change the risk estimates materially. Using an algorithm of the 7 stated variables, individuals in the highest category of risk score showed a 19- to 50-fold higher spread in the absolute risk of death from CHD than those in the second lowest category. C-index of the model using age alone was as high as 0.774 in men and 0.836 in women (p<0.001 each), while the incorporation of 6 conventional risk factors contributed to a C-index of 0.058 in males and 0.042 in females.Conclusion: In a middle-aged population with prevalent MetS, men disclosed anticipated risk parameters (except for high HDL-C levels) as determinants of the risk of CHD death. On the other hand, serum non-HDL-C levels and moderate systolic hypertension were not relevant in women. The moderate contribution of conventional risk factors (beyond age) to the estimation of the risk of CHD death in women is consistent with the operation of autoimmune activation.

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Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	Onat A, CAN G, Kaya A, Keskin M, HAYIROĞLU M, YÜKSEL H (2017). Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. , 436 - 444.
Chicago	Onat Altan,CAN Günay,Kaya Ayşem,Keskin Muhammed,HAYIROĞLU Mert İ,YÜKSEL Hüsniye Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. (2017): 436 - 444.
MLA	Onat Altan,CAN Günay,Kaya Ayşem,Keskin Muhammed,HAYIROĞLU Mert İ,YÜKSEL Hüsniye Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. , 2017, ss.436 - 444.
AMA	Onat A,CAN G,Kaya A,Keskin M,HAYIROĞLU M,YÜKSEL H Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. . 2017; 436 - 444.
Vancouver	Onat A,CAN G,Kaya A,Keskin M,HAYIROĞLU M,YÜKSEL H Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. . 2017; 436 - 444.
IEEE	Onat A,CAN G,Kaya A,Keskin M,HAYIROĞLU M,YÜKSEL H "Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women." , ss.436 - 444, 2017.
ISNAD	Onat, Altan vd. "Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women". (2017), 436-444.

APA	Onat A, CAN G, Kaya A, Keskin M, HAYIROĞLU M, YÜKSEL H (2017). Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. The Anatolian Journal of Cardiology, 17(6), 436 - 444.
Chicago	Onat Altan,CAN Günay,Kaya Ayşem,Keskin Muhammed,HAYIROĞLU Mert İ,YÜKSEL Hüsniye Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. The Anatolian Journal of Cardiology 17, no.6 (2017): 436 - 444.
MLA	Onat Altan,CAN Günay,Kaya Ayşem,Keskin Muhammed,HAYIROĞLU Mert İ,YÜKSEL Hüsniye Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. The Anatolian Journal of Cardiology, vol.17, no.6, 2017, ss.436 - 444.
AMA	Onat A,CAN G,Kaya A,Keskin M,HAYIROĞLU M,YÜKSEL H Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. The Anatolian Journal of Cardiology. 2017; 17(6): 436 - 444.
Vancouver	Onat A,CAN G,Kaya A,Keskin M,HAYIROĞLU M,YÜKSEL H Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women. The Anatolian Journal of Cardiology. 2017; 17(6): 436 - 444.
IEEE	Onat A,CAN G,Kaya A,Keskin M,HAYIROĞLU M,YÜKSEL H "Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women." The Anatolian Journal of Cardiology, 17, ss.436 - 444, 2017.
ISNAD	Onat, Altan vd. "Algorithm for predicting CHD death risk in Turkish adults: conventional factors contribute only moderately in women". The Anatolian Journal of Cardiology 17/6 (2017), 436-444.