Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi

BÜYÜKAŞIK, Yahya; HAZNEDAROĞLU, İbrahim C.; ÖZCEBE, Osman İ.; Ozbek, Ugur; GOKER, ALI HAKAN; AKSU, SALIH; Sayınalp, Nilgün; HATIRNAZ NG, ÖZDEN; Aydın Sayitoglu, Muge; ÇATAL TATONYAN, Suzin; UZ, Burak; ERBILGIN, YÜCEL

Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi

Burak UZ, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Suzin ÇATAL TATONYAN, (İstanbul University, Institute for Experimental Medicine Research, Department of Genetics, İstanbul, Turkey)

Müge SAYİTOĞLU, (İstanbul University, Institute for Experimental Medicine Research, Department of Genetics, İstanbul, Turkey)

Yücel ERBİLGİN, (İstanbul University, Institute for Experimental Medicine Research, Department of Genetics, İstanbul, Turkey)

ÖZDEN HATIRNAZ NG, (İstanbul University, Institute for Experimental Medicine Research, Department of Genetics, İstanbul, Turkey)

Salih AKSU, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Yahya BÜYÜKAŞIK, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Nilgün SAYINALP, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Hakan GÖKER, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Osman İ. ÖZCEBE, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Uğur ÖZBEK, (İstanbul University, Institute for Experimental Medicine Research, Department of Genetics, İstanbul, Turkey)

İbrahim C. HAZNEDAROĞLU, (Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey)

Diğer Yazarlar

Turkish Journal of Hematology

11 1

Yıl: 2014 Cilt: 31 Sayı: 2 Sayfa Aralığı: 136 - 142 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi

Öz:

Amaç:Lokal renin-anjiotensin sisteminin (RAS) primitif hematopoezde önemli fonksiyonlara sahip olması, lokal otokrin kemik iliği (Kİ) RAS'ının da neoplastik hematopoezde aktif olabileceği hipotezini desteklemektedir. Bu çalışmanın amacı normal CD34+ hematopoetik kök hücreler ve multipl miyelom (MM) ilişkili progenitor hücrelerde kritik RAS elemanlarını araştırmaktır. Gereç ve Yöntemler:Çalışma grupları; hematolojik açıdan normal insanların toplam Kİ hücreleri (CBM) (n=10), allojeneik periferik kök hücre transplantasyonu için sağlıklı donörlerin CD34+ kök hücre örnekleri (CD34+CBM) (n=9), ve otolog periferik kök hücre transplantasyonu uygulanan MM hastalarının CD34+ kök hücre örnekleri (CD34+MM) (n=9) tarafından oluşturuldu. Bu örneklerde ana RAS elemanlarının gen ekspresyonları qRT-PCR yöntemiyle araştırıldı. Bulgular: CBM grubunun RENIN, anjiotensinojen (ANGTS), ve anjiotensin dönüştürücü enzim-I (ACE I) mRNA ekspresyon düzeyleri miyelom hastalarından anlamlı olarak yüksek idi (sırasıyla, p=0,03, p=0,002, ve p=0,0008). Sağlıklı allojeneik donörlerin CD34+ kök hücre örneklerindeki RENIN ve ANGTS mRNA ekspresyon düzeyleri myelom hastalarının kök hücre örneklerinden anlamlı derecede yüksek bulundu (p=0,001 and p=0,01). Bununla birlikte, CD34+CBM ve CD34+MM hematopoetik hücrelerde ACE I ekspresyon düzeyleri arasında anlamlı fark gözlenmedi (p=0,89).Sonuç: Lokal RAS elemanları, CBM ve CD34+CBM hematopoetik hücrelerinden daha az olmak kaydıyla, CD34+MM hematopoetik hücrelerinden de eksprese edilmektedir. Bu nokta MM'nin immünobiyolojisine odaklanmada ve transplantasyon tedavi protokollerinin oluşturulması sırasında otolog hücrelerin hazırlanmasında akılda tutulmalıdır.

Anahtar Kelime:

Konular: Hücre ve Doku Mühendisliği Hematoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji Genetik ve Kalıtım Hücre Biyolojisi

Local Renin-Angiotensin System in Normal Hematopoietic and Multiple Myeloma-Related Progenitor Cells

Öz:

Objective: The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM)-related progenitor cells.Materials and Methods:The study group comprised the total bone marrow cells (CBM) of 10 hematologically normal people, the CD34+ stem cell samples (CD34+CBM) of 9 healthy donors for allogeneic peripheral stem cell transplantation, and the CD34+ stem cell samples (CD34+MM) of 9 MM patients undergoing autologous peripheral stem cell transplantation. We searched for the gene expression of the major RAS components in healthy hematopoietic cells and myeloma cells by quantitative real-time polymerase chain reaction analysis.Results:RENIN, angiotensinogen (ANGTS), and angiotensin converting enzyme-I (ACE I) mRNA expression levels of CBM were significantly higher than those in myeloma patients (p=0.03, p=0.002, and p=0.0008, respectively). Moreover, RENIN and ANGTS mRNA expression levels were significantly higher in CD34+ stem cell samples of healthy allogeneic donors compared to those in myeloma patients (p=0.001 and p=0.01). However, ACE I expression levels were similar in CD34+CBM and CD34+MM hematopoietic cells (p=0.89).Conclusion:Although found to be lower than in the CBM and CD34+CBM hematopoietic cells, the local RAS components were also expressed in CD34+MM hematopoietic cells. This point should be kept in mind while focusing on the immunobiology of MM and the processing of autologous cells during the formation of transplantation treatment protocols.

Anahtar Kelime:

Konular: Hücre ve Doku Mühendisliği Hematoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji Genetik ve Kalıtım Hücre Biyolojisi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Haznedaroğlu IC, Tuncer S, Gürsoy M. A local renin -angiotensin system in the bone marrow. Med Hypotheses 1996;46:507-510.
2. Haznedaroglu IC. A local renin-angiotensin system in the bone marrow still awaits its Christopher Columbus. Exp Hematol 1998;26:279.
3. Haznedaroglu IC, Beyazit Y. Local bone marrow renin- angiotensin system in primitive, definitive and neoplastic haematopoiesis. Clin Sci (Lond) 2013;124:307-323.
4. Haznedaroglu IC, Beyazit Y. Pathobiological aspects of the local bone marrow renin-angiotensin system: a review. J Renin Angiotensin Aldosterone Syst 2010;11:205-213.
5. Haznedaroglu IC, Öztürk MA. Towards the understanding of the local hematopoietic bone marrow renin-angiotensin system. Int J Biochem Cell Biol 2003;35:867-880.
6. Strawn WB, Richmond RS, Tallant EA, Gallagher PE, Ferrario CM. Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells. Br J Haematol 2004;126:120-126.
7. Huang YL, Kuang J, Hu YZ, Song YB, Qiu RF, Mai WY. Bone marrow stromal cell transplantation combined with angiotensin-converting enzyme inhibitor treatment in rat with acute myocardial infarction and the role of insulin-like growth factor-1. Cytotherapy 2012;14:563-569.
8. Haznedaroğlu IC, Arici M, Büyükaşik Y. A unifying hypothesis for the renin-angiotensin system and hematopoiesis: sticking the pieces together with the JAKSTAT pathway. Med Hypotheses 2000;54:80-83.
9. Kwiatkowski BA, Richard RE. Angiotensin II receptorassociated protein (AGTRAP) synergizes with Mpl signaling to promote survival and to increase proliferation rate of hematopoietic cells. ASH Annual Meeting Abstracts 2009;114:3606.
10. Öztürk MA, Güven GS, Haznedaroglu IC. How hematopoietic stem cells know and act in cardiac microenvironment for stem cell plasticity? Impact of local renin-angiotensin systems. Med Hypotheses 2004;63:866-874.
11. Vrsalovic MM, Pejsa V, Veic TS, Kolonic SO, Ajdukovic R, Haris V, Jaksic O, Kusec R. Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status. Cancer Biol Ther 2007;6:1434-1436.
12.Durik M, Seva Pessoa B, Roks AJ. The renin-angiotensin system, bone marrow and progenitor cells. Clin Sci (Lond) 2012;123:205-223.
13. Heringer-Walther S, Eckert K, Schumacher SM, Uharek L, Wulf-Goldenberg A, Gembardt F, Fichtner I, Schultheiss HP, Rodgers K, Walther T. Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo. Haematologica 2009;94:857-860.
14. Abali H, Haznedaroğlu IC, Goker H, Çelik I, Özatlı D, Koray Z, Çağlar M. Circulating and local bone marrow reninangiotensin system in leukemic hematopoiesis: preliminary evidences. Hematology 2002;7:75-82.
15. Aksu S, Beyazit Y, Haznedaroglu IC, Canpinar H, Kekilli M, Uner A, Sayinalp N, Büyükaşik Y, Goker H, Ozcebe OI. Over-expression of angiotensin-converting enzyme (CD 143) on leukemic blasts as a clue for the activated local bone marrow RAS in AML. Leuk Lymphoma 2006;47:891-896.
16. Aksu S, Beyazit Y, Haznedaroglu IC, Kekilli M, Canpinar H, Misirlioğlu M, Uner A, Tuncer S, Sayinalp N, Büyükaşik Y, Goker H, Ozcebe OI. Enhanced expression of the local haematopoietic bone marrow renin-angiotensin system in polycythemia rubra vera. J Int Med Res 2005;33:661-667.
17. Beyazit Y, Aksu S, Haznedaroglu IC, Kekilli M, Misirlioglu M, Tuncer S, Karakaya J, Koca E, Buyukasik Y, Sayinalp N, Goker H. Overexpression of the local bone marrow reninangiotensin system in acute myeloid leukemia. J Natl Med Assoc 2007;99:57-63.
18.Casares MTG, De la Iglesia S, Perera M, Lemes A, Campo C, Gonzalez San Miguel JD, Bosch JM, Suarez A, Guerra L, Rodriguez-Peréz JC, Molero T. Renin expression in hematological malignancies and its role in the regulation of hematopoiesis. Leuk Lymphoma 2002;43:2377-2381.
19.Inigo SDL, Casares MTG, Jorge CEL, Leiza SM, Santana GS, Bravo de Laguna SJ, San Miguel JD, Caballero A, Alvarez Mdel M, Castellano AL, Henríquez HL, Labarta TM. Relevance of renin expression by real-time PCR in acute myeloid leukemia. Leuk Lymphoma 2006;47:409- 416.
20.Khodunova EE, Parovichnikova EN, Gal'tseva IV, Kulikov SM, Isaev VG, Savchenko VG. Dynamic study of Bcl-2, Bax, p53, and ACE expression in CD34+ cells of peripheral blood and bone marrow in acute leukemia patients in the course of induction chemotherapy. Ter Arkh 2011;83:32-37.
21.Wulf GG, Jahns-Streubel G, Nobiling R, Strutz F, Hemmerlein B, Hiddemann W, Wörmann B. Renin in acute myeloid leukaemia blasts. Br J Haematol 1998;100:335-337.
22.Koca E, Haznedaroglu IC, Acar K, Beyazit Y, Aksu S, Misirlioglu M, Tuncer S, Sayinalp N, Ozcebe OI, Uner A. Renin-angiotensin system expression in the K562 human erythroleukaemic cell line. J Renin Angiotensin Aldosterone Syst 2007;8:145-147.
23.Jokubaitis VJ, Sinka L, Driessen R, Whitty G, Haylock DN, Bertoncello I, Smith I, Péault B, Tavian M, Simmons PJ. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Blood 2008;111:4055-4063.
24. Sinka L, Biasch K, Khazaal I, Peault B, Tavian M. Angiotensinconverting enzyme (CD143) specifies emerging lymphohematopoietic progenitors in the human embryo. Blood 2012;119:3712-3723.
25. Tavian M, Biasch K, Sinka L, Vallet J, Peault B. Embryonic origin of human hematopoiesis. Int J Dev Biol 2010;54:1061- 1065.
26. Zambidis ET, Soon Park T, Yu W, Tam A, Levine M, Yuan X, Pryzhkova M, Péault B. Expression of angiotensinconverting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells. Blood 2008;112:3601-3614.
27.International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749- 757.
28.Uz B, Catal Tatonyan S, Sayitoglu M, Erbilgin Y, Hatirnaz Ng O, Buyukasik Y, Sayinalp N, Aksu S, Goker H, Ozcebe OI, Ozbek U, Haznedaroglu IC. Local hematopoietic renin-angiotensin system in myeloid versus lymphoid hematological neoplastic disorders. J Renin Angiotensin Aldosterone Syst 2013;14:308-314.
29. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
30.Comte L, Lorgeot V, Bignon J, Volkov L, Dupuis F, Wdzieczak-Bakala J, Praloran V. In vivo modifications of AcSDKP metabolism and haematopoiesis in mice treated with 5-fluorouracil and Goralatide. Eur J Clin Invest 1998;28:856-863.
31.Comte L, Lorgeot V, Volkov L, Allegraud A, Aldigier JC, Praloran V. Effects of the angiotensin-converting enzyme inhibitor enalapril on blood haematopoietic progenitors and acetyl-N-Ser-Asp-Lys-Pro concentrations. Eur J Clin Invest 1997;27:788-790.
32. Li J, Volkov L, Comte L, Herve P, Praloran V, Charbord P. Production and consumption of the tetrapeptide AcSDKP, a negative regulator of hematopoietic stem cells, by hematopoietic microenvironmental cells. Exp Hematol 1997;25:140-146.
33. Oliveira CR, Paredes-Gamero EJ, Barbosa CM, Nascimento FD, Batista EC, Reis FC, Martins AH, Ferreira AT, Carmona AK, Pesquero JB, Tersariol IL, Araújo RC, Bincoletto C. Myelopoiesis modulation by ACE hyperfunction in kinin B1 receptor knockout mice: relationship with AcSDKP levels. Chem Biol Interact 2010;184:388-395.
34. Abali H, Güllü IH, Engin H, Haznedaroğlu IC, Erman M, Tekuzman G. Old antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Med Hypotheses 2002;59:344-348.
35. Lin C, Datta V, Okwan-Duodu D, Chen X, Fuchs S, Alsabeh R, Billet S, Bernstein KE, Shen XZ. Angiotensin-converting enzyme is required for normal myelopoiesis. FASEB J 2010;25:1145-1155.
36. Marusic-Vrsalovic M, Dominis M, Jaksic B, Kusec R. Angiotensin I-converting enzyme is expressed by erythropoietic cells of normal and myeloproliferative bone marrow. Br J Haematol 2003;123:539-541.
37. Hubert C, Savary K, Gasc JM, Corvol P. The hematopoietic system: a new niche for the renin-angiotensin system. Nat Clin Pract Cardiovasc Med 2006;3:80-85.
38.Kato H, Ishida J, Imagawa S, Saito T, Suzuki N, Matsuoka T, Sugaya T, Tanimoto K, Yokoo T, Ohneda O, Sugiyama F, Yagami K, Fujita T, Yamamoto M, Nangaku M, Fukamizu A. Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor. FASEB J 2005;19:2023-2025.
39. Hara M, Ono K, Wada H, Sasayama S, Matsumori A. Preformed angiotensin II is present in human mast cells. Cardiovasc Drugs Ther 2004;18:415-420.
40. Park TS, Zambidis ET. A role for the renin-angiotensin system in hematopoiesis. Haematologica 2009;94:745-747.
41. Shen XZ, Bernstein KE. The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis. Cell Cycle 2011;10:1363-1369.
42. Stegbauer J, Lee DH, Seubert S, Ellrichmann G, Manzel A, Kvakan H, Muller DN, Gaupp S, Rump LC, Gold R, Linker RA. Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proc Natl Acad Sci U S A 2009;106:14942-14947.
43. Albayrak M, Celebi H, Albayrak A, Sayilir A, Yesil Y, Balcik OS, Yokus O, Celik T. Elevated serum angiotensin converting enzyme levels as a reflection of bone marrow renin-angiotensin system activation in multiple myeloma. J Renin Angiotensin Aldosterone Syst 2012;13:259-264.
44. Saka B, Dogan O, Tascioglu C, Besisik SK, Karan MA, Sayitoglu S, Erten N, Genc S. Bone marrow renin-angiotensin system in multiple myeloma. Clin Lymphoma Myeloma Leuk 2009;9:S10.
45. Tavian M, Peault B. The changing cellular environments of hematopoiesis in human development in utero. Exp Hematol 2005;33:1062-1069.
46. Peters A, Burridge PW, Pryzhkova MV, Levine MA, Park TS, Roxbury C, Yuan X, Péault B, Zambidis ET. Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol 2010;54:965-990.
47. Ager EI, Neo J, Christophi C. The renin-angiotensin system and malignancy. Carcinogenesis 2008;29:1675-1684.
48.George AJ, Thomas WG, Hannan RD. The renin-angiotensin system and cancer: old dog, new tricks. Nat Rev Cancer 2010;10:745-759.

APA	UZ B, ÇATAL TATONYAN S, Aydın Sayitoglu M, ERBILGIN Y, HATIRNAZ NG Ö, AKSU S, BÜYÜKAŞIK Y, Sayınalp N, GOKER A, ÖZCEBE O, Ozbek U, HAZNEDAROĞLU İ (2014). Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. , 136 - 142.
Chicago	UZ Burak,ÇATAL TATONYAN Suzin,Aydın Sayitoglu Muge,ERBILGIN YÜCEL,HATIRNAZ NG ÖZDEN,AKSU SALIH,BÜYÜKAŞIK Yahya,Sayınalp Nilgün,GOKER ALI HAKAN,ÖZCEBE Osman İ.,Ozbek Ugur,HAZNEDAROĞLU İbrahim C. Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. (2014): 136 - 142.
MLA	UZ Burak,ÇATAL TATONYAN Suzin,Aydın Sayitoglu Muge,ERBILGIN YÜCEL,HATIRNAZ NG ÖZDEN,AKSU SALIH,BÜYÜKAŞIK Yahya,Sayınalp Nilgün,GOKER ALI HAKAN,ÖZCEBE Osman İ.,Ozbek Ugur,HAZNEDAROĞLU İbrahim C. Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. , 2014, ss.136 - 142.
AMA	UZ B,ÇATAL TATONYAN S,Aydın Sayitoglu M,ERBILGIN Y,HATIRNAZ NG Ö,AKSU S,BÜYÜKAŞIK Y,Sayınalp N,GOKER A,ÖZCEBE O,Ozbek U,HAZNEDAROĞLU İ Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. . 2014; 136 - 142.
Vancouver	UZ B,ÇATAL TATONYAN S,Aydın Sayitoglu M,ERBILGIN Y,HATIRNAZ NG Ö,AKSU S,BÜYÜKAŞIK Y,Sayınalp N,GOKER A,ÖZCEBE O,Ozbek U,HAZNEDAROĞLU İ Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. . 2014; 136 - 142.
IEEE	UZ B,ÇATAL TATONYAN S,Aydın Sayitoglu M,ERBILGIN Y,HATIRNAZ NG Ö,AKSU S,BÜYÜKAŞIK Y,Sayınalp N,GOKER A,ÖZCEBE O,Ozbek U,HAZNEDAROĞLU İ "Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi." , ss.136 - 142, 2014.
ISNAD	UZ, Burak vd. "Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi". (2014), 136-142.

APA	UZ B, ÇATAL TATONYAN S, Aydın Sayitoglu M, ERBILGIN Y, HATIRNAZ NG Ö, AKSU S, BÜYÜKAŞIK Y, Sayınalp N, GOKER A, ÖZCEBE O, Ozbek U, HAZNEDAROĞLU İ (2014). Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. Turkish Journal of Hematology, 31(2), 136 - 142.
Chicago	UZ Burak,ÇATAL TATONYAN Suzin,Aydın Sayitoglu Muge,ERBILGIN YÜCEL,HATIRNAZ NG ÖZDEN,AKSU SALIH,BÜYÜKAŞIK Yahya,Sayınalp Nilgün,GOKER ALI HAKAN,ÖZCEBE Osman İ.,Ozbek Ugur,HAZNEDAROĞLU İbrahim C. Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. Turkish Journal of Hematology 31, no.2 (2014): 136 - 142.
MLA	UZ Burak,ÇATAL TATONYAN Suzin,Aydın Sayitoglu Muge,ERBILGIN YÜCEL,HATIRNAZ NG ÖZDEN,AKSU SALIH,BÜYÜKAŞIK Yahya,Sayınalp Nilgün,GOKER ALI HAKAN,ÖZCEBE Osman İ.,Ozbek Ugur,HAZNEDAROĞLU İbrahim C. Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. Turkish Journal of Hematology, vol.31, no.2, 2014, ss.136 - 142.
AMA	UZ B,ÇATAL TATONYAN S,Aydın Sayitoglu M,ERBILGIN Y,HATIRNAZ NG Ö,AKSU S,BÜYÜKAŞIK Y,Sayınalp N,GOKER A,ÖZCEBE O,Ozbek U,HAZNEDAROĞLU İ Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. Turkish Journal of Hematology. 2014; 31(2): 136 - 142.
Vancouver	UZ B,ÇATAL TATONYAN S,Aydın Sayitoglu M,ERBILGIN Y,HATIRNAZ NG Ö,AKSU S,BÜYÜKAŞIK Y,Sayınalp N,GOKER A,ÖZCEBE O,Ozbek U,HAZNEDAROĞLU İ Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi. Turkish Journal of Hematology. 2014; 31(2): 136 - 142.
IEEE	UZ B,ÇATAL TATONYAN S,Aydın Sayitoglu M,ERBILGIN Y,HATIRNAZ NG Ö,AKSU S,BÜYÜKAŞIK Y,Sayınalp N,GOKER A,ÖZCEBE O,Ozbek U,HAZNEDAROĞLU İ "Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi." Turkish Journal of Hematology, 31, ss.136 - 142, 2014.
ISNAD	UZ, Burak vd. "Normal Hematopoetik ve Multipl Myelom İlişkili Progenitor Hücrelerde Lokal Renin-Anjiotensin Sistemi". Turkish Journal of Hematology 31/2 (2014), 136-142.