Diş Hekimliğinde Akılcı Antibiyotik Kullanımı

AYDIN, MEHTAP; KILBOZ, M. Murat; Akici, Ahmet; KOYUNCUOĞLU, Cenker

Diş Hekimliğinde Akılcı Antibiyotik Kullanımı

Ahmet AKICI, (Tıbbi Farmakoloji AD, Marmara Üniversitesi Tıp Fakültesi, İstanbul)

M. Murat KILBOZ, (Tıbbi Farmakoloji AD, Marmara Üniversitesi Tıp Fakültesi, İstanbul)

Cenker KOYUNCUOĞLU, (Periodontoloji AD, İstanbul Aydın Üniversitesi Diş Hekimliği Fakültesi,)

Mehtap AYDIN (Em'eksiyon Hastalıkları ve Klinik Mikrobiyoloji AD, Başkent Üniversitesi İstanbul Sağlık Uygulama ve Araştırma Merkezi,)

Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi

74 16

Yıl: 2017 Cilt: 23 Sayı: 1 Sayfa Aralığı: 33 - 47 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Diş Hekimliğinde Akılcı Antibiyotik Kullanımı

Öz:

Başka pek çok ülkede olduu gibi, Türkiye'de de antibiyotiklerin gereksiz ya da yanlış kulla-- nımları ve buna bağlı akılcı olmayan antibiyotik kullanımı sorunu yaygındır. Antibiyotikler diş he-- kimlerinin reçete ettiği ilaçlar arasında da önemli yer tutmaktadır. Antibiyotiklerin akılcı olmayan kullanımıyla ortaya çıkan sorunlar güncel tartışma konuları arasında yer almakta ve ilgili çevre-- lerce çözüm önerileri üzerinde durulmaktadır. Dental enfeksiyonların tedavi ve profilaksisinin akılcı ilaç kullanımı (AİK) genel ilkelerine uyularak düzenlenmesi yol göstericidir. AİK, "ilaçların hastaların klinik ihtiyaçlarına uygun şekilde, uygun dozlarda, yeterli sürede, kendilerine ve top-- luma en düşük maliyette almaları" olarak tanımlanmaktadır. Bu çerçeve içerisinde antibiyotikle-- rin akılcı kullanımında diş hekimlerine önemli görevler düşmektedir. Diş hekimi, öncelikle bu ilaçlar konusunda yeterli farmakoloji bilgisine sahip olmalı, antibiyotikleri gelişigüzel biçimde uy-- gunsuz kullanmamaya özen göstermeli, antibiyotik seçimini "kişisel tedavi" ve "kişisel ilaç" yak-- laşımıyla her bir endikasyonda belirlemeli, reçetelemeyi planladığı antibiyotiğin hastaya uygunluğunu değerlendirmeli, ilaç dışındaki diğer tedavi işlemlerini ve tavsiyelerini eksiksiz yap-- malı, doğru format ve içerikte reçete yazmalı, hastayı yeterince bilgilendirmeli, süreci takip ede-- rek başarıyla yönetmeli ve hastayı tedavinin ortak katılımcısı yapmalıdır. Hastaya veya dental işlemlere bağlı özel durumlar söz konusu olduğunda, diş hekimlerinin AİK penceresinden bu ko-- nuların her birine özgü yeterli bilgi ve beceriye önceden sahip olması ve bunun için hazırlıklı ol-- ması gerekmektedir.

Anahtar Kelime:

Konular: Diş Hekimliği

The Rational Use of Antibiotics in Dentistry: Review

Öz:

Irrational use of antibiotics associated with unnecessary or improper usage, is also a common problem in Turkey as reported in many countries. Antibiotics, take an important place among dentist prescriptions. The problem of irrational use of antibiotics is situated between the cur-rent debate and related authorities focused on solutions. Following the general principles of rational use of medicine (RUM) is guide to treatment and prophylaxis of dental infections. RUM is defined as "patients receive medications appropriate to their clinical needs, in doses that meet their own individual requirements, for an adequate period of time, and at the lowest cost to them and their community". In this viewpoint’ the dentist has an important role for the rational use of an- tibiotics. Primarily the dentist should have sufficient knowledge of pharmacology about these med- ications and take care not to use antibiotics inattentively and inappropriately. The choice of antibiotic for every indication should be based on “personal treatment’’, “personal medication’’ ap- proaches. The dentist intends to prescribe antibiotics should assess the suitability of patients. All other treatment procedures and recommendations out of the drug should be made completely. The prescription should be written at correct format and content. The patient should be informed about the antibiotic treatment sufficiently. The dentist must successfully managed the process and make the patient common participants of the treatment. Due to special conditions in the case of the pa- tient or dental procedures, the dentist must have sufficient knowledge and skills about each issue of RUM previously

Anahtar Kelime:

Konular: Diş Hekimliği

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. World Health Organization. The rational use of drugs. Report of Conference of Ex-perts. Nairobi, 1985. Geneva: World Health Organization; 1987. p.321.
2. Akıcı A. [Basic principles of rational drug use and antibiotics]. Antibiyotikler ve Klinik Kullanımları Dergisi 2012;1:1-13.
3. Niederman MS. Principles of appropriate antibiotic use. Int J Antimicrob Agents 2005;26 Suppl 3:S170-5.
4. World Health Organization (WHO). WHO global strategy for containment of anti-microbial resistance. Rev Panam Salud Publica 2001;10(4):284-94.
5. Goossens H. Antibiotic consumption and link to resistance. Clin Microbiol Infect 2009;15 Suppl 3:12-5.
6. Löffler C, Böhmer F, Hornung A, Lang H, Burmeister U, Podbielski A, et al. Dental care resistance prevention and antibiotic prescribing modification-the cluster-randomised controlled DREAM trial. Implement Sci 2014;9:27.
7. Versporten A, Bolokhovets G, Ghazaryan L, Abilova V, Pyshnik G, Spasojevic T, et al. Antibiotic use in eastern Europe: a cross-national database study in coordination with the WHO Regional Office for Europe. Lancet Infect Dis 2014;14(5):381-7.
8. Karabay O, Hosoglu S. Increased antimicrobial consumption following reimburse-ment reform in Turkey. J Antimicrob Chemother 2008;61(5):1169-71.
9. Kandemir S, Ergül N. Grievances in cases using antibiotics due to orodental problems and assessmentof the need for antibiotics. Int Dent J 2000;50(2):73-7.
10. Bahrani-Mougeot FK, Paster BJ, Coleman S, Ashar J, Barbuto S, Lockhart PB. Di-verse and novel oral bacterial species in blood following dental procedures. J Clin Microbiol 2008; 46(6):2129-32.
11. Chow AW. Infections of the oral cavity, neck, and head. In: Bennet JE, Dolin R, Blaser MJ eds. Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier, Saunders; 2015. p.789-805.
12. Matthews DC, Tabesh M. Detection of localized tooth-related factors that predis-pose to periodontal infections. Periodontol 2000. 2004;34:136-50.
13. Longman LP, Preston AJ, Martin MV, Wilson NH. Endodontics in the adult pa-tient: the role of antibiotics. J Dent 2000;28(8):539-48.
14. Anderson R, Calder L, Thomas DW. Antibiotic prescribing for dental conditions: general medical practitioners and dentists compared. Br Dent J 2000;188(7):398-400.
15. Ulusoy S. [General principles on the use of antimicrobial drugs]. Willke Topçu A, Söyletir G, Doğanay M, editörler. Enfeksiyon Hastalıkları ve Mikrobiyolojisi. 3. Baskı. İstanbul: Nobel Tıp Kitabevleri; 2008. p.219-27.
16. Lawler B, Sambrook PJ, Goss AN. Antibiotic prophylaxis for dentoalveolar surgery: is it indicated? Aust Dent J 2005;50(4 Suppl 2):S54-9.
17. Bayındır Y. [Judicious antibiotic usage in dental infections]. İnönüÜniv Tıp Fak Derg 2003; 10(4):213-6.
18. De Vries TPGM, Henning RH, Hogerzeil HV, Fresle DA. Guide to Good Prescrib-ing. World Health Organization Action Programme on Essential Drugs. Geneva: World Health Organization ; 1994. p.1-95.
19. Akıcı A, Uzuner A. [Rational use of medicines]. Akıcı A, editör. Birinci Basamak Sağlık Kurumlarında Çalışan Hekimlere Yönelik Akılcı İlaç Kullanımı. T.C. Sosyal güvenlik kurumu başkanlığı SGK yayın No: 112. 1. Baskı İstanbul: Kayhan Matbaacılık San. ve Tic Ltd. Şti. 2013.
20. Akıcı A. [Rational use of medicines]. Akılcı İlaç Kullanımı. T.C. Sağlık Bakanlığı Sağlık Araştırmaları Genel Müdürlüğü Yayını. 1. baskı. Ankara; 2013. p.8-141.
21. Ellison SJ. The role of phenoxymethyl penicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review. Br Dent J 2009;206(7):357-62.
22. Kuriyama T, Karasawa T, Nakagawa K, Saiki Y, Yamamoto E, Nakamura S. Bac-teriologic features and antimicrobial susceptibility in isolates from orofacial odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90(5):600-8.
23. Eliopoulos GM, Moellering RC. Principles of anti-infective therapy. In: Bennet JE, Dolin R, Blaser MJ eds. Principles and Practice of Infectious Diseases. 8th ed. Phila-delphia: Elsevier, Sounders; 2015. p.224-34.
24. Baumgartner JC. Antibiotics and treatment of endodontic infections. American Associations of Endodontics, Colleagues for Excellence Newsletters. 2006;2:1-6.
25. Morrow SG. Use and abuse of antibiotics. American Association of Endodontics, Colleagues for Excellence Newsletter 2012;4:1-8.
26. Gilbert DN, Moellering RC, Eliopoulos GM, Chambers HF, Saag MS. Dosages of antimicrobial drugs in adult patients with renal impairment. In: Gilbert DN, Moellering RC, Eliopoulos GM, Chambers HF, Saag MS, eds. The Sandford Guide to Antimicrobial Therapy. 43rd ed. USA: Antimicrobial Therapy, Inc;2013. p.204-13.
27. Chambers HF, Petri WA. Section: VIII: Chemotherapy of microbial diseases. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman & Gilman’s the Pharmacological Basis of Therapeutics. 10thed. United States: Mc Graw Hill Companies; 2001. p.1141-271.
28. Kayaalp O. [Drugs used in the treatment of infections]. Türkiye İlaçla Tedavi Kılavuzu 2011- 2012 Formüleri (TİK-6). Ankara: Pelikan Yayıncılık; 2011.p.350-411.
29. Bush K. β-Lactam antibiotics: penicillins. In: Finch RG, Greenwood D, Ragnar Norrby S, Whitley RJ, eds. Antibiotic and Chemotherapy. 9thed. Edinburgh; New York: Saunders Elsevier; 2010. p.200-25.
30. Schleiss MR. Principles of antibacterial therapy. Part XVI: Infectious diseases, Section 3; Antibiotic therapy, Chapter: 179. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbok of Pediatrics. 18thed. Philadelphia: Saunders; 2007. p.1113-8.
31. Greenwood D. β-lactam antibiotics: cephalosporins. In: Finch RG, Greenwood D, RagnarNorrby S, Whitley RJ, eds. Antibiotic and Chemotherapy. 9thed. Edinburgh; New York: Saunders Elsevier; 2010. p.170-99.
32. Honibald EN, Mathew S, Padmanaban J, Sundaram E, Ramamoorthy RD. Perioceutics: matrix metalloproteinase inhibitors as an adjunctive therapy for inflammatory periodontal disease. J Pharm Bioallied Sci 2012;4(Suppl 2):S417-21.
33. Baltacıoğlu E, Akalın A. [Tetracyclines and their non-antimicrobial properties. A new approach to their use in periodontal treatment]. Hacettepe Dişhekimliği Fakültesi Dergisi 2006;30(1):97-107.
34. Akca G, Kayaoğlu G, Akca AE, Sultan N. [Viridans streptococci isolated from dentin caries and their susceptibilities to common and new generation antibiotics]. GÜ Diş Hek Fak Derg 2010;27(3):187-93.
35. Ayaz C. [Antibiotic combinations]. Klimik Derg 2001;14(3):140-3.
36. Termine N, Panzarella V, Ciavarella D, Lo Muzio L, D’Angelo M, Sardella A, et al. Antibiotic prophylaxis in dentistry and oral surgery: use and misuse. Int Dent J 2009;59(5):263- 70.
37. Bahrani-Mougeot FK, Paster BJ, Coleman S, Ashar J, Barbuto S, Lockhart PB. Diverse and novel oral bacterial species in blood following dental procedures. J Clin Microbiol 2008; 46(6):2129-32.
38. Seymour RA, Lowry R, Whitworth JM, Martin MV. Infective endocarditis, dentis-try and antibiotic prophylaxis; time for a rethink? Br Dent J 2000;189(11):610-6
39. Lodi G, Figini L, Sardella A, Carrassi A, Del Fabbro M, Furness S. Antibiotics to prevent complications following tooth extractions. Cochrane Database Syst Rev 2012;11: CD003811.
40. Durack DT. Prophylaxis of infective endocarditis. In, Bennet JE, Dolin R, Blaser MJ, eds. Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier, Sounders; 2015. p.1057-65.
41. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthe-sia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2007;116(15): 1736-54.
42. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, et al. AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;63(22): e57-185.
43. Allen U. Infective endocarditis: Update Guidelines. Paediatr Child Healt 2010;15(4):205-8.
44. American Dental Association; American Academy of Orthopedic Surgeons. Anti-biotic prophylaxis for dental patients with total joint replacements. J Am Dent Assoc 2003;134(7): 895-9.
45. Little JW, Jacobson JJ, Lockhart PB; American Academy of Oral Medicine. The dental treatment of patients with joint replacements: a position paper from the Ameri-can Academy of Oral Medicine. J Am Dent Assoc 2010;141(6);667-71.
46. Crossley KB, Peterson PK. Infections in the elderly. In; Bennet JE, Dolin R, Blaser MJ, eds. Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier, Sounders; 2015. p.3459-65.
47. Nazlıel HÇ. [Oral and dental health in elderly]. Geriatri 1999;2(1):14-21.
48. Akıcı A. [Prescribing in elderly according to the principles of rational drug use and the dimentions of drug utilization in elderly in Turkey]. Turkish Journal of Geriatrics 2006;(Suppl):19- 27.
49. Gelal A. [Rational drug use in elderly]. Turkiye Klinikleri J Pharmacol-Special Topics 2015; 3(1):57-64.
50. Chen Y, Zhu LL, Zhou Q. Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interven-tions on fall risk in elderly patients. Ther Clin Risk Manag 2014; 10:437-48.
51. Sotaniemi EA, Arranto AJ, Pelkonen O, Pasanen M. Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther 1997;61(3):331-9.
52. Cohen E, Nardi Y, Krause I, Goldberg E, Milo G, Garty M, et al. A longitudinal assessment of the natural rate of decline in renal function with age. J Nephrol 2014;27:635-41.
53. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER) Pregnancy, Lactation, and Reproductive Potential: Labeling for Human Prescription Drug and Biological ProductsContent and Format Guidance for Industry 2015;1:1-20.
54. Lee A, Grant E, Golightly P. Chapter one and two. Principle of drug use in preg-nancy. Princible of prescribing in lactation. In: Lee A, Inch S, Finnigan D, eds. Thera-peutics in Pregnancy and Lactation. Abingdon; USA: Radcliffe Medical Press Ltd; 2000. p.1-22.
55. Akal N. [Antibiotics in pediatric dentistry]. GÜ Diş Hek Fak Derg 1998;15(1-2-3):163-72.
56. American Academy of Pediatric Dentistry. Guideline on Use of Antibiotic Therapy for Pediatric Dental Patients. AAPD 2014;6:289-91.
57. Dodson TB, Perrott DH, Kaban LB. Pediatric maxillofacial infections: a retro-spective study of 113 patients. J Oral Maxillofac Surg 1989;47(4):327-30.
58. Keenan JV, Farman AG, Fedorowicz Z, Newton JT. A Cochrane system review finds no evidence to support the use of antibiotics for pain relief in irreversible pulpitis. J Endod 2006;32(2):87-92.
59. Andersson L, Andreasen JO, Day P, Heithersay G, Trope M, Diangelis AJ, et al; International Association of Dental Traumatology. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol 2012;28(2):88-96.
60. Akıcı N, Başaran NF. [Rational use of medicine in children]. Turkiye Klinikleri J Pharmacol-Special Topics 2015;3(1):50-6.
61. Canoğlu E, Güngör CH, Bozkurt A. [Medicine usage in pediatric dentistry]. Hacettepe Diş Hekimliği Fakültesi Dergisi 2009;33(2):30-44.
62. Baumgartner JC, Siqueira JF Jr, Sedgley CM, Kishen A. Microbiology of endo-dontic disease, In: Ingle JI, Bakland LK, Baumgartner JC, eds. Ingle’s Endodontics. 6thed. Hamilton, Canada: BC Decker Inc; 2008. p.221-308.
63. Bal F. [Prophylactic and therapeutic use of antibiotics in dentistry: the proper use of antibiotics in dentistry]. Hastane İnfeksiyonları Dergisi 2006;10(1):30-6.
64. Baumgartner JC, Xia T. Antibiotic susceptibility of bacteria associated with en-dodontic abscesses. J Endodon 2003;29(1):44-7.
65. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol 1979;50(10):495-509.
66. Feres M, Figueiredo LC, Soares GM, Faveri M. Systemic antibiotics in the treatment of periodontitis. Periodontol 2000 2015;67(1):131- 86.
67. Slots J; Research, Science and Therapy Committee. Systemic antibiotics in periodontics. J Periodontol 2004;75(11):1553-65.
68. Kapoor A, Malhotra R, Grover V, Grover D. Systemic antibiotic therapy in periodontics. Dental Res J (Isfahan) 2012;9(5):505-15.
69. Dahlén G. Microbiology and treatment of dental abscesses and periodontal-endodontic lesions. Periodontol 2000 2002;28:206-39.
70. Cortellini P, Bowers G. Periodontal regeneration of intrabony defects: an evidence-based treatment approach. Int J Periodontics Restorative Dent 1995;15(2):129-45.
71. Slots J, MacDonald ES, Nowzari H. Infectious aspects of periodontal regeneration. Periodontol 2000 1999;19:164-72.
72. Minabe M, Kodama T, Kogou T, Fushimi H, Sugiyama T, Takeuchi K, et al. Clinical significance of antibiotic therapy in guided tissue regeneration with a resorbable membrane. Periodontal Clin Investig 2001;23(1):20-30.
73. Powell CA, Mealey BL, Deas DE, McDonnell HT, Moritz AJ. Post-surgical infections: prevalence associated with various periodontal surgical procedures. J Periodontol 2005;76(3): 329-33.
74. Oswal S, Ravindra S, Sinha A, Manjunath S. Antibiotics in periodontal surgeries: A prospective randomised cross over clinical trial. J Indian Soc Periodontol 2014;18(5):570-4.

APA	Akici A, KILBOZ M, KOYUNCUOĞLU C, AYDIN M (2017). Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. , 33 - 47.
Chicago	Akici Ahmet,KILBOZ M. Murat,KOYUNCUOĞLU Cenker,AYDIN MEHTAP Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. (2017): 33 - 47.
MLA	Akici Ahmet,KILBOZ M. Murat,KOYUNCUOĞLU Cenker,AYDIN MEHTAP Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. , 2017, ss.33 - 47.
AMA	Akici A,KILBOZ M,KOYUNCUOĞLU C,AYDIN M Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. . 2017; 33 - 47.
Vancouver	Akici A,KILBOZ M,KOYUNCUOĞLU C,AYDIN M Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. . 2017; 33 - 47.
IEEE	Akici A,KILBOZ M,KOYUNCUOĞLU C,AYDIN M "Diş Hekimliğinde Akılcı Antibiyotik Kullanımı." , ss.33 - 47, 2017.
ISNAD	Akici, Ahmet vd. "Diş Hekimliğinde Akılcı Antibiyotik Kullanımı". (2017), 33-47.

APA	Akici A, KILBOZ M, KOYUNCUOĞLU C, AYDIN M (2017). Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi, 23(1), 33 - 47.
Chicago	Akici Ahmet,KILBOZ M. Murat,KOYUNCUOĞLU Cenker,AYDIN MEHTAP Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi 23, no.1 (2017): 33 - 47.
MLA	Akici Ahmet,KILBOZ M. Murat,KOYUNCUOĞLU Cenker,AYDIN MEHTAP Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi, vol.23, no.1, 2017, ss.33 - 47.
AMA	Akici A,KILBOZ M,KOYUNCUOĞLU C,AYDIN M Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi. 2017; 23(1): 33 - 47.
Vancouver	Akici A,KILBOZ M,KOYUNCUOĞLU C,AYDIN M Diş Hekimliğinde Akılcı Antibiyotik Kullanımı. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi. 2017; 23(1): 33 - 47.
IEEE	Akici A,KILBOZ M,KOYUNCUOĞLU C,AYDIN M "Diş Hekimliğinde Akılcı Antibiyotik Kullanımı." Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi, 23, ss.33 - 47, 2017.
ISNAD	Akici, Ahmet vd. "Diş Hekimliğinde Akılcı Antibiyotik Kullanımı". Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi 23/1 (2017), 33-47.