The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats
Yıl: 2018 Cilt: 24 Sayı: 4 Sayfa Aralığı: 491 - 496 Metin Dili: İngilizce DOI: 10.9775/kvfd.2018.19416 İndeks Tarihi: 05-12-2018
The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats
Öz: This study determined the efficacy of a combination of aglepristone and cabergoline on termination of mid-term cat pregnancies. Twenty cats withunwanted pregnancies between 30-40 days were included in the study. Aglepristone (10 mg/kg, sc) was given to the AGL group (n=6) twice in a24-h interval. Cabergoline (5 μg/kg, peros) was administered to the CBG group (n=7) once daily until abortion started or for 8 days. AGL+CBG (n=7)received a combined treatment with both drugs. Abortion occurred in 50% of cats in the AGL group, 71.4% in the CBG group, and 100% in theAGL+CBG. However, the completion of pregnancy termination rate was 85.7% because of fetal retention in one cat from the AGL+CBG group.The interval between treatment-start of abortion (T-SA) was shorter in the AGL+CBG group (3.6±0.3 days) than in the AGL (6.5±0.0) and CBG(6.2±0.2) groups (P<0.01). Similarly, the interval between treatment-end of abortion (T-EA) was shorter in the combined group (4.3±0.5 days) thanthe others (7.3±0.3 and 6.9±0.9 days, respectively) (P<0.01). Decreasing in progesterone concentration was non-significant in the AGL group fromthe start of treatment to abortion completion day (dA/d8), but significant in the others (P<0.001). On dA/d8, it was significantly lower in the CBGgroup (P<0.01) and combined group (P<0.01) than in the AGL group. Only slight diarrhea was observed in 15.4% of the AGL+CBG group. In conclusion,the AGL+CBG combination increased the rate of abortion induction and significantly shortened T-SA and T-EA with negligible side effects.
Anahtar Kelime: Konular:
Kedilerde Orta Dönem Gebeliklerin Sonlandırılmasında Aglepriston ve Cabergolinin Tek Başlarına veya Birlikte Uygulanmasının Etkinliği
Öz: Bu çalışmada kedilerde orta dönem gebeliklerin sonlandırılmasında aglepriston ve cabergolin kombinasyonunun etkinliği belirlendi. Çalışmada istenmeyen gebeliği olan ve gebeliğin 30-40. günleri arasında olan 20 kedi kullanıldı. AGL grubuna (n=6) aglepriston (10 mg/kg, sc) 24 saat arayla iki defa uygulandı. CBG grubuna (n=7) cabergolin (5 μg/kg, peros) abortuslar başlayana kadar veya 8 gün süreyle günlük olarak uygulandı. AGL+CBG (n=7) grubuna ise her iki ilaç birlikte verildi. AGL grubunda kedilerin %50’sinde, CBG grubunda %71.4’ünde ve AGL+CBG grubunda ise %100’ünde abortuslar şekillendi. Bununla birlikte AGL+CBG grubundaki bir kedide fetal retensiyondan dolayı gebelik sonlanma oranı %85.7 olarak şekillendi. Tedavi-abortus başlama aralığı (T-SA) AGL+CBG grubunda (3.6±0.3 gün) AGL (6.5±0.0) ve CBG (6.2±0.2) gruplarından daha kısa bulundu (P<0.01). Benzer şekilde, tedavi-abortus tamamlanma aralığı (T-EA) kombine grupta (4.3±0.5 gün) diğer gruplardan (sırasıyla, 7.3±0.3 ve 6.9±0.9 gün) daha kısa olarak belirlendi (P<0.01). Tedavi başlangıcından abortus tamamlanma gününe (dA/d8) arasında progesterone konsantrasyonundaki azalma AGL grubunda önemsizken CBG ve kombine grupta önemliydi (P<0.001). Progesteron düzeyi dA/d8 gününde CBG ve kombine grupta AGL’den önemli derecede düşüktü (P<0.01). AGL+CBG grubunda 15.4% oranında sadece hafif derecede ishal görüldü. Sonuç olarak, AGL+CBG kombinasyonun abortusları uyarma oranını artırdığı, T-SA ve T-EA’yı göz ardı edilebilecek düzeyde yan etki ile önemli oranda kısalttığı belirlendi.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | AY S, ÖNYAY F, Saral G, Kaya D, Aslan S, FINDIK M (2018). The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. , 491 - 496. 10.9775/kvfd.2018.19416 |
| Chicago | AY Serhan Serhat,ÖNYAY Firdevs,Saral Gülşah,Kaya Duygu,Aslan Selim,FINDIK Murat The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. (2018): 491 - 496. 10.9775/kvfd.2018.19416 |
| MLA | AY Serhan Serhat,ÖNYAY Firdevs,Saral Gülşah,Kaya Duygu,Aslan Selim,FINDIK Murat The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. , 2018, ss.491 - 496. 10.9775/kvfd.2018.19416 |
| AMA | AY S,ÖNYAY F,Saral G,Kaya D,Aslan S,FINDIK M The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. . 2018; 491 - 496. 10.9775/kvfd.2018.19416 |
| Vancouver | AY S,ÖNYAY F,Saral G,Kaya D,Aslan S,FINDIK M The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. . 2018; 491 - 496. 10.9775/kvfd.2018.19416 |
| IEEE | AY S,ÖNYAY F,Saral G,Kaya D,Aslan S,FINDIK M "The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats." , ss.491 - 496, 2018. 10.9775/kvfd.2018.19416 |
| ISNAD | AY, Serhan Serhat vd. "The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats". (2018), 491-496. https://doi.org/10.9775/kvfd.2018.19416 |
| APA | AY S, ÖNYAY F, Saral G, Kaya D, Aslan S, FINDIK M (2018). The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 24(4), 491 - 496. 10.9775/kvfd.2018.19416 |
| Chicago | AY Serhan Serhat,ÖNYAY Firdevs,Saral Gülşah,Kaya Duygu,Aslan Selim,FINDIK Murat The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 24, no.4 (2018): 491 - 496. 10.9775/kvfd.2018.19416 |
| MLA | AY Serhan Serhat,ÖNYAY Firdevs,Saral Gülşah,Kaya Duygu,Aslan Selim,FINDIK Murat The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.24, no.4, 2018, ss.491 - 496. 10.9775/kvfd.2018.19416 |
| AMA | AY S,ÖNYAY F,Saral G,Kaya D,Aslan S,FINDIK M The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2018; 24(4): 491 - 496. 10.9775/kvfd.2018.19416 |
| Vancouver | AY S,ÖNYAY F,Saral G,Kaya D,Aslan S,FINDIK M The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2018; 24(4): 491 - 496. 10.9775/kvfd.2018.19416 |
| IEEE | AY S,ÖNYAY F,Saral G,Kaya D,Aslan S,FINDIK M "The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 24, ss.491 - 496, 2018. 10.9775/kvfd.2018.19416 |
| ISNAD | AY, Serhan Serhat vd. "The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 24/4 (2018), 491-496. https://doi.org/10.9775/kvfd.2018.19416 |
