Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model
Yıl: 2018 Cilt: 28 Sayı: 4 Sayfa Aralığı: 654 - 662 Metin Dili: İngilizce DOI: 10.5137/1019-5149.JTN.20811-17.1 İndeks Tarihi: 28-06-2019
Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model
Öz: AIM: To investigate the effects of systemic application of bone marrow-derived mesenchymal stem cells in a compression modelof peripheral nerve injury.MATERIAL and METHODS: Twenty-four male Wistar albino rats were randomly divided into 3 equal groups (n=8): Control (C), injury(I), and stem cell and injury (SI). The sciatic nerve of the rats in the I and SI groups was subjected to clip compression for 5 minutes.Moreover, approximately 5x105 bone marrow-derived mesenchymal stem cells were given via tail vein of the rats in the SI groupimmediately after clip compression. The nerve conduction velocities and amplitudes of the rats were measured 30 days later. Then,the sciatic nerves were removed, and myelin damage grading and axon counting were performed. The data were analyzed by OneWay ANOVA and Tukey’s post-hoc test. P values less than 0.05 were considered to be statistically significant.RESULTS: While the proximal, distal and mean latency values were higher in the I and SI groups than in the control group, the samemeasurements were lower in the SI group than in the I group. While the nerve conduction velocity, the amplitude of compoundmuscle action potential and the number of axons were lower in the I and SI groups than in the control group, the same measurementswere higher in the SI group than in the I group. Moreover, myelin damage was found to be lower in the SI group than in the I group.CONCLUSION: Systemic application of bone marrow-derived mesenchymal stem cells in a compression model of peripheral nerveinjury has a positive impact on both myelin sheath and axon survival.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | kizilay z, AKTAŞ S, KAHRAMAN CETIN N, BAKAY ILHAN D, ERSOY G, ERKEN H (2018). Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. , 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| Chicago | kizilay zahir,AKTAŞ Serdar,KAHRAMAN CETIN Nesibe,BAKAY ILHAN Didem,ERSOY Gulfem,ERKEN Haydar Ali Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. (2018): 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| MLA | kizilay zahir,AKTAŞ Serdar,KAHRAMAN CETIN Nesibe,BAKAY ILHAN Didem,ERSOY Gulfem,ERKEN Haydar Ali Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. , 2018, ss.654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| AMA | kizilay z,AKTAŞ S,KAHRAMAN CETIN N,BAKAY ILHAN D,ERSOY G,ERKEN H Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. . 2018; 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| Vancouver | kizilay z,AKTAŞ S,KAHRAMAN CETIN N,BAKAY ILHAN D,ERSOY G,ERKEN H Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. . 2018; 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| IEEE | kizilay z,AKTAŞ S,KAHRAMAN CETIN N,BAKAY ILHAN D,ERSOY G,ERKEN H "Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model." , ss.654 - 662, 2018. 10.5137/1019-5149.JTN.20811-17.1 |
| ISNAD | kizilay, zahir vd. "Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model". (2018), 654-662. https://doi.org/10.5137/1019-5149.JTN.20811-17.1 |
| APA | kizilay z, AKTAŞ S, KAHRAMAN CETIN N, BAKAY ILHAN D, ERSOY G, ERKEN H (2018). Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. Turkish Neurosurgery, 28(4), 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| Chicago | kizilay zahir,AKTAŞ Serdar,KAHRAMAN CETIN Nesibe,BAKAY ILHAN Didem,ERSOY Gulfem,ERKEN Haydar Ali Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. Turkish Neurosurgery 28, no.4 (2018): 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| MLA | kizilay zahir,AKTAŞ Serdar,KAHRAMAN CETIN Nesibe,BAKAY ILHAN Didem,ERSOY Gulfem,ERKEN Haydar Ali Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. Turkish Neurosurgery, vol.28, no.4, 2018, ss.654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| AMA | kizilay z,AKTAŞ S,KAHRAMAN CETIN N,BAKAY ILHAN D,ERSOY G,ERKEN H Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. Turkish Neurosurgery. 2018; 28(4): 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| Vancouver | kizilay z,AKTAŞ S,KAHRAMAN CETIN N,BAKAY ILHAN D,ERSOY G,ERKEN H Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model. Turkish Neurosurgery. 2018; 28(4): 654 - 662. 10.5137/1019-5149.JTN.20811-17.1 |
| IEEE | kizilay z,AKTAŞ S,KAHRAMAN CETIN N,BAKAY ILHAN D,ERSOY G,ERKEN H "Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model." Turkish Neurosurgery, 28, ss.654 - 662, 2018. 10.5137/1019-5149.JTN.20811-17.1 |
| ISNAD | kizilay, zahir vd. "Effect of Systemic Application of Bone Marrow-Derived Mesenchymal Stem Cells on Healing of Peripheral Nerve Injury in an Experimental Sciatic Nerve Injury Model". Turkish Neurosurgery 28/4 (2018), 654-662. https://doi.org/10.5137/1019-5149.JTN.20811-17.1 |
