The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations
Yıl: 2017 Cilt: 47 Sayı: 2 Sayfa Aralığı: 45 - 51 Metin Dili: İngilizce DOI: 10.5152/IstanbulJPharm.2017.007 İndeks Tarihi: 21-10-2019
The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations
Öz: The objective of this study was to develop a chewing gum formulation for benzydamine hydrochloride (BN) and evaluate the effect of differentco-compression agents on physicochemical parameters and in vitro drug release profile. BN has been utilized in symptomatictreatment for pain and irritations of the mouth and throat. Chewing gum formulations of BN were produced using direct compressionmethod. In fabricated chewing gums, except pharmacopeia analysis, physical and structural analysis like thickness, weight variation,elasticity and compressibility were evaluated. The release of BN from the gum was studied using the chewing apparatus which havebeen designed for procuring the release of BN from the chewing gum.The quantity of BN present in the chewing gum and the releasemedium were quantified by spectrophotometric method. Gum formulations showed promising in vitro release profiles, in which 80–90% BN was released in a sustained manner over 20 min of chewing time. In addition, it was observed that the drug release was fittedinto matrix diffusion kinetic and revealed a non-Fickian drug release mechanism. This study suggests that BN in a gum formulation isa suitable dosage form for the delivery in the oral cavity, thereby and serving as an instant analgesic.
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| APA | AKBAL DAĞISTAN Ö, Cevher E, ARAMAN A (2017). The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. , 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| Chicago | AKBAL DAĞISTAN ÖZLEM,Cevher Erdal,ARAMAN AHMET OĞUL The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. (2017): 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| MLA | AKBAL DAĞISTAN ÖZLEM,Cevher Erdal,ARAMAN AHMET OĞUL The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. , 2017, ss.45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| AMA | AKBAL DAĞISTAN Ö,Cevher E,ARAMAN A The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. . 2017; 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| Vancouver | AKBAL DAĞISTAN Ö,Cevher E,ARAMAN A The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. . 2017; 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| IEEE | AKBAL DAĞISTAN Ö,Cevher E,ARAMAN A "The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations." , ss.45 - 51, 2017. 10.5152/IstanbulJPharm.2017.007 |
| ISNAD | AKBAL DAĞISTAN, ÖZLEM vd. "The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations". (2017), 45-51. https://doi.org/10.5152/IstanbulJPharm.2017.007 |
| APA | AKBAL DAĞISTAN Ö, Cevher E, ARAMAN A (2017). The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. Istanbul Journal of Pharmacy, 47(2), 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| Chicago | AKBAL DAĞISTAN ÖZLEM,Cevher Erdal,ARAMAN AHMET OĞUL The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. Istanbul Journal of Pharmacy 47, no.2 (2017): 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| MLA | AKBAL DAĞISTAN ÖZLEM,Cevher Erdal,ARAMAN AHMET OĞUL The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. Istanbul Journal of Pharmacy, vol.47, no.2, 2017, ss.45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| AMA | AKBAL DAĞISTAN Ö,Cevher E,ARAMAN A The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. Istanbul Journal of Pharmacy. 2017; 47(2): 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| Vancouver | AKBAL DAĞISTAN Ö,Cevher E,ARAMAN A The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations. Istanbul Journal of Pharmacy. 2017; 47(2): 45 - 51. 10.5152/IstanbulJPharm.2017.007 |
| IEEE | AKBAL DAĞISTAN Ö,Cevher E,ARAMAN A "The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations." Istanbul Journal of Pharmacy, 47, ss.45 - 51, 2017. 10.5152/IstanbulJPharm.2017.007 |
| ISNAD | AKBAL DAĞISTAN, ÖZLEM vd. "The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations". Istanbul Journal of Pharmacy 47/2 (2017), 45-51. https://doi.org/10.5152/IstanbulJPharm.2017.007 |
