Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components

DERVİŞOĞLU, Sergülen; kepil, nuray; ÇOMUNOĞLU, Nil

doi:10.1016/j.aott.2018.10.007

Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components

Nil ÇOMUNOĞLU, (Istanbul University, Cerrahpasa Medical Faculty, Department of Pathology, Istanbul, Turkey)

Nuray KEPİL, (Istanbul University, Cerrahpasa Medical Faculty, Department of Pathology, Istanbul, Turkey)

Sergülen DERVİŞOĞLU (Medipol University, Department of Pathology, Istanbul, Turkey)

Acta Orthopaedica et Traumatologica Turcica

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Yıl: 2019 Cilt: 53 Sayı: 1 Sayfa Aralığı: 35 - 39 Metin Dili: İngilizce DOI: 10.1016/j.aott.2018.10.007 İndeks Tarihi: 01-11-2019

Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components

Öz:

Objective: The aim of this study was to deﬁne histopathological features of giant cell tumor of bone, especially accompanying ﬁbrohistiocytic or aneurysmal bone cyst like components, in the light of our institutions experience. Methods: A total of 120 cases (64 females and 56 males; mean age: 36.2 (12e80)) with ‘GCT’ diagnosed betweentheyears1996e2016wereincludedinthisretrospectiveanalysis.Caseswereevaluatedaccording to clinical features such as age, gender, localization, recurrence, metastasis and histopathological features. Results: Tumors were localized most frequently at proximal tibia and distal femur, respectively. In 11 cases areas rich in ﬁbrohistiocytic component and in 20 cases aneurysmal bone cyst like component were observed. In 2 cases both components were present. Twenty three cases recurred. In 1 case which was primarily located at calcaneus, tumor metastasized to lung 4 years later during follow-up. Conclusion: GCT can be confused with other tumor or tumor-like lesions involving giant cells. Secondary changes such as ﬁbrohistiocytic or aneurysmal bone cyst-like components and coagulation necrosis were frequently seen in conventional giant cell tumor of bone. For tumors having prominent ﬁbrohistiocytic and/or aneurysmal bone cyst-like components, in order to detect characteristic areas representing GCT, additional sampling is essential. Although secondary histopathological changes do not appear to affect clinical outcome, these features are important in differential diagnosis. Approximately one ﬁfth of GCTcases show recurrence and sacrum and foot bones were the most frequent sites for recurrence.

Anahtar Kelime:

Konular: Ortopedi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	ÇOMUNOĞLU N, kepil n, DERVİŞOĞLU S (2019). Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. , 35 - 39. 10.1016/j.aott.2018.10.007
Chicago	ÇOMUNOĞLU Nil,kepil nuray,DERVİŞOĞLU Sergülen Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. (2019): 35 - 39. 10.1016/j.aott.2018.10.007
MLA	ÇOMUNOĞLU Nil,kepil nuray,DERVİŞOĞLU Sergülen Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. , 2019, ss.35 - 39. 10.1016/j.aott.2018.10.007
AMA	ÇOMUNOĞLU N,kepil n,DERVİŞOĞLU S Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. . 2019; 35 - 39. 10.1016/j.aott.2018.10.007
Vancouver	ÇOMUNOĞLU N,kepil n,DERVİŞOĞLU S Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. . 2019; 35 - 39. 10.1016/j.aott.2018.10.007
IEEE	ÇOMUNOĞLU N,kepil n,DERVİŞOĞLU S "Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components." , ss.35 - 39, 2019. 10.1016/j.aott.2018.10.007
ISNAD	ÇOMUNOĞLU, Nil vd. "Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components". (2019), 35-39. https://doi.org/10.1016/j.aott.2018.10.007

APA	ÇOMUNOĞLU N, kepil n, DERVİŞOĞLU S (2019). Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. Acta Orthopaedica et Traumatologica Turcica, 53(1), 35 - 39. 10.1016/j.aott.2018.10.007
Chicago	ÇOMUNOĞLU Nil,kepil nuray,DERVİŞOĞLU Sergülen Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. Acta Orthopaedica et Traumatologica Turcica 53, no.1 (2019): 35 - 39. 10.1016/j.aott.2018.10.007
MLA	ÇOMUNOĞLU Nil,kepil nuray,DERVİŞOĞLU Sergülen Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. Acta Orthopaedica et Traumatologica Turcica, vol.53, no.1, 2019, ss.35 - 39. 10.1016/j.aott.2018.10.007
AMA	ÇOMUNOĞLU N,kepil n,DERVİŞOĞLU S Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. Acta Orthopaedica et Traumatologica Turcica. 2019; 53(1): 35 - 39. 10.1016/j.aott.2018.10.007
Vancouver	ÇOMUNOĞLU N,kepil n,DERVİŞOĞLU S Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components. Acta Orthopaedica et Traumatologica Turcica. 2019; 53(1): 35 - 39. 10.1016/j.aott.2018.10.007
IEEE	ÇOMUNOĞLU N,kepil n,DERVİŞOĞLU S "Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components." Acta Orthopaedica et Traumatologica Turcica, 53, ss.35 - 39, 2019. 10.1016/j.aott.2018.10.007
ISNAD	ÇOMUNOĞLU, Nil vd. "Histopathology of giant cell tumors of the bone: With special emphasis on ﬁbrohistiocytic and aneurysmal bone cyst like components". Acta Orthopaedica et Traumatologica Turcica 53/1 (2019), 35-39. https://doi.org/10.1016/j.aott.2018.10.007