Research on phenolic compounds found in grapes and wines has gained importance in recent years due to their antioxidative properties. Trans-resveratrol, catechin, epicatechin, quercetin and the routine are known as antioxidants, anti-inflammatory and anticarcinogenic in human health. It is found especially in red grape varieties and red wines. This situation caused a noticeable increase in the consumption of grapes and their products. In the study, varieties of grapes cultivated in Tunceli province and processed for wine were used. But the phenolic compounds of these varieties are not yet known. The scientific analysis of these varieties should be made and marketing methods should be developed. This work, human health, winemaking which a part of Anatolia, Turkey and performing of promotion worldwide is intended to contribute to the provision of increased production. For this purpose, Yusufağa, Keşpir, Ulaş Siyahı, Koşkuran, Papaz Karası which is a kind of red grapes and Hasani which is a kind of white grape varieties grown in Tunceli province, was used as plant material. Total phenolic compound, total anthocyanin and antioxidant activity levels were compared in the extracts of shells and seeds of these varieties. According to the results of the research, the highest total phenolic compound was obtained from the Papaz Karası and Ulaş Siyahı grape varieties, and the highest amount of antioxidant was obtained from the Koşkuran variety.