Yıl: 2018 Cilt: 48 Sayı: 3 Sayfa Aralığı: 503 - 508 Metin Dili: İngilizce DOI: 10.3906/sag-1706-76 İndeks Tarihi: 16-02-2020

Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality

Öz:
Background/aim: This study was undertaken to identify subjects with human immunodeficiency virus and tuberculosis (HIV/TB)coinfection in a group of HIV-positive patients followed at five different healthcare centers, and to determine the demographic andclinical characteristics of these subjects as well as the predictors of mortality.Materials and methods: A database search for subjects with TB coinfection was performed among 1475 HIV-positive adult patients anda total of 66 individuals were identified with HIV/TB coinfection.Results: There were 66 patients (4.5%) with TB coinfection. Twenty-one percent (n = 14) of the patients with TB coinfection diedduring the study period and these patients had significantly lower baseline CD4 counts at the time of TB diagnosis (P = 0.005). Noneof the patients with CD4 count of ≥200 cells/mm3 died during follow-up and a low CD4 count at the time of TB diagnosis (<200 cells/mm3) was associated with poor survival (P = 0.012). However, none of the parameters emerged as significant independent predictorsof survival in multivariate analysis.Conclusion: Coexistence of TB and HIV infection is associated with many clinical challenges and a better understanding of patientcharacteristics as well as the parameters impacting the outcome will improve the quality of care provided for this group of patients.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Friedland G, Churchyard GJ, Nardell E. Tuberculosis and HIV coinfection: current state of knowledge and research priorities. J Infect Dis 2007; 196 (Suppl. 1): S1-3.
  • Ministry of Health. Report on the Battle against Tuberculosis in Turkey. Ankara, Turkey: Ministry of Health; 2013 (in Turkish).
  • Corbett EL, Charalambous S, Moloi VM, Fielding K, Grant AD, Dye C, De Cock KM, Hayes RJ, Williams BG, Churchyard GJ. Human immunodeficiency virus and the prevalence of undiagnosed tuberculosis in African gold miners. Am J Respir Crit Care Med 2004; 170: 673-679.
  • Shuchman M. Improving global health--Margaret Chan at the WHO. N Engl J Med 2007; 356: 653-656.
  • Daley CL, Small PM, Schecter GF, Schoolnik GK, McAdam RA, Jacobs WR Jr, Hopewell PC. An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restrictionfragment- length polymorphisms. N Engl J Med 1992; 326: 231-235.
  • Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 2006; 368: 1575-1580.
  • Selwyn PA. Issues in the clinical management of intravenous drug users with HIV infection. AIDS 1989; 3 (Suppl. 1): S201- 208.
  • Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep 2009; 58: 1-207.
  • Sterling TR, Bethel J, Goldberg S, Weinfurter P, Yun L, Horsburgh CR; Tuberculosis Epidemiologic Studies Consortium. The scope and impact of treatment of latent tuberculosis infection in the United States and Canada. Am J Respir Crit Care Med 2006; 173: 927-931.
  • Toossi Z, Mayanja-Kizza H, Hirsch CS, Edmonds KL, Spahlinger T, Hom DL, Aung H, Mugyenyi P, Ellner JJ, Whalen CW. Impact of tuberculosis (TB) on HIV-1 activity in dually infected patients. Clin Exp Immunol 2001; 123: 233-238.
  • Lopez-Gatell H, Cole SR, Hessol NA, French AL, Greenblatt RM, Landesman S, Preston-Martin S, Anastos K. Effect of tuberculosis on the survival of women infected with human immunodeficiency virus. Am J Epidemiol 2007; 165: 1134-1142.
  • Badri M, Ehrlich R, Wood R, Pulerwitz T, Maartens G. Association between tuberculosis and HIV disease progression in a high tuberculosis prevalence area. Int J Tuberc Lung Dis 2001; 5: 225-232.
  • McIlleron H, Meintjes G, Burman WJ, Maartens G. Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndrome. J Infect Dis 2007; 196 (Suppl. 1): S63-75.
  • Erdem HU, Uysal S, Ertem E, Gokengin D. Mycobacterial infections in patients with HIV/AIDS: the Ege University cohort. In: 29th European Conference on Sexually Transmitted Infections, Sitges, Spain; 2013.
  • Ertunc B, Kaya S, Koksal I. Clinico-epidemiological analysis of HIV/AIDS patients. Eurasian J Med 2016; 48: 157-161.
  • Alp E, Bozkurt İ, Doğanay M. Epidemiological and clinical characteristics of HIV/AIDS patients followed-up in Cappadocia region: 18 years experience. Mikrobiyol Bul 2011; 45: 125- 136 (in Turkish with English abstract).
  • Ministry of Health. Report on the Battle against Tuberculosis in Turkey. Ankara, Turkey: Ministry of Health; 2015 (in Turkish).
  • Gao L, Zhou F, Li X, Jin Q. HIV/TB co-infection in mainland China: a meta-analysis. PLoS One 2010; 5: e10736.
  • Gao J, Zheng P, Fu H. Prevalence of TB/HIV co-infection in countries except China: a systematic review and meta-analysis. PLoS One 2013; 8: e64915.
  • Yildirim Z, Turkkani MH, Bozkurt H, Islek E, Mollahaliloglu S, Erkoc Y. Effects of the Health Transformation Programme on tuberculosis burden in Turkey. Respir Med 2013; 107: 2029- 2037.
  • Lienhardt C, Fielding K, Sillah JS, Bah B, Gustafson P, Warndorff D, Palayew M, Lisse I, Donkor S, Diallo S et al. Investigation of the risk factors for tuberculosis: a case-control study in three countries in West Africa. Int J Epidemiol 2005; 34: 914- 923.
  • Hill PC, Jackson-Sillah D, Donkor SA, Otu J, Adegbola RA, Lienhardt C. Risk factors for pulmonary tuberculosis: a clinicbased case control study in The Gambia. BMC Public Health 2006; 6: 156.
  • Lienhardt C, Fielding K, Sillah J, Tunkara A, Donkor S, Manneh K, Warndorff D, McAdam KP, Bennett S. Risk factors for tuberculosis infection in sub-Saharan Africa: a contact study in The Gambia. Am J Respir Crit Care Med 2003; 168: 448-455.
  • Naing C, Mak JW, Maung M, Wong SF, Kassim AI. Meta-analysis: the association between HIV infection and extrapulmonary tuberculosis. Lung 2013; 191: 27-34.
  • Chu R, Mills EJ, Beyene J, Pullenayegum E, Bakanda C, Nachega JB, Devereaux PJ, Thabane L. Impact of tuberculosis on mortality among HIV-infected patients receiving antiretroviral therapy in Uganda: a prospective cohort analysis. AIDS Res Ther 2013; 10: 19.
  • Straetemans M, Bierrenbach AL, Nagelkerke N, Glaziou P, van der Werf MJ. The effect of tuberculosis on mortality in HIV positive people: a meta-analysis. PLoS One 2010; 5: e15241.
  • Zenner D, Abubakar I, Conti S, Gupta RK, Yin Z, Kall M, Kruijshaar M, Rice B, Thomas HL, Pozniak A et al. Impact of TB on the survival of people living with HIV infection in England, Wales and Northern Ireland. Thorax 2015; 70: 566-573.
  • Kwan CK, Ernst JD. HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev 2011; 24: 351-376.
APA Gümüşer F, ALTINKAYNAK M, YILDIZ SEVGİ D, ALTUNTAŞ AYDIN Ö, METE B, Gunduz A, KUMBASAR KARAOSMANOĞLU H, Bolukcu S, TABAK Ö, VAHABOĞLU M (2018). Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. , 503 - 508. 10.3906/sag-1706-76
Chicago Gümüşer Fatma,ALTINKAYNAK Merve,YILDIZ SEVGİ Dilek,ALTUNTAŞ AYDIN Özlem,METE Bilgül,Gunduz Alper,KUMBASAR KARAOSMANOĞLU HAYAT,Bolukcu Sibel,TABAK ÖMER FEHMİ,VAHABOĞLU Mustafa Haluk Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. (2018): 503 - 508. 10.3906/sag-1706-76
MLA Gümüşer Fatma,ALTINKAYNAK Merve,YILDIZ SEVGİ Dilek,ALTUNTAŞ AYDIN Özlem,METE Bilgül,Gunduz Alper,KUMBASAR KARAOSMANOĞLU HAYAT,Bolukcu Sibel,TABAK ÖMER FEHMİ,VAHABOĞLU Mustafa Haluk Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. , 2018, ss.503 - 508. 10.3906/sag-1706-76
AMA Gümüşer F,ALTINKAYNAK M,YILDIZ SEVGİ D,ALTUNTAŞ AYDIN Ö,METE B,Gunduz A,KUMBASAR KARAOSMANOĞLU H,Bolukcu S,TABAK Ö,VAHABOĞLU M Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. . 2018; 503 - 508. 10.3906/sag-1706-76
Vancouver Gümüşer F,ALTINKAYNAK M,YILDIZ SEVGİ D,ALTUNTAŞ AYDIN Ö,METE B,Gunduz A,KUMBASAR KARAOSMANOĞLU H,Bolukcu S,TABAK Ö,VAHABOĞLU M Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. . 2018; 503 - 508. 10.3906/sag-1706-76
IEEE Gümüşer F,ALTINKAYNAK M,YILDIZ SEVGİ D,ALTUNTAŞ AYDIN Ö,METE B,Gunduz A,KUMBASAR KARAOSMANOĞLU H,Bolukcu S,TABAK Ö,VAHABOĞLU M "Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality." , ss.503 - 508, 2018. 10.3906/sag-1706-76
ISNAD Gümüşer, Fatma vd. "Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality". (2018), 503-508. https://doi.org/10.3906/sag-1706-76
APA Gümüşer F, ALTINKAYNAK M, YILDIZ SEVGİ D, ALTUNTAŞ AYDIN Ö, METE B, Gunduz A, KUMBASAR KARAOSMANOĞLU H, Bolukcu S, TABAK Ö, VAHABOĞLU M (2018). Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. Turkish Journal of Medical Sciences, 48(3), 503 - 508. 10.3906/sag-1706-76
Chicago Gümüşer Fatma,ALTINKAYNAK Merve,YILDIZ SEVGİ Dilek,ALTUNTAŞ AYDIN Özlem,METE Bilgül,Gunduz Alper,KUMBASAR KARAOSMANOĞLU HAYAT,Bolukcu Sibel,TABAK ÖMER FEHMİ,VAHABOĞLU Mustafa Haluk Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. Turkish Journal of Medical Sciences 48, no.3 (2018): 503 - 508. 10.3906/sag-1706-76
MLA Gümüşer Fatma,ALTINKAYNAK Merve,YILDIZ SEVGİ Dilek,ALTUNTAŞ AYDIN Özlem,METE Bilgül,Gunduz Alper,KUMBASAR KARAOSMANOĞLU HAYAT,Bolukcu Sibel,TABAK ÖMER FEHMİ,VAHABOĞLU Mustafa Haluk Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. Turkish Journal of Medical Sciences, vol.48, no.3, 2018, ss.503 - 508. 10.3906/sag-1706-76
AMA Gümüşer F,ALTINKAYNAK M,YILDIZ SEVGİ D,ALTUNTAŞ AYDIN Ö,METE B,Gunduz A,KUMBASAR KARAOSMANOĞLU H,Bolukcu S,TABAK Ö,VAHABOĞLU M Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. Turkish Journal of Medical Sciences. 2018; 48(3): 503 - 508. 10.3906/sag-1706-76
Vancouver Gümüşer F,ALTINKAYNAK M,YILDIZ SEVGİ D,ALTUNTAŞ AYDIN Ö,METE B,Gunduz A,KUMBASAR KARAOSMANOĞLU H,Bolukcu S,TABAK Ö,VAHABOĞLU M Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality. Turkish Journal of Medical Sciences. 2018; 48(3): 503 - 508. 10.3906/sag-1706-76
IEEE Gümüşer F,ALTINKAYNAK M,YILDIZ SEVGİ D,ALTUNTAŞ AYDIN Ö,METE B,Gunduz A,KUMBASAR KARAOSMANOĞLU H,Bolukcu S,TABAK Ö,VAHABOĞLU M "Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality." Turkish Journal of Medical Sciences, 48, ss.503 - 508, 2018. 10.3906/sag-1706-76
ISNAD Gümüşer, Fatma vd. "Human immunodeficiency virus and tuberculosis coinfection: clinical features and predictors of mortality". Turkish Journal of Medical Sciences 48/3 (2018), 503-508. https://doi.org/10.3906/sag-1706-76