Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

MELEK, SULE; YÖNEZ, Muhammed Kaan; EROL, Muharrem; DOĞAN, Zafer; Atalan, Gultekin; EROL, HANIFI

Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

Muharrem EROL, (Balıkesir University)

Hanifi EROL, (Erciyes University)

Gültekin ATALAN, (Erciyes University)

Zafer DOĞAN, (Diğer)

Muhammed Kaan YÖNEZ, (Erciyes University)

Şule MELEK (Bingöl University)

Harran Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2018 Cilt: 7 Sayı: 1 Sayfa Aralığı: 21 - 25 Metin Dili: İngilizce İndeks Tarihi: 17-02-2020

Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

Öz:

The aim of this study was to determine of the effects of midazolam, ketamine and isoflurane anesthetic agents ontear production and intraocular pressure in rabbits. In this study twenty healthy (n=20) male white New Zealand rabbits(mean weight 2.20 ± 0.50 kg, age 16 weeks) were used. Anesthesia was performed intramuscular (IM) midazolam 3 mg/kg,and ketamine 30 mg/kg in group I. In second group (Group II), after midazolam and ketamine injections isoflurane 2% wasused for general anesthesia. After anesthesia means intraocular pressure (IOP) decreased in both groups. Intraocularpressure in first group (Group I) was 10.3 ± 0.85 mmHg (right eyes), 11.4 ± 0.95 mmHg (left eyes) while it was 8.5 ± 0.85mmHg (right eyes), 8.3 ± 0.85 mmHg (left eyes) n group II. The result of this study show that systemically used midazolam,ketamine and isoflurane anesthetic agents decrease IOP and tear secretion in rabbits.

Anahtar Kelime:

Konular: Ziraat Mühendisliği

Tavşanlarda Sistemik Olarak Kullanılan Midazolam, Ketamin ve İsofluranın Gözyaşı Üretimi ve Göziçi Basıncı Üzerine Olan Etkilerinin Deneysel Olarak Araştırılması

Öz:

Bu çalışmanın amacı; tavşanlarda midazolam, ketamin ve isofluran anestezik ajanların gözyaşı üretimi ve göziçi basıncı üzerine olan etkilerini belirlemektir. Bu çalışmada yirmi adet (n = 20) sağlıklı, (ortalama ağırlıkları 2.20 ± 0.50 kg, yaşları 16 hafta) erkek Yeni Zelanda tavşanı kullanıldı. Birinci grupta intramuskuler (İM) midazolam 3mg/kg, ve ketamine İM 30 mg/ kg uygulanarak anestezi sağlandı. Ikinci grupta (Grup 2), midazolam ve ketamine enjeksiyonundan sonra genel anestezi için %2’lik İsofluran uygulandı. Anesteziden sonra her iki grupta da intraoküler basınç değerlerinde düşüşler görüldü. Birinci grupta (Grup I) göz içi basıncı sağ gözde 10.3 ± 0.85 mmHg ölçülürken, sol gözde 11.4 ± 0.95 mmHg olarak ölçüldü. İkinci grupta (Grup II) göziçi basıncı sağ gözde 8.5 ± 0.85 mmHg ölçülürken, sol gözde 8.3 ± 0.85 mmHg (sol göz) vardı. Bu çalışmanın sonucunda tavşanlarda sistemik olarak kullanılan midazolam, ketamin ve isofluran gibi anestezik ajanların GİB ve gözyaşı salgısını azalttığı görüldü.

Anahtar Kelime:

Konular: Ziraat Mühendisliği

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EROL M, EROL H, Atalan G, DOĞAN Z, YÖNEZ M, MELEK S (2018). Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. , 21 - 25.
Chicago	EROL Muharrem,EROL HANIFI,Atalan Gultekin,DOĞAN Zafer,YÖNEZ Muhammed Kaan,MELEK SULE Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. (2018): 21 - 25.
MLA	EROL Muharrem,EROL HANIFI,Atalan Gultekin,DOĞAN Zafer,YÖNEZ Muhammed Kaan,MELEK SULE Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. , 2018, ss.21 - 25.
AMA	EROL M,EROL H,Atalan G,DOĞAN Z,YÖNEZ M,MELEK S Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. . 2018; 21 - 25.
Vancouver	EROL M,EROL H,Atalan G,DOĞAN Z,YÖNEZ M,MELEK S Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. . 2018; 21 - 25.
IEEE	EROL M,EROL H,Atalan G,DOĞAN Z,YÖNEZ M,MELEK S "Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits." , ss.21 - 25, 2018.
ISNAD	EROL, Muharrem vd. "Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits". (2018), 21-25.

APA	EROL M, EROL H, Atalan G, DOĞAN Z, YÖNEZ M, MELEK S (2018). Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. Harran Üniversitesi Veteriner Fakültesi Dergisi, 7(1), 21 - 25.
Chicago	EROL Muharrem,EROL HANIFI,Atalan Gultekin,DOĞAN Zafer,YÖNEZ Muhammed Kaan,MELEK SULE Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. Harran Üniversitesi Veteriner Fakültesi Dergisi 7, no.1 (2018): 21 - 25.
MLA	EROL Muharrem,EROL HANIFI,Atalan Gultekin,DOĞAN Zafer,YÖNEZ Muhammed Kaan,MELEK SULE Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. Harran Üniversitesi Veteriner Fakültesi Dergisi, vol.7, no.1, 2018, ss.21 - 25.
AMA	EROL M,EROL H,Atalan G,DOĞAN Z,YÖNEZ M,MELEK S Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2018; 7(1): 21 - 25.
Vancouver	EROL M,EROL H,Atalan G,DOĞAN Z,YÖNEZ M,MELEK S Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2018; 7(1): 21 - 25.
IEEE	EROL M,EROL H,Atalan G,DOĞAN Z,YÖNEZ M,MELEK S "Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits." Harran Üniversitesi Veteriner Fakültesi Dergisi, 7, ss.21 - 25, 2018.
ISNAD	EROL, Muharrem vd. "Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits". Harran Üniversitesi Veteriner Fakültesi Dergisi 7/1 (2018), 21-25.