Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model
Yıl: 2019 Cilt: 33 Sayı: 2 Sayfa Aralığı: 139 - 147 Metin Dili: İngilizce DOI: 10.5505/deutfd.2019.86619 İndeks Tarihi: 17-02-2020
Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model
Öz: Objective: Seroma formation is one of the most frequent complications followingbreast cancer surgery. Although many techniques and drugs have beeninvestigated, no definitive data are available concerning how to prevent thiscomplication. The present study aims to investigate impact of local clinoptiloliteapplication on seroma formation in an experimental mastectomy model createdin rats.Material and Method: Two groups with seven rats in each were randomised.Under general anesthesia, all rats underwent right mastectomy and axillarydissection. Clinoptilolite was locally applied to surgical sites in the study group,whereas no application was performed in the control group. Ten days after thesurgery, seroma formation was evaluated and tissue samples were obtained fromthe surgical sites, for both biochemical and histopathological examinationResults: There was statistically significant decrease in seroma formation afterclinoptilolite application (p=0.002). In addition, granulation tissue formation wassignificantly higher in the study group (p=0.006). No statistical difference wasfound between groups in terms of biochemical parameters.Conclusion: The reducing effect of seroma formation by clinoptilolite applicationmay be due to its crystal cage structure. It collects seroma with its sero-absorbentfeatures and creates granuloma formation that reduces dead- space, thereforeaccelarating wound healing.
Anahtar Kelime: RATLARDA MASTEKTOMİ VE AKSİLLER DİSSEKSİYON SONRASI KLİNOPTİLOLİT (FROKSİMUN®) KULLANIMININ SEROMA OLUŞUMUNA ETKİSİ
Öz: Amaç: Seroma oluşumu, meme kanseri cerrahisini takiben en sık görülen komplikasyonlardan biridir. Birçok teknik ve ilaç araştırılmasına rağmen bu komplikasyonun nasıl önleneceğine dair kesin bir veri bulunmamaktadır. Bu çalışmada, sıçanlarda oluşturulan deneysel mastektomi modelinde, lokal klinoptilolit uygulamasının seroma formasyonu üzerindeki etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda, sıçanlar çalışma grubu (n=7) ve kontrol grubu (n=7) olarak iki gruba randomize edildi. Genel anestezi altında tüm sıçanlara sağ mastektomi ve aksiller disseksiyon yapıldı. Çalışma grubuna lokal olarak klinoptilolit uygulanırken, kontrol grubuna herhangi bir uygulama yapılmadı. Ameliyattan on gün sonra, seroma formasyonu değerlendirildi ve hem biyokimyasal hem de histopatolojik incelemeler için cerrahi alanlardan doku örnekleri alındı. Bulgular: Klinoptilolit uygulanan çalışma grubunda, kontrol grubuna göre seroma oluşumunda istatistiksel olarak anlamlı azalma saptandı (p = 0,002). Ek olarak, çalışma grubunda granülasyon dokusu oluşumu anlamlı olarak daha yüksekti (p = 0,006). Biyokimyasal parametreler açısından gruplar arasında istatistiksel bir fark bulunmadı. Sonuç: Seroma oluşumunun klinoptilolit uygulaması sonrası azalması, kristal kafes yapısına bağlı olabilir. Sero-emici özellikleriyle seromayı toplar ve ölü boşluğu azaltan, dolayısıyla yara iyileşmesini hızlandıran granülom yapılarını oluşturur.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | AKSOY s, TUNK C, SEVİNÇ A, GÜRAY DURAK M (2019). Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. , 139 - 147. 10.5505/deutfd.2019.86619 |
| Chicago | AKSOY suleyman ozkan,TUNK Cevdet Onur,SEVİNÇ Ali İbrahim,GÜRAY DURAK Merih Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. (2019): 139 - 147. 10.5505/deutfd.2019.86619 |
| MLA | AKSOY suleyman ozkan,TUNK Cevdet Onur,SEVİNÇ Ali İbrahim,GÜRAY DURAK Merih Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. , 2019, ss.139 - 147. 10.5505/deutfd.2019.86619 |
| AMA | AKSOY s,TUNK C,SEVİNÇ A,GÜRAY DURAK M Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. . 2019; 139 - 147. 10.5505/deutfd.2019.86619 |
| Vancouver | AKSOY s,TUNK C,SEVİNÇ A,GÜRAY DURAK M Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. . 2019; 139 - 147. 10.5505/deutfd.2019.86619 |
| IEEE | AKSOY s,TUNK C,SEVİNÇ A,GÜRAY DURAK M "Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model." , ss.139 - 147, 2019. 10.5505/deutfd.2019.86619 |
| ISNAD | AKSOY, suleyman ozkan vd. "Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model". (2019), 139-147. https://doi.org/10.5505/deutfd.2019.86619 |
| APA | AKSOY s, TUNK C, SEVİNÇ A, GÜRAY DURAK M (2019). Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 33(2), 139 - 147. 10.5505/deutfd.2019.86619 |
| Chicago | AKSOY suleyman ozkan,TUNK Cevdet Onur,SEVİNÇ Ali İbrahim,GÜRAY DURAK Merih Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 33, no.2 (2019): 139 - 147. 10.5505/deutfd.2019.86619 |
| MLA | AKSOY suleyman ozkan,TUNK Cevdet Onur,SEVİNÇ Ali İbrahim,GÜRAY DURAK Merih Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, vol.33, no.2, 2019, ss.139 - 147. 10.5505/deutfd.2019.86619 |
| AMA | AKSOY s,TUNK C,SEVİNÇ A,GÜRAY DURAK M Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi. 2019; 33(2): 139 - 147. 10.5505/deutfd.2019.86619 |
| Vancouver | AKSOY s,TUNK C,SEVİNÇ A,GÜRAY DURAK M Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi. 2019; 33(2): 139 - 147. 10.5505/deutfd.2019.86619 |
| IEEE | AKSOY s,TUNK C,SEVİNÇ A,GÜRAY DURAK M "Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model." Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 33, ss.139 - 147, 2019. 10.5505/deutfd.2019.86619 |
| ISNAD | AKSOY, suleyman ozkan vd. "Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model". Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 33/2 (2019), 139-147. https://doi.org/10.5505/deutfd.2019.86619 |
