Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety

Nuray ULUSOY GÜZELDEMİRCİ, (İstanbul Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)
Erkan PEHLİVAN, (İstanbul Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)
Lieve NAESENS (Rega Institute for Medical Research, KU Leuven, Belgium)
Marmara Pharmaceutical Journal
4 0
Yıl: 2018 Cilt: 22 Sayı: 2 Sayfa Aralığı: 237 - 248 Metin Dili: İngilizce DOI: 10.12991/mpj.2018.61 İndeks Tarihi: 27-02-2020

Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety

Öz:
A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNA- andRNA-viruses in mammalian cell cultures. Some of the compounds were found to exhibit moderate antiviral activity. 3-Propyl-2-[((6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-methyl-4-thiazolidinone 13, displayedmodest yet consistent activity against three strains of influenza A virus, including the 2009 pandemic virus A/H1N1Virginia/ATCC3/2009 (cytotoxicity >100 μM). Compounds 6 and 11 displayed activity against vesicular stomatitisvirus in HeLa cells (antiviral EC50 values of 9 (cytotoxicity 100 μM) and 2 μM (cytotoxicity 20 μM), respectively). Neitherof the compounds was active against HIV.
Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Ulusoy Güzeldemirci N, Pehlivan E, NAESENS L (2018). Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. , 237 - 248. 10.12991/mpj.2018.61
Chicago Ulusoy Güzeldemirci Nuray,Pehlivan Erkan,NAESENS Lieve Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. (2018): 237 - 248. 10.12991/mpj.2018.61
MLA Ulusoy Güzeldemirci Nuray,Pehlivan Erkan,NAESENS Lieve Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. , 2018, ss.237 - 248. 10.12991/mpj.2018.61
AMA Ulusoy Güzeldemirci N,Pehlivan E,NAESENS L Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. . 2018; 237 - 248. 10.12991/mpj.2018.61
Vancouver Ulusoy Güzeldemirci N,Pehlivan E,NAESENS L Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. . 2018; 237 - 248. 10.12991/mpj.2018.61
IEEE Ulusoy Güzeldemirci N,Pehlivan E,NAESENS L "Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety." , ss.237 - 248, 2018. 10.12991/mpj.2018.61
ISNAD Ulusoy Güzeldemirci, Nuray vd. "Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety". (2018), 237-248. https://doi.org/10.12991/mpj.2018.61
APA Ulusoy Güzeldemirci N, Pehlivan E, NAESENS L (2018). Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Marmara Pharmaceutical Journal, 22(2), 237 - 248. 10.12991/mpj.2018.61
Chicago Ulusoy Güzeldemirci Nuray,Pehlivan Erkan,NAESENS Lieve Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Marmara Pharmaceutical Journal 22, no.2 (2018): 237 - 248. 10.12991/mpj.2018.61
MLA Ulusoy Güzeldemirci Nuray,Pehlivan Erkan,NAESENS Lieve Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Marmara Pharmaceutical Journal, vol.22, no.2, 2018, ss.237 - 248. 10.12991/mpj.2018.61
AMA Ulusoy Güzeldemirci N,Pehlivan E,NAESENS L Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Marmara Pharmaceutical Journal. 2018; 22(2): 237 - 248. 10.12991/mpj.2018.61
Vancouver Ulusoy Güzeldemirci N,Pehlivan E,NAESENS L Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Marmara Pharmaceutical Journal. 2018; 22(2): 237 - 248. 10.12991/mpj.2018.61
IEEE Ulusoy Güzeldemirci N,Pehlivan E,NAESENS L "Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety." Marmara Pharmaceutical Journal, 22, ss.237 - 248, 2018. 10.12991/mpj.2018.61
ISNAD Ulusoy Güzeldemirci, Nuray vd. "Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety". Marmara Pharmaceutical Journal 22/2 (2018), 237-248. https://doi.org/10.12991/mpj.2018.61
Sayfa Oluşturulma Tarihi
23-04-2024 10:38

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