Objective It was aimed to determine the frequency of use of complementary and alternative medicine methods in musculoskeletal system diseases and the most commonly used method.( Sakarya Med J, 2018, 8(3):481-488 ). Materials and Methods Patients who applied to the hospital between September 30, 2017 and December 30, 2017 were included in this study. A total of 512 male and female patients (367 female ve 145 male) with chronic musculoskeletal diseases over the age of 18 were included in the study. The data collected with the form of complementary and alternative medicine (CAM) methods. It was requested by the physician to answer the questions in the questionnaire and it was noted by the physician. Data were evaluated using the numeric, percentage distributions, chi-square and pearson correlation tests. Results The mean age of the participants was 53,25 ± 14,61 year. One hundred sixty-seven (71.7%) of the participants were female and 145 (28.3%) were male. 65.8% of those participating in the study had comorbid disease. Eighty-seven point nine percent (87.9%) had the use of TAT.CAM practitioners were 19.6% physicians, 13.2% physiotherapists, 4.2% nurses, 9.1% religious offi cers and 53.9% others. The most preferred method was 73,9% of mineral spring. Advantages of using TAT methods with advanced age were signifi cantly higher in cupping and yoga applications. Conclusion Patients with chronic musculoskeletal diseases frequently refer to CAM methods. However, most of the applicants, apart from the physician’s suggestion, take place with the suggestion of close family members and the environment. It was also found that more than half of the patients in this study were practiced by persons not trained in the fi eld. In addition, it was observed that TAT use was higher in advanced age and comorbid diseases.