Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study
Yıl: 2019 Cilt: 25 Sayı: 4 Sayfa Aralığı: 218 - 228 Metin Dili: İngilizce DOI: 10.4274/tnd.galenos.2019.33341 İndeks Tarihi: 02-05-2020
Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study
Öz: Objective: Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. Lipid profile and anthropometric measurements might differfor patients with MS and healthy people. This study aimed to compare the lipid profiles and anthropometric measurements of patients with MS and healthyparticipants.Materials and Methods: The study was designed as a controlled descriptive study, consisting of 392 people (196 patients in the MS-MS group, and 196healthy volunteers in the control group) who presented to a state hospital in Turkey. Blood samples were collected and lipid profiles (total cholesterol, high-densitylipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides) were analyzed. Body mass index (BMI), waist-to-hip and waist-to-height ratios werecalculated, and the parameters were compared between the groups. The relationship between the parameters and the presence of MS was investigated.Results: The weights, heights, hip circumferences, waist-to-hip and waist-to-height ratios of the people differed statistically significantly between the groups(p<0.05). There were no statistically significant differences between the groups in terms of the considered lipid profiles. The difference between the BMI values ofmales in the control and MS groups was statistically significant (p=0.006).Conclusion: The obtained results indicate that anthropometric measurements of patients with MS differ significantly from healthy individuals, althoughno significant difference could be observed in terms of lipid profiles. Most of the findings of this study are consistent with the literature and suggest that theanthropometric changes in individuals should be followed regularly to prevent a possible MS risk.
Anahtar Kelime: Konular:
Multipl Skleroz Hastalarının Yağ Profilleri ve Antropometrik Ölçümlerinin Belirlenmesi: Kontrollü Tanımlayıcı Çalışma
Öz: Amaç: Multipl skleroz (MS), merkezi sinir sisteminin nörodejeneratif bir hastalığıdır. Yağ profili ve antropometrik ölçümler, MS hastaları ve sağlıklı insanlar için farklılık gösterebilmektedir. Bu çalışmada MS hastalarının lipid profilleri ile antropometrik ölçümlerinin sağlıklı bireylerle karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Türkiye’deki bir devlet hastanesine başvuran 392 kişiden (MS grubu-196 hasta, kontrol grubu-196 sağlıklı gönüllü birey) oluşan bu çalışma kontrollü tanımlayıcı bir çalışma olarak tasarlanmıştır. Her bir bireyden kan örnekleri toplanmış ve lipid profilleri (toplam kolesterol, yüksek yoğunluklu lipoprotein kolesterol, düşük yoğunluklu lipoprotein kolesterol ve trigliseritler) analiz edilmiştir. Vücut kitle indeksi (VKİ), bel-kalça ve bel-boy oranları hesaplanmış ve bu gruplar arasında bu parametreler açısından önemli bir farkın olup olmadığı test edilmiştir. Ayrıca, çalışmada ele alınan parametreler ile MS varlığı arasındaki ilişki de araştırılmıştır. Bulgular: Bireylerin ağırlık, boy, kalça çevresi, bel-kalça ve bel-boy oranları gruplar arasında istatistiksel olarak anlamlı farklılık göstermiştir (p<0,05). Çalışmada ele alınan lipid profilleri açısından gruplar arasında istatistiksel olarak anlamlı bir fark bulunamamıştır. Kontrol grubundaki erkekler ile MS grubundaki erkeklerin VKİ değerleri arasındaki farkın istatistiksel olarak anlamlı olduğu tespit edilmiştir (p=0,006). Sonuç: Elde edilen sonuçlar, MS hastalarının antropometrik ölçümlerinin sağlıklı bireylerden önemli ölçüde farklı olduğunu, ancak yağ profilleri açısından gruplar arasında anlamlı bir farkın bulunmadığını göstermektedir. Bu çalışmadan elde edilen bulguların çoğu literatürdeki sonuçlarla eşleşmektedir ve olası bir MS riskinden korunmak için bireylerdeki antropometrik değişikliklerin düzenli olarak izlenmesi gerektiğini önermektedir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. World Health Organization (WHO). Neurological disorders: Public health challenges. Date accessed: December 13, 2019. Available from: https://www. who.int/mental_health/neurology/neurological_disorders_report_web.pdf
- 2. Weinshenker BC. Epidemiology of multiple sclerosis. Neurol Clin 1996;142:1-308.
- 3. Al-Omaishi J, Bashir R, Gendelman HE. The cellular immunology of multiple sclerosis. J Leukoc Biol 1999;65:444-452.
- 4. Dorrucci M, Longo B, Arpino C, Boros S, Rezza G. Combined antiretroviral therapy and the incidence of acquired immunodeficiency syndrome-related central nervous system diseases. Ann Neurol 2004;56:307-307.
- 5. Van Amerongen BM, Dijkstra C, Lips P PC. Multiple sclerosis and vitamin D: an update. Eur J Clin Nutr 2004;58:1095-1109.
- 6. Cree BAC. Multiple sclerosis. In: Brust JCM, ed. Current Diagnosis and Treatment in Neurology. New York: Lange Medical Books/McGraw-Hill Medical, 2007.
- 7. Pekcan G. Beslenme Durumunun Saptanması. 1st ed. Ankara: Klasmat Matbaacılık, 2008.
- 8. Hunt DR, Maslovitz A, Rowlands BJ, Brooks B. A simple nutrition screening procedure for hospital patients. J Am Diet Assoc 1985;85:332-335.
- 9. Kamalian N, Keesey RE, ZuRhein GM. Lateral hypothalamic demyelination and cachexia in a case of malignant multiple sclerosis. Neurology 1975;25:25-30.
- 10. Weinstock-Guttman B, Zivadinov R, Mahfooz N, et al. Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis. J Neuroinflammation 2011;8:127.
- 11. Çomoğlu S, Yardimci S, Okçu Z. Body Fat Distribution and Plasma Lipid Profiles of Patients with Multiple Sclerosis. Turk J Med Sci 2004;34:43-48.
- 12. Newcombe J, Li H, Cuzner ML. Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis. Neuropathol Appl Neurobiol 1994;20:152-162.
- 13. Quintana FJ, Yeste A, Weiner HL, Covacu R. Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. J Neuroimmunol 2012;248:53-57.
- 14. Jorissen W, Wouters E, Bogie JF, et al. Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL. Sci Rep 2017;7:1-14.
- 15. Palavra F, Marado D, Mascarenhas-Melo F, et al. New markers of early cardiovascular risk in multiple sclerosis patients: Oxidized-LDL correlates with clinical staging. Dis Markers 2013;34:341-348.
- 16. Navarro X, Segura R. Plasma lipids and their fatty acid composition in multiple sclerosis. Acta Neurol Scand 1988;78:152-157.
- 17. Dogan HO. Serum lipids and Lp-PLA2 activity in multiple sclerosis. Turkish J Biochem 2014;39:472-475.
- 18. Saka M, Saka M, Koseler E, et al. Nutritional status and anthropometric measurements of patients with multiple sclerosis. Saudi Med J 2012;33:160- 166.
- 19. World Health Organization (WHO). Global database on body mass index. Date accessed: November 15, 2018. Available from: http://apps.who.int/bmi/ index.jsp?introPage=intro
- 20. World Health Organization (WHO). Waist circumference and waist-hip ratio. Date accessed: November 20, 2018. Availabe from: https://apps.who. int/iris/bitstream/handle/10665/44583/9789241501491_eng.pdf?ua=1
- 21. Ashwell M DHS. Six reasons why the waist-to-height ratio is a rapid and effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity. Int J Food Sci Nutr 2005;56:303-307.
- 22. Ahmed AM, Muawia M, Mohammed H, Elzein AM EA. Determination of lipid profile among Sudanese patients with prostate cancer in Khartoum State. Sch Acad J Pharm 2017;6:546-548.
- 23. Roubenoff R, Rall LC. Humoral Mediation of Changing Body Composition During Aging and Chronic Inflammation. Nutr Rev 1993;51:1-11.
- 24. Ozgocmen S, Bulut S, Ilhan N, Gulkesen A, Ardicoglu O, Özkan Y. Vitamin D deficiency and reduced bone mineral density in multiple sclerosis: effect of ambulatory status and functional capacity. J Bone Miner Metab 2005;23:309- 313.
- 25. Ghadirian P, Jain M, Ducic S, Shatenstein B, Morisset R. Nutritional factors in the aetiology of multiple sclerosis: a case- control study in Montreal, Canada. Int J Epidemiol 1998;27:845-852.
- 26. Formica CA, Cosman F, Nieves J, Herbert J, Lindsay R. Reduced bone mass and fat-free mass in women with multiple sclerosis: Effects of ambulatory status and glucocorticoid use. Calcif Tissue Int 1997;61:129-133.
- 27. Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology 2009;73:1543-1550.
- 28. Khurana SR, Bamer AM, Turner AP, et al. The Prevalence of Overweight and Obesity in Veterans with Multiple Sclerosis. Am J Phys Med Rehabil 2009;88:83-91.
- 29. Hedström AK, Olsson T, Alfredsson L. High body mass index before age
- 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler J 2012;18:1334-1336.
- 30. Munger KL, Bentzen J, Laursen B, et al. Childhood body mass index and multiple sclerosis risk: A long-term cohort study. Mult Scler J 2013;19:1323- 1329.
- 31. Mokry LE, Ross S, Timpson NJ, et al. Obesity and Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med 2016;13:1-16.
- 32. Mohammad Shirazi M, Taleban F, Ghafarpoor M. Macronutrients Intake in Iranian Multiple Sclerosis Patients. J Med Sci 2007;7:422-426.
- 33. Barnes MS, Bonham MP, Robson PJ, Strain JJ, Lowe-strong AS. Assessment of 25-hydroxyvitamin D and 1 , 25-dihydroxyvitamin D 3 concentrations in male and female multiple sclerosis patients and control volunteers. Mult Scler J 2007;13:670-672.
- 34. Pekmezovic TD, Tepavcevic DBK, Mesaros ST, et al. Food and dietary patterns and multiple sclerosis: a case-control study in Belgrade (Serbia). Ital J Public Health 2012;6:81-87.
| APA | DELİKANLI AKBAY G, Karakullukçu E, AKYOL MUTLU A, TANJU BESLER H (2019). Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. , 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| Chicago | DELİKANLI AKBAY Gülşen,Karakullukçu Erdinç,AKYOL MUTLU Aslı,TANJU BESLER Halit Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. (2019): 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| MLA | DELİKANLI AKBAY Gülşen,Karakullukçu Erdinç,AKYOL MUTLU Aslı,TANJU BESLER Halit Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. , 2019, ss.218 - 228. 10.4274/tnd.galenos.2019.33341 |
| AMA | DELİKANLI AKBAY G,Karakullukçu E,AKYOL MUTLU A,TANJU BESLER H Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. . 2019; 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| Vancouver | DELİKANLI AKBAY G,Karakullukçu E,AKYOL MUTLU A,TANJU BESLER H Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. . 2019; 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| IEEE | DELİKANLI AKBAY G,Karakullukçu E,AKYOL MUTLU A,TANJU BESLER H "Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study." , ss.218 - 228, 2019. 10.4274/tnd.galenos.2019.33341 |
| ISNAD | DELİKANLI AKBAY, Gülşen vd. "Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study". (2019), 218-228. https://doi.org/10.4274/tnd.galenos.2019.33341 |
| APA | DELİKANLI AKBAY G, Karakullukçu E, AKYOL MUTLU A, TANJU BESLER H (2019). Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. Türk Nöroloji Dergisi, 25(4), 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| Chicago | DELİKANLI AKBAY Gülşen,Karakullukçu Erdinç,AKYOL MUTLU Aslı,TANJU BESLER Halit Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. Türk Nöroloji Dergisi 25, no.4 (2019): 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| MLA | DELİKANLI AKBAY Gülşen,Karakullukçu Erdinç,AKYOL MUTLU Aslı,TANJU BESLER Halit Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. Türk Nöroloji Dergisi, vol.25, no.4, 2019, ss.218 - 228. 10.4274/tnd.galenos.2019.33341 |
| AMA | DELİKANLI AKBAY G,Karakullukçu E,AKYOL MUTLU A,TANJU BESLER H Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. Türk Nöroloji Dergisi. 2019; 25(4): 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| Vancouver | DELİKANLI AKBAY G,Karakullukçu E,AKYOL MUTLU A,TANJU BESLER H Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study. Türk Nöroloji Dergisi. 2019; 25(4): 218 - 228. 10.4274/tnd.galenos.2019.33341 |
| IEEE | DELİKANLI AKBAY G,Karakullukçu E,AKYOL MUTLU A,TANJU BESLER H "Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study." Türk Nöroloji Dergisi, 25, ss.218 - 228, 2019. 10.4274/tnd.galenos.2019.33341 |
| ISNAD | DELİKANLI AKBAY, Gülşen vd. "Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study". Türk Nöroloji Dergisi 25/4 (2019), 218-228. https://doi.org/10.4274/tnd.galenos.2019.33341 |
