Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication
Yıl: 2019 Cilt: 39 Sayı: 1 Sayfa Aralığı: 9 - 18 Metin Dili: İngilizce DOI: 10.5336/medsci.2018-62181 İndeks Tarihi: 22-05-2020
Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication
Öz: Objective: The studies about use of pregabalin for premedication have been recently carried out dueto pregabalin has analgesic and anxiolytic effects together. We aimed to evaluate the effects of preoperative pregabalin on anxiety score, hemodynamic parameters, postoperative pain and analgesic consumption in patientsundergoing elective abdominal hysterectomy. Material and Methods: The patients were randomly separatedinto 34 patients of two groups. This prospective randomized, double-blind and placebo-controlled study was performed in patients undergoing elective abdominal hysterectomy. Pregabalin 150 mg (Pregabalin Group) orplacebo 150 mg empty capsule (Control Group) was given to the patients 12 hours and 1 hour before operation.STAI-I (State-Trait Anxiety Inventory-I) anxiety scale were performed to the patients during preoperative examination and 1 hour before operation. In both groups, intraoperative hemodynamic parameters, postoperativepain levels with VAS (Visual Analogue Scale), morphine consumption and developing side effects were recordedand analyzed. Results: When all patients were compared from the point of demographic data, no difference wasfound between groups. STAI-I points were found significantly different between Pregabalin and Control groupsboth premedication and postmedication phases. MAP (Mean Arterial Pressure) data were found lower in pregabalin group at intraoperative 30th, 40th and 75th minutes and postoperative 1st minute (p<0.05). PostoperativeVAS values were found lower in Pregabalin Group. Additional analgesic use and morphine consumption, werelower in Pregabalin group except 1st and 30th minutes. When both groups, examined with regard to side effects,side effect rates of Control Group were 29% and rates of Pregabalin Group were 10%. Conclusion: In this study,it was concluded that pregabalin use at 12 and 1 hour before operation decreased preoperative anxiety score, provided postoperative analgesia and found superior to placebo due to decreasing side effects via decreasing the consumption of analgesics, however for the routine use of pregabalin in premedication it was needed further studieswith different doses and large sample sizes.
Anahtar Kelime: Konular:
Pregabalin Premedikasyonunun Preoperatif Anksiyolitik ve Postoperatif Analjezik Etkilerinin Değerlendirilmesi
Öz: Amaç: Pregabalinin analjezik ve anksiyolitik etkinliği birarada taşıması nedeniyle son dönemde premedikasyonda kullanımı ile ilgili çalışmalar yapılmaktadır. Elektif abdominal histerektomi geçirecek hastalarda preoperatif pregabalin kullanımının anksiyete skoru, hemodinamik parametreler, postoperatif ağrı ve analjezik tüketimi üzerine etkilerini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Hastalar rastgele 34 kişilik 2 gruba ayrıldı. Bu prospektif randomize, çift kör ve plasebo kontrollü çalışma elektif abdominal histerektomi geçirecek hastalarda gerçekleştirildi. Hastalara operasyondan 12 saat ve 1 saat önce pregabalin 150 mg (Pregabalin grubu) veya plasebo 150 mg boş kapsül (Kontrol grubu) verildi. Hastalara preoperatif muayene sırasında ve operasyondan 1 saat önce State-Trait Anxiety Inventory-I (STAI-I) anksiyete ölçeği uygulandı. Her iki grupta, peroperatif hemodinamik parametreler, VAS ile postoperatif ağrı düzeyleri, morfin tüketimleri ve gelişen yan etkiler kaydedilerek analiz edildi. Bulgular: Tüm hastalar demografik veriler yönünden karşılaştırıldığında gruplararası anlamlı bir fark görülmedi. Pregabalin ve Kontrol grubunda, premedikasyonda ilaç verilmeden önceki ve sonraki STAI-I puanları yönünden gruplararası farklılık anlamlı bulundu. İntraoperatif 30., 45., 75. ve postoperatif 1. dakikadaki OAB (Ortalama Arteryal Basınç) Pregabalin grubunda daha düşük seyretti. Postoperatif VAS (Vizüel Analog Skala) değerleri Pregabalin grubunda daha düşük bulundu. Ek analjezik kullanımı ve morfin tüketimleri 30 dakikadan sonra Pregabalin grubunda daha düşüktü. Her iki grup, yan etki yönünden incelendiğinde Kontrol grubunda %29 yan etki izlenirken, Pregabalin grubunda %10 olarak izlendi. Sonuç: Genel anestezi altında abdominal histerektomi geçirecek hastalarda, operasyondan 12 saat ve 1 saat önce uygulanan 150 mg pregabalinin preoperatif anksiyete skorlarını azalttığı, postoperatif analjezi sağladığı ve analjezik tüketimini azaltarak buna bağlı yan etkileri de azaltması nedeniyle plaseboya üstün olduğu, ancak pregabalinin rutin premedikasyona kazandırılabilmesi için farklı dozlar ve geniş örneklem grupları ile çalışmaların yapılması gerektiği sonucuna varıldı.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | BORA POLAT S, ÖZDEMİR KOL İ, Avcı O, İSBİR A, KAYGUSUZ K, GÜRSOY S (2019). Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. , 9 - 18. 10.5336/medsci.2018-62181 |
| Chicago | BORA POLAT Selma,ÖZDEMİR KOL İclal,Avcı Onur,İSBİR Ahmet Cemil,KAYGUSUZ KENAN,GÜRSOY Sinan Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. (2019): 9 - 18. 10.5336/medsci.2018-62181 |
| MLA | BORA POLAT Selma,ÖZDEMİR KOL İclal,Avcı Onur,İSBİR Ahmet Cemil,KAYGUSUZ KENAN,GÜRSOY Sinan Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. , 2019, ss.9 - 18. 10.5336/medsci.2018-62181 |
| AMA | BORA POLAT S,ÖZDEMİR KOL İ,Avcı O,İSBİR A,KAYGUSUZ K,GÜRSOY S Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. . 2019; 9 - 18. 10.5336/medsci.2018-62181 |
| Vancouver | BORA POLAT S,ÖZDEMİR KOL İ,Avcı O,İSBİR A,KAYGUSUZ K,GÜRSOY S Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. . 2019; 9 - 18. 10.5336/medsci.2018-62181 |
| IEEE | BORA POLAT S,ÖZDEMİR KOL İ,Avcı O,İSBİR A,KAYGUSUZ K,GÜRSOY S "Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication." , ss.9 - 18, 2019. 10.5336/medsci.2018-62181 |
| ISNAD | BORA POLAT, Selma vd. "Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication". (2019), 9-18. https://doi.org/10.5336/medsci.2018-62181 |
| APA | BORA POLAT S, ÖZDEMİR KOL İ, Avcı O, İSBİR A, KAYGUSUZ K, GÜRSOY S (2019). Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. Türkiye Klinikleri Tıp Bilimleri Dergisi, 39(1), 9 - 18. 10.5336/medsci.2018-62181 |
| Chicago | BORA POLAT Selma,ÖZDEMİR KOL İclal,Avcı Onur,İSBİR Ahmet Cemil,KAYGUSUZ KENAN,GÜRSOY Sinan Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. Türkiye Klinikleri Tıp Bilimleri Dergisi 39, no.1 (2019): 9 - 18. 10.5336/medsci.2018-62181 |
| MLA | BORA POLAT Selma,ÖZDEMİR KOL İclal,Avcı Onur,İSBİR Ahmet Cemil,KAYGUSUZ KENAN,GÜRSOY Sinan Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. Türkiye Klinikleri Tıp Bilimleri Dergisi, vol.39, no.1, 2019, ss.9 - 18. 10.5336/medsci.2018-62181 |
| AMA | BORA POLAT S,ÖZDEMİR KOL İ,Avcı O,İSBİR A,KAYGUSUZ K,GÜRSOY S Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2019; 39(1): 9 - 18. 10.5336/medsci.2018-62181 |
| Vancouver | BORA POLAT S,ÖZDEMİR KOL İ,Avcı O,İSBİR A,KAYGUSUZ K,GÜRSOY S Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2019; 39(1): 9 - 18. 10.5336/medsci.2018-62181 |
| IEEE | BORA POLAT S,ÖZDEMİR KOL İ,Avcı O,İSBİR A,KAYGUSUZ K,GÜRSOY S "Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication." Türkiye Klinikleri Tıp Bilimleri Dergisi, 39, ss.9 - 18, 2019. 10.5336/medsci.2018-62181 |
| ISNAD | BORA POLAT, Selma vd. "Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication". Türkiye Klinikleri Tıp Bilimleri Dergisi 39/1 (2019), 9-18. https://doi.org/10.5336/medsci.2018-62181 |
