Cofilin-1 as a potential biomarker to evaluate acute kidney injury

Abstract: Acute kidney injury (AKI) is a worldwide health problem and defined by rapid loss of excretory function of the kidney with the accumulation of metabolic end products. For effective treatment and prevent complications the early diagnosis of AKI is crucial. The current analytes used to diagnose AKI are not adequately sensitive and specific and therefore clinicians need new biomarkers. One of the new promising biomarker candidates of renal injury is cofilin-1. Previously, in our laboratory we isolated cofilin-1 in kidney preservation solution prior to transplantation and attempted to measure serum cofilin-1 in renal transplanted patients. However, cofilin-1 was not accurately measured in serum samples due to the methodological issues. In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.

Anahtar Kelime:

Akut böbrek hasarının değerlendirilmesinde potansiyel biyobelirteç olan Cofilin-1’in incelenmesi

Öz:

Akut böbrek hasarı dünya genelinde yaygın görülen bir sağlık sorunudur ve metabolik son ürünlerin birikimi ile böbreğin boşaltım işlevini hızlı bir şekilde kaybetmesiyle nitelendirilmektedir. Etkin tedavi ve komplikasyonları önlemek için akut böbrek hasarının erken teşhisi önemlidir. Akut böbrek hasarını teşhis etmek için kullanılan mevcut analitler yeterince hassas ve özgün değildir. Bu nedenle klinisyenlerin yeni biyobelirteçlere ihtiyacı vardır. Böbrek hasarı için umut veren yeni biyobelirteç adaylarından biri cofilin-1’dir. Daha önce laboratuvarımızda, transplantasyon öncesi böbrek koruma solüsyonunda cofilin-1 proteinini izole ettik ve böbrek nakli yapılan hastalarda serum cofilin-1 proteinini ölçmeye çalıştık. Ancak, serum örneklerinde cofilin-1 proteini metodolojik problemlerden dolayı doğru olarak ölçülmedi. Bu mini derlemede, akut böbrek hasarının teşhisi ve tedavisi için cofilin-1 ile ilgili hem literatür bilgisini hem de kendi deneyimlerimizi özetledik.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	COŞKUN A, UÇAL Y, Berber i, ÇAKIR Ü, Serteser M, MOLDUR D, İZZETE DERELİOĞLU E, Yozgatli T, ÖZPINAR A, ÜNSAL İ (2019). Cofilin-1 as a potential biomarker to evaluate acute kidney injury. , 9 - 15. 10.1515/tjb-2018-0287
Chicago	COŞKUN Abdurrahman,UÇAL Yasemin,Berber ibrahim,ÇAKIR Ülkem,Serteser Mustafa,MOLDUR Derya emel,İZZETE DERELİOĞLU Ecenur,Yozgatli Tahir Koray,ÖZPINAR AYSEL,ÜNSAL İbrahim Cofilin-1 as a potential biomarker to evaluate acute kidney injury. (2019): 9 - 15. 10.1515/tjb-2018-0287
MLA	COŞKUN Abdurrahman,UÇAL Yasemin,Berber ibrahim,ÇAKIR Ülkem,Serteser Mustafa,MOLDUR Derya emel,İZZETE DERELİOĞLU Ecenur,Yozgatli Tahir Koray,ÖZPINAR AYSEL,ÜNSAL İbrahim Cofilin-1 as a potential biomarker to evaluate acute kidney injury. , 2019, ss.9 - 15. 10.1515/tjb-2018-0287
AMA	COŞKUN A,UÇAL Y,Berber i,ÇAKIR Ü,Serteser M,MOLDUR D,İZZETE DERELİOĞLU E,Yozgatli T,ÖZPINAR A,ÜNSAL İ Cofilin-1 as a potential biomarker to evaluate acute kidney injury. . 2019; 9 - 15. 10.1515/tjb-2018-0287
Vancouver	COŞKUN A,UÇAL Y,Berber i,ÇAKIR Ü,Serteser M,MOLDUR D,İZZETE DERELİOĞLU E,Yozgatli T,ÖZPINAR A,ÜNSAL İ Cofilin-1 as a potential biomarker to evaluate acute kidney injury. . 2019; 9 - 15. 10.1515/tjb-2018-0287
IEEE	COŞKUN A,UÇAL Y,Berber i,ÇAKIR Ü,Serteser M,MOLDUR D,İZZETE DERELİOĞLU E,Yozgatli T,ÖZPINAR A,ÜNSAL İ "Cofilin-1 as a potential biomarker to evaluate acute kidney injury." , ss.9 - 15, 2019. 10.1515/tjb-2018-0287
ISNAD	COŞKUN, Abdurrahman vd. "Cofilin-1 as a potential biomarker to evaluate acute kidney injury". (2019), 9-15. https://doi.org/10.1515/tjb-2018-0287

APA	COŞKUN A, UÇAL Y, Berber i, ÇAKIR Ü, Serteser M, MOLDUR D, İZZETE DERELİOĞLU E, Yozgatli T, ÖZPINAR A, ÜNSAL İ (2019). Cofilin-1 as a potential biomarker to evaluate acute kidney injury. Türk Biyokimya Dergisi, 44(1), 9 - 15. 10.1515/tjb-2018-0287
Chicago	COŞKUN Abdurrahman,UÇAL Yasemin,Berber ibrahim,ÇAKIR Ülkem,Serteser Mustafa,MOLDUR Derya emel,İZZETE DERELİOĞLU Ecenur,Yozgatli Tahir Koray,ÖZPINAR AYSEL,ÜNSAL İbrahim Cofilin-1 as a potential biomarker to evaluate acute kidney injury. Türk Biyokimya Dergisi 44, no.1 (2019): 9 - 15. 10.1515/tjb-2018-0287
MLA	COŞKUN Abdurrahman,UÇAL Yasemin,Berber ibrahim,ÇAKIR Ülkem,Serteser Mustafa,MOLDUR Derya emel,İZZETE DERELİOĞLU Ecenur,Yozgatli Tahir Koray,ÖZPINAR AYSEL,ÜNSAL İbrahim Cofilin-1 as a potential biomarker to evaluate acute kidney injury. Türk Biyokimya Dergisi, vol.44, no.1, 2019, ss.9 - 15. 10.1515/tjb-2018-0287
AMA	COŞKUN A,UÇAL Y,Berber i,ÇAKIR Ü,Serteser M,MOLDUR D,İZZETE DERELİOĞLU E,Yozgatli T,ÖZPINAR A,ÜNSAL İ Cofilin-1 as a potential biomarker to evaluate acute kidney injury. Türk Biyokimya Dergisi. 2019; 44(1): 9 - 15. 10.1515/tjb-2018-0287
Vancouver	COŞKUN A,UÇAL Y,Berber i,ÇAKIR Ü,Serteser M,MOLDUR D,İZZETE DERELİOĞLU E,Yozgatli T,ÖZPINAR A,ÜNSAL İ Cofilin-1 as a potential biomarker to evaluate acute kidney injury. Türk Biyokimya Dergisi. 2019; 44(1): 9 - 15. 10.1515/tjb-2018-0287
IEEE	COŞKUN A,UÇAL Y,Berber i,ÇAKIR Ü,Serteser M,MOLDUR D,İZZETE DERELİOĞLU E,Yozgatli T,ÖZPINAR A,ÜNSAL İ "Cofilin-1 as a potential biomarker to evaluate acute kidney injury." Türk Biyokimya Dergisi, 44, ss.9 - 15, 2019. 10.1515/tjb-2018-0287
ISNAD	COŞKUN, Abdurrahman vd. "Cofilin-1 as a potential biomarker to evaluate acute kidney injury". Türk Biyokimya Dergisi 44/1 (2019), 9-15. https://doi.org/10.1515/tjb-2018-0287