Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts

Topcu, Gulacti; HALFON, Belkıs; KÖKDİL, Gamze; ÇETİN, ÖZLEM

doi:10.25135/rnp.99.18.05.291

Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts

Belkıs Halfon, (Boğaziçi Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Özlem Çetin, (Boğaziçi Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Gamze Kökdil, (Mersin Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Mersin, Türkiye)

Gülaçtı Topçu (Bezmialem Vakıf Üniversitesi, Eczacılık Fakültesi, Farmakognozi ve Fitokimya Anabilim Dalı, İstanbul, Türkiye)

Records of Natural Products

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Yıl: 2019 Cilt: 13 Sayı: 2 Sayfa Aralığı: 156 - 166 Metin Dili: İngilizce DOI: 10.25135/rnp.99.18.05.291 İndeks Tarihi: 24-06-2020

Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts

Öz:

In this study the antioxidant and anticholinesterase activities of the crude ethanol extract, as well asthe dichloromethane and water extracts obtained from partitioning of the crude ethanol extract, of the plantSalvia cassia Samuelss ex. Rech. Fil, were determined. The extracts were screened for their total phenolic andflavonoid contents. The dichloromethane extract, which showed higher inhibition of lipid peroxidation, highermetal chelating capacity and also a higher flavonoid content than the other extracts was analyzed for itsconstituents. GC-MS analysis resulted in the identification of a total of 30 long chain hydrocarbons. A series of-amyrin fatty acid esters, a triterpene acid oleanolic acid, a diterpenoid manoyloxide, and two flavonoidsapigenin 7, 4′-dimethyl ether and salvigenin were isolated by open column chromatography. Their structureswere identified based on NMR and mass spectrometric techniques. The isolated compounds were also tested fortheir anticholinesterase activities. The triterpenoids as well as the water extract exhibited promisinganticholinesterase activity.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	HALFON B, ÇETİN Ö, KÖKDİL G, Topcu G (2019). Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. , 156 - 166. 10.25135/rnp.99.18.05.291
Chicago	HALFON Belkıs,ÇETİN ÖZLEM,KÖKDİL Gamze,Topcu Gulacti Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. (2019): 156 - 166. 10.25135/rnp.99.18.05.291
MLA	HALFON Belkıs,ÇETİN ÖZLEM,KÖKDİL Gamze,Topcu Gulacti Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. , 2019, ss.156 - 166. 10.25135/rnp.99.18.05.291
AMA	HALFON B,ÇETİN Ö,KÖKDİL G,Topcu G Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. . 2019; 156 - 166. 10.25135/rnp.99.18.05.291
Vancouver	HALFON B,ÇETİN Ö,KÖKDİL G,Topcu G Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. . 2019; 156 - 166. 10.25135/rnp.99.18.05.291
IEEE	HALFON B,ÇETİN Ö,KÖKDİL G,Topcu G "Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts." , ss.156 - 166, 2019. 10.25135/rnp.99.18.05.291
ISNAD	HALFON, Belkıs vd. "Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts". (2019), 156-166. https://doi.org/10.25135/rnp.99.18.05.291

APA	HALFON B, ÇETİN Ö, KÖKDİL G, Topcu G (2019). Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. Records of Natural Products, 13(2), 156 - 166. 10.25135/rnp.99.18.05.291
Chicago	HALFON Belkıs,ÇETİN ÖZLEM,KÖKDİL Gamze,Topcu Gulacti Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. Records of Natural Products 13, no.2 (2019): 156 - 166. 10.25135/rnp.99.18.05.291
MLA	HALFON Belkıs,ÇETİN ÖZLEM,KÖKDİL Gamze,Topcu Gulacti Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. Records of Natural Products, vol.13, no.2, 2019, ss.156 - 166. 10.25135/rnp.99.18.05.291
AMA	HALFON B,ÇETİN Ö,KÖKDİL G,Topcu G Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. Records of Natural Products. 2019; 13(2): 156 - 166. 10.25135/rnp.99.18.05.291
Vancouver	HALFON B,ÇETİN Ö,KÖKDİL G,Topcu G Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts. Records of Natural Products. 2019; 13(2): 156 - 166. 10.25135/rnp.99.18.05.291
IEEE	HALFON B,ÇETİN Ö,KÖKDİL G,Topcu G "Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts." Records of Natural Products, 13, ss.156 - 166, 2019. 10.25135/rnp.99.18.05.291
ISNAD	HALFON, Belkıs vd. "Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts". Records of Natural Products 13/2 (2019), 156-166. https://doi.org/10.25135/rnp.99.18.05.291