Clinical evaluation of dental enamel defects and oral findings in coeliac children

Damla Akşit Bıçak, (Yakın Doğu Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Anabilim Dalı, Kuzey Kıbrıs Türk Cumhuriyet)
Nafiye Urgancı, (Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Pediatrik Gastroenteroloji Kliniği, İstanbul, Türkiye)
Serap Akyüz, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Anabilim Dalı, İstanbul, Türkiye)
Merve Usta, (Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Pediatrik Gastroenteroloji Kliniği, İstanbul, Türkiye)
Nuray Uslu Kızılkan, (Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Pediatrik Gastroenteroloji Kliniği, İstanbul, Türkiye)
Burçin Alev, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Biyokimya Temel Bilimleri Bölümü, İstanbul, Türkiye)
Ayşen Yarat (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Biyokimya Temel Bilimleri Bölümü, İstanbul, Türkiye)
European oral research (Online)
3 0
Yıl: 2018 Cilt: 52 Sayı: 3 Sayfa Aralığı: 150 - 156 Metin Dili: İngilizce DOI: 10.26650/eor.2018.525 İndeks Tarihi: 30-06-2020

Clinical evaluation of dental enamel defects and oral findings in coeliac children

Öz:
To examine dental hard and soft tissue changes of coeliac children in order toincrease the awareness of the pediatric dentists in prediagnosis of especiallyundiagnosed coeliac disease.Materials and methodsSixty children, 28 (46.7%) boys and 32 (53.3%) girls whose ages were between 6 to16 years were included in the present study. Thirty children who had undergoneendoscopy and diagnosed with the coeliac disease in the Şişli Hamidiye EtfalHospital, İstanbul, Turkey, formed the study group. Also, thirty children clinicallysuspected of having the coeliac disease with the same gastrointestinal complaintshad undergone endoscopy and proven not coeliac were chosen as the control group.Oral examination involved assessment of dentition and specific and unspecificdental enamel defects. Also, soft tissue lesions, clinical delay of the dental eruption,salivary flow rate, pH, and buffering capacity were examined.ResultsTwenty coeliac patients had enamel defects, however none in the control subjects.In the coeliac group, all enamel defects were diagnosed in permanent teeth and asspecific in all children. Grade I dental enamel defects found mainly in the incisors.The clinical delayed eruption was observed in 10 (33.3%) of 30 coeliac children andnone of the children in the control group. While the level of DMFT/S numbers andstimulated salivary flow rate were found significantly lower in the coeliac group, pHwas found significantly higher.ConclusionOral cavity may be involved in coeliac disease and pediatric dentists can play animportant role in the early diagnosis of the coeliac disease.
Anahtar Kelime:

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Öz:
Çölyak hastalığı olan çocuklarda diş mine defektlerinin ve oral bulguların değerlendirilmesi. Amaç: Çölyak hastalığı olan çocukların diş sert ve yumuşak doku değişikliklerini inceleyerek özellikle tanı konulmamış çölyak hastalığının ön tanısında çocuk diş hekimlerinin farkındalığını arttırmaktır. Gereç ve Yöntem: Çalışmaya yaşları 6-16 arasında değişen, 28 (%46,7) erkek ve 32 (%53,3) kız toplam 60 çocuk dâhil edilmiştir. Çalışma grubunu, Şişli Hamidiye Etfal Hastanesi, gastroenteroloji bölümüne başvuran ve endoskopi sonucuna göre çölyak hastalığı teşhisi konulmuş 30 çocuk oluşturmuştur. Kontrol grubunu ise klinik olarak aynı gastrointestinal şikayetlere sahip olan, çölyak hastalığından şüphelenilenerek endoskopi yapılmış ve çölyak hastalığı olmadığı kanıtlanmış 30 çocuk oluşturmuştur. Ağız içi muayenede, dişlenme dönemi, spesifik ve spesifik olmayan diş mine defektleri değerlendirilmiştir. Ayrıca, yumuşak doku lezyonları, diş sürme gecikmesi varlığı, tükürük akış hızı, pH ve tamponlama kapasitesi değerleri incelenmiştir. Bulgular: Yirmi çölyak hastası çocukta diş mine defekti saptanırken, kontrol grubunda saptanmamıştır. Çölyak grubunda tüm diş mine defektleri spesifik tipte ve daimi dişlerde tespit edilmiştir. Birinci derecede olan diş mine defektleri çoğunlukla kesici dişlerde görülmüştür. Sürme gecikmesi 30 çölyak hastası çocuğunun 10'unda (%33,3) gözlenmiş ve kontrol grubundaki hiçbir çocukta gözlenmemiştir. Çölyak grubunda DMFT/S değerleri ve uyarılmış tükürük akış hızı düzeyleri kontrol grubundan anlamlı olarak daha düşük, pH değeri anlamlı olarak daha yüksek bulunmuştur. Sonuç: Çölyak hastalığında ağız boşluğu etkilenebilir ve çocuk diş hekimleri bu hastalığın ön tanısında önemli bir rol oynayabilir. Anahtar kelimeler: Çürük; çölyak hastalığı; diş mine defekti; diş sürmesi; tekrarlayan aftöz stomatit.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Küçükazman M, Ata N, Dal K, Nazlıgül Y. Çölyak hastalığı. Dirim Tıp Derg 2008; 83: 55-92.
  • 2. Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M, Ribes-Koninckx C, Ventura A, Zimmer KP; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136-60. [CrossRef]
  • 3. Cataldo F, Montalto G. Celiac disease in the developing countries. A new and challenging public health problem. World J Gastroenterol 2007; 13: 2153-9. [CrossRef]
  • 4. Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L. Oral manifestations of coeliac disease. J Clin Gastroenterol 2008; 42: 224-32.
  • 5. Campisi G, Di Liberto C, Iacono G, Compilato D, Di Prima L, Calvino F, Di Marco V, Lo Muzio L, Sferrazza C, Scalici C, Craxì A, Carroccio A. Oral pathology in untreated coeliac disease. Aliment Pharmacol Ther 2007; 26: 1529-36. [CrossRef]
  • 6. Procaccini M, Campisi G, Bufo P, Compilato D, Massaccesi C, Catassi C, Lo Muzio L. Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from İtalian central region. Head Face Med 2007; 3: 25. [CrossRef]
  • 7. Aine L, Maki M, Keyriläinen O, and Collin P. Dental enamel defects in Celiac disease. J Oral Path Med 1990; 19: 241-5. [CrossRef]
  • 8. Maki M, Aine L, Lipsanen V, Koskimies S. Dental enamel defects in first-degree relatives of coeliac disease patients. Lancet 199; 337: 763-4. [CrossRef]
  • 9. Maki M, Sulkanen S, Collin P. Antibodies in relation to gluten intake. Digest Dis 1998; 16: 330-2. [CrossRef]
  • 10. Seow W.K. Enamel hypoplasia in the primary dentition: a review. ASDC J Dent Child 1991; 58: 441-52.
  • 11. Abenavoli L, Proietti I, Leggio L, Ferrulli A, Vonghia L, Capizzi R, Rotoli M, Amerio PL, Gasbarrini G, Addolorato G. Cutaneous manifestations in Celiac disease. World J Gastroenterol 2006; 12: 843-52. [CrossRef]
  • 12. Wierink CD, Van Dierman DE, Aartman IH, Heymans HS. Dental enamel defects in children with coeliac disease. Int J Paediatr Dent 2007; 17: 163-8. [CrossRef]
  • 13. Lähteenoja H, Toivanen A, Viander M, Mäki M, Irjala K, Räihä I, Syrjänen S. Oral mucosal changes in coeliac patients on a gluten-free diet. Eur J Oral Sci 1998; 106: 899-906. [CrossRef]
  • 14. Bramanti E, Cicciu M, Matacena G, Costa S, Magazzu G. Clinical Evaluation of specific oral manifestations in pediatric patients with ascertained versus potential coeliac disease: A cross-sectional study. Gastroenterol Res Pract 2014; 2014: doi: 10.1155/2014/934159. [CrossRef]
  • 15. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990; 65: 909-11. [CrossRef]
  • 16. Costacurta M, Maturo P, Bartolino M, Docimo R. Oral manifestations of coeliac disease. A clinical-statistic srudy. Oral Implantol (Rome) 2010; 1: 12-9.
  • 17. Avşar A, Kalaycı AG. The presence and distribution of dental enamel defects and caries in children with celiac disease. Turk J Pediatr 2008; 50: 45-50.
  • 18. Rashid M, Zarkadas M, Anca A, Limeback H. Oral manifestations of celiac disease: A clinical guide for dentists. J Can Assoc 2011; 77: 39-44.
  • 19. Ortega Páez E, Junco Lafuente P, Baca García P, Maldonado Lozano J, Llodra Calvo JC. Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 74-8. [CrossRef]
  • 20. Aine L. Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc 1986; 82: 1-7.
  • 21. World Health Organization. Oral health surveys: basic methods 4th edn. Geneva: WHO; 1997.
  • 22. Erriu M, Canargiu F, Orru G, Garau V, Montaldo C. Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. J Med Case Rep 2012; 6: 185. [CrossRef]
  • 23. Cigic L, Galic T, Kero D, Simunic M, Mikic IM, Govorko DK, Lukenda DB. The prevalence of celiac disease in patients with geographic tongue. J Oral Pathol Med 2016; 45: 791-6. [CrossRef]
  • 24. Ertekin V, Sümbüllü MA, Tosun MS, Selimoğlu MA, Kara M, Kılıç N. Oral findings in children with celiac disease. Turk J Med Sci 2012; 42: 613-7.
  • 25. Mina S, Azcurra AI, Riga C, Cornejo LS, Brunotto M. Evaluation of clinical dental variables to build classifiers to predict celiac disease. Med Oral Patol Oral Cir Bucal 2008; 13: 398-402.
  • 26. Campisi G, Di Liberto C, Carroccio A, Compilato D, Iacono G, Procaccini M, Di Fede G, Lo Muzio L, Craxi A, Catassi C, Scully C. Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Dig Liver Dis 2008; 40: 104-7. [CrossRef]
  • 27. Koç Öztürk L, A Yarat, Akyuz S, Furuncuoglu H, Ulucan K. Investigation of the N-terminal coding region of MUC7 alterations in dentistry students with and without caries. Balkan J Med Genet 2016; 19: 71-6. [CrossRef]
  • 28. Da Silva PC, de Almeida P del V, Machado MA, de Lima AA, Grégio AM, Trevilatto PC, Azevedo-Alanis LR. Oral manifestations of celiac disease. A case report and review of the literature. Med Oral Patol Oral Cir Bucal 2008; 13: 559-62.
  • 29. Holmes GKT, Prior P, Lane MR, Pope D, Allan RN. Malignancy in coeliac disease: effect of a gluten free diet. Gut 1989; 30: 333-8. [CrossRef]
  • 30. Aquirre JM, Rotriguez R, Oribe D, Vitoria JC. Dental enamel defects in celiac patients. Oral Surg Oral Med Oral Path Oral Radiol Endod 1997; 84: 646-50. [CrossRef]
  • 31. Acar S, Aykut Yetkiner A, Ersin N, Oncag O, Aydogdu S, Arıkan C. Oral findings and salivary parameters in children with celiac disease: A preliminary study. Med Princ Pract 2012; 21: 129-33. [CrossRef]
  • 32. Farmakis E, Puntis JW, Toumba
  • 18. Rashid M, Zarkadas M, Anca A, Limeback H. Oral manifestations of celiac disease: A clinical guide for dentists. J Can Assoc 2011; 77: 39-44.
  • 19. Ortega Páez E, Junco Lafuente P, Baca García P, Maldonado Lozano J, Llodra Calvo JC. Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 74-8. [CrossRef]
  • 20. Aine L. Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc 1986; 82: 1-7.
  • 21. World Health Organization. Oral health surveys: basic methods 4th edn. Geneva: WHO; 1997.
  • 22. Erriu M, Canargiu F, Orru G, Garau V, Montaldo C. Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. J Med Case Rep 2012; 6: 185. [CrossRef]
  • 23. Cigic L, Galic T, Kero D, Simunic M, Mikic IM, Govorko DK, Lukenda DB. The prevalence of celiac disease in patients with geographic tongue. J Oral Pathol Med 2016; 45: 791-6. [CrossRef]
  • 24. Ertekin V, Sümbüllü MA, Tosun MS, Selimoğlu MA, Kara M, Kılıç N. Oral findings in children with celiac disease. Turk J Med Sci 2012; 42: 613-7.
  • 25. Mina S, Azcurra AI, Riga C, Cornejo LS, Brunotto M. Evaluation of clinical dental variables to build classifiers to predict celiac disease. Med Oral Patol Oral Cir Bucal 2008; 13: 398-402.
  • 26. Campisi G, Di Liberto C, Carroccio A, Compilato D, Iacono G, Procaccini M, Di Fede G, Lo Muzio L, Craxi A, Catassi C, Scully C. Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Dig Liver Dis 2008; 40: 104-7. [CrossRef]
  • 27. Koç Öztürk L, A Yarat, Akyuz S, Furuncuoglu H, Ulucan K. Investigation of the N-terminal coding region of MUC7 alterations in dentistry students with and without caries. Balkan J Med Genet 2016; 19: 71-6. [CrossRef]
  • 28. Da Silva PC, de Almeida P del V, Machado MA, de Lima AA, Grégio AM, Trevilatto PC, Azevedo-Alanis LR. Oral manifestations of celiac disease. A case report and review of the literature. Med Oral Patol Oral Cir Bucal 2008; 13: 559-62.
  • 29. Holmes GKT, Prior P, Lane MR, Pope D, Allan RN. Malignancy in coeliac disease: effect of a gluten free diet. Gut 1989; 30: 333-8. [CrossRef]
  • 30. Aquirre JM, Rotriguez R, Oribe D, Vitoria JC. Dental enamel defects in celiac patients. Oral Surg Oral Med Oral Path Oral Radiol Endod 1997; 84: 646-50. [CrossRef]
  • 31. Acar S, Aykut Yetkiner A, Ersin N, Oncag O, Aydogdu S, Arıkan C. Oral findings and salivary parameters in children with celiac disease: A preliminary study. Med Princ Pract 2012; 21: 129-33. [CrossRef]
  • 32. Farmakis E, Puntis JW, Toumba KJ. Enamel defects in children with coeliac disease. Eur J Paediatr Dent 2005; 6: 129-32.
  • 33. Priovolou CH, Vanderas AP, Papagiannoulis L. A comperative study on the prevalence of enamel defects and dental caries in children and adolescents with and without coeliac disease. Eur J Paediatr Dent 2004; 5: 102-6.
  • 34. Cantekin K, Arslan D, Delikan E. Presence and distribution of dental enamel defects, recurrent aphtous lesions and dental caries in children with celiac disease. Pak J Med Sci 2015; 31: 606-9.
  • 35. Ouda S, Saadah O, El Meligy O, Alaki S. Genetic and dental study of patients with celiac disease. J Clin Pediatric Dent 2010; 35: 217- 24. [CrossRef]
  • 36. Shteyer E, Berson T, Lachmanovitz O, Hidas A, Wilschanski M, Menachem M, Shachar E, Shapira J, Steinberg D, Moskovitz M. Oral health status and salivary properties in relation to gluten-free diet in children with celiac disease. J Pediatr Gastroenterol Nutr 2013; 57: 49-52. [CrossRef]
  • 37. Rasmusson CG, Eriksson MA. Celiac diasese and mineralisation disturbances of permanent teeth. Int J Paediatr Dent 2001; 11: 179-83. [CrossRef]
  • 38. Cheng J, Malahias T, Brar P, Minaya MT, Green PH. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States Cohort. J Clin Gastroenterol 2010; 44: 191- 4. [CrossRef]
  • 39. Aine L. Coeliac-type permanent-tooth enamel defects. Ann Med 1996; 28: 9-12. [CrossRef]
  • 40. Sedghizadeh P, Schuler CF, Allen CM, Beck FM, Kalmar JR. Celiac disease and recurrent aphtous stomatitis: A report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 474-8. [CrossRef]
  • 41. Yaşar Ş, Yaşar B, Abut E, Aşıran Serdar Z. Clinical importance of celiac disease in patients with recurrent aphthous stomatitis. Turk J Gastroenterol 2012; 23: 14-8. [CrossRef]
  • 42. Collin P, Reunala T, Pukkala E, Laippala P, Keyriläinen O, Pasternack A. Coeliac disease--associated disorders and survival. Gut 1994; 35: 1215-8. [CrossRef]
  • 43. Lenander-Lumikari, Ihalin R, Lähteenoja H. Changes in whole saliva in patients with coeliac disease. Arch Oral Biol 2000; 45: 347-54. [CrossRef]
  • 44. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001; 120: 636-51. [CrossRef]
  • 45. Mariani P, Mazzilli MC, Margutti G, Lionetti P, Triglione P, Petronzelli F, Ferrante E, Bonamico M. Coeliac disease, enamel defects and HLA typing. Acta Paediatr 1994; 83: 1272-5. [CrossRef]
APA Aksit-Bicak D, URGANCI N, Akyuz S, USTA M, Uslu Kızılkan N, Alev-Tuzuner B, Yarat A (2018). Clinical evaluation of dental enamel defects and oral findings in coeliac children. , 150 - 156. 10.26650/eor.2018.525
Chicago Aksit-Bicak Damla,URGANCI Nafiye,Akyuz Serap,USTA Merve,Uslu Kızılkan Nuray,Alev-Tuzuner Burcin,Yarat Aysen Clinical evaluation of dental enamel defects and oral findings in coeliac children. (2018): 150 - 156. 10.26650/eor.2018.525
MLA Aksit-Bicak Damla,URGANCI Nafiye,Akyuz Serap,USTA Merve,Uslu Kızılkan Nuray,Alev-Tuzuner Burcin,Yarat Aysen Clinical evaluation of dental enamel defects and oral findings in coeliac children. , 2018, ss.150 - 156. 10.26650/eor.2018.525
AMA Aksit-Bicak D,URGANCI N,Akyuz S,USTA M,Uslu Kızılkan N,Alev-Tuzuner B,Yarat A Clinical evaluation of dental enamel defects and oral findings in coeliac children. . 2018; 150 - 156. 10.26650/eor.2018.525
Vancouver Aksit-Bicak D,URGANCI N,Akyuz S,USTA M,Uslu Kızılkan N,Alev-Tuzuner B,Yarat A Clinical evaluation of dental enamel defects and oral findings in coeliac children. . 2018; 150 - 156. 10.26650/eor.2018.525
IEEE Aksit-Bicak D,URGANCI N,Akyuz S,USTA M,Uslu Kızılkan N,Alev-Tuzuner B,Yarat A "Clinical evaluation of dental enamel defects and oral findings in coeliac children." , ss.150 - 156, 2018. 10.26650/eor.2018.525
ISNAD Aksit-Bicak, Damla vd. "Clinical evaluation of dental enamel defects and oral findings in coeliac children". (2018), 150-156. https://doi.org/10.26650/eor.2018.525
APA Aksit-Bicak D, URGANCI N, Akyuz S, USTA M, Uslu Kızılkan N, Alev-Tuzuner B, Yarat A (2018). Clinical evaluation of dental enamel defects and oral findings in coeliac children. European oral research (Online), 52(3), 150 - 156. 10.26650/eor.2018.525
Chicago Aksit-Bicak Damla,URGANCI Nafiye,Akyuz Serap,USTA Merve,Uslu Kızılkan Nuray,Alev-Tuzuner Burcin,Yarat Aysen Clinical evaluation of dental enamel defects and oral findings in coeliac children. European oral research (Online) 52, no.3 (2018): 150 - 156. 10.26650/eor.2018.525
MLA Aksit-Bicak Damla,URGANCI Nafiye,Akyuz Serap,USTA Merve,Uslu Kızılkan Nuray,Alev-Tuzuner Burcin,Yarat Aysen Clinical evaluation of dental enamel defects and oral findings in coeliac children. European oral research (Online), vol.52, no.3, 2018, ss.150 - 156. 10.26650/eor.2018.525
AMA Aksit-Bicak D,URGANCI N,Akyuz S,USTA M,Uslu Kızılkan N,Alev-Tuzuner B,Yarat A Clinical evaluation of dental enamel defects and oral findings in coeliac children. European oral research (Online). 2018; 52(3): 150 - 156. 10.26650/eor.2018.525
Vancouver Aksit-Bicak D,URGANCI N,Akyuz S,USTA M,Uslu Kızılkan N,Alev-Tuzuner B,Yarat A Clinical evaluation of dental enamel defects and oral findings in coeliac children. European oral research (Online). 2018; 52(3): 150 - 156. 10.26650/eor.2018.525
IEEE Aksit-Bicak D,URGANCI N,Akyuz S,USTA M,Uslu Kızılkan N,Alev-Tuzuner B,Yarat A "Clinical evaluation of dental enamel defects and oral findings in coeliac children." European oral research (Online), 52, ss.150 - 156, 2018. 10.26650/eor.2018.525
ISNAD Aksit-Bicak, Damla vd. "Clinical evaluation of dental enamel defects and oral findings in coeliac children". European oral research (Online) 52/3 (2018), 150-156. https://doi.org/10.26650/eor.2018.525
Sayfa Oluşturulma Tarihi
23-04-2024 12:29

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