Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers

Yıl: 2019 Cilt: 30 Sayı: 8 Sayfa Aralığı: 686 - 694 Metin Dili: İngilizce DOI: 10.5152/tjg.2019.17770 İndeks Tarihi: 20-07-2020

Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers

Öz:
Background/Aims: Patients with colorectal cancer continue to present with relatively advanced tumors that are associated with pooroncological outcomes. The aim of the present study was to assess the association between localization, symptom duration, and tumorstage.Materials and Methods: A prospective, multicenter cohort study was conducted on patients newly diagnosed with a histologically proven colorectal adenocarcinoma. Standardized questionnaire-interviews were performed. Data were collected on principal presentingsymptoms, duration of symptoms (time to first presentation to a doctor and time to diagnosis) and treatment, diagnostic procedures,tumor site, and stage of the tumor (tumor, node, and metastasis (TNM)).Results: A total of 1795 patients with colorectal cancer were interviewed (mean age: 60.76±13.50 years, male patients: 1057, patientsaged >50 years: 1444, colon/rectal cancer: 899/850, right side/left side: 383/1250, stage 0-1-2/stage 3-4: 746/923). No statisticallysignificant correlations were found between duration of symptoms and either tumor site or stage. Principal presenting symptoms weresignificantly associated with left colon cancer. Patients who had “anemia,” “change in bowel habits,” “anal pruritus or discharge,” “weightloss,” and “tumor in right colon” had a significantly longer symptom time.Conclusion: Symptom duration is not associated with localization, nor is the tumor stage. Diagnosis of colorectal cancer at an earlierstage may be best achieved by screening of the population.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Majumdar SR, Fletcher RH, Evans AT. How does colorectal cancer present? Symptoms, duration, and clues to location. Am J Gastroenterol 1999; 94: 3039-45. [CrossRef]
  • 2. Esteva M, Leiva A, Ramos M, et al. Factors related with symptom duration until diagnosis and treatment of symptomatic colorectal cancer. BMC Cancer 2013; 13: 87. [CrossRef]
  • 3. Jullumstrø E, Lydersen S, Møller B, Dahl O, Edna TH. Duration of symptoms, stage at diagnosis and relative survival in colon and rectal cancer. Eur J Cancer 2009; 45: 2383-90. [CrossRef]
  • 4. McDermott FT, Hughes ES, Pihl E, Milne BJ, Price AB. Prognosis in relation to symptom duration in colon cancer. Br J Surg 1981; 68: 846-9. [CrossRef]
  • 5. Olsson L, Bergkvist L, Ekbom A. Symptomdurationversussurvival in non-emergencycolorectalcancer. Scand J Gastroenterol 2004; 39: 252-8. [CrossRef]
  • 6. Gonzalez-Hermoso F, Perez-Palma J, Marchena-Gomez J, Lorenzo-Rocha N, Medina-Arana V. Can early diagnosis of symptomatic colorectal cancer improve the prognosis? World J Surg 2004; 28: 716-20. [CrossRef]
  • 7. Rupassara KS, Ponnusamy S, Withanage N, Milewski PJ. A paradox explained? Patients with delayed diagnosis of symptomatic colorectal cancer have good prognosis. Colorectal Dis 2006; 8: 423-9. [CrossRef]
  • 8. Ramos M, Esteva M, Cabeza E, Llobera J, Ruiz A. Lack of association between diagnostic and therapeutic delay and stage of colorectal cancer. Eur J Cancer 2008; 44: 510-21. [CrossRef]
  • 9. Ramos M, Esteva M, Cabeza E, Campillo C, Llobera J, Aguiló A. Relationship of diagnostic and therapeutic delay with survival in colorectal cancer: a review. Eur J Cancer 2007; 43: 2467-78. [CrossRef]
  • 10. Faul F, Erdfelder E, Lang AG, Buchner AG. Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175-91. [CrossRef]
  • 11. Colon and rectum. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors: AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2010.p 143-64. [CrossRef]
  • 12. Kelloff GJ, Schilsky RL, Alberts DS, et al. Colorectal adenomas: a prototype for the use of surrogate end points in the development of cancer prevention drugs. Clin Cancer Res 2004; 10: 3908-18. [CrossRef]
  • 13. Terhaar sive Droste JS, Oort FA, van der Hulst RW, et al. Does delay in diagnosing colorectal cancer in symptomatic patients affect tumor stage and survival? A population-based observational study. BMC Cancer 2010; 10: 332. [CrossRef]
  • 14. Pescatori M, Maria G, Beltrani B, Mattana C. Site, emergency, and duration of symptoms in the prognosis of colorectal cancer. Dis Colon Rectum 1982; 25: 33-40. [CrossRef]
  • 15. Robinson E, Mohilever J, Zidan J, Sapir D. Colorectal cancer: incidence, delay in diagnosis and stage of disease. Eur J Cancer Clin Oncol 1986; 22: 157-61. [CrossRef]
  • 16. Young CJ, Sweeney JL, Hunter A. Implications of delayed diagnosis in colorectal cancer. ANZ Surg 2000; 70: 635-8. [CrossRef]
  • 17. Thompson MR, Asiimwe A, Flashman K, Tsavellas G. Is earlier referral and investigation of bowel cancer patients presenting with rectal bleeding associated with better survival? Colorectal Dis 2011; 13: 1242-8. [CrossRef]
  • 18. Bharucha S, Hughes S, Kenyon V, Anderson ID, Carlson GL, Scott NA. Targets and elective colorectal cancer: outcome and symptom delay at surgical resection. Colorectal Dis 2005; 7: 169-71. [CrossRef]
  • 19. Mulcahy HE, O’Donoghue DP. Duration of colorectal cancer symptoms and survival: the effect of confounding clinical and pathological variables. Eur J Cancer 1997: 33; 1461-7. [CrossRef]
  • 20. Kyle SM, Isbister WH, Yeong ML. Presentation, duration of symptoms and staging of colorectal carcinoma. ANZ Surg 1991; 61: 137- 40. [CrossRef]
  • 21. Fleischer DE, Goldberg SB, Browning TH, et al. Detection and surveillance of colorectal cancer. JAMA 1989; 261: 580-5. [CrossRef]
  • 22. Suttie SA, Shaikh I, Mullen R, Amin AI, Daniel T, Yalamarthi S. Outcome of right- and left-sided colonic and rectal cancer following surgical resection. Colorectal Dis 2011; 13: 884-9. [CrossRef]
  • 23. Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N. Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol 2008; 15: 2388-94. [CrossRef]
APA Ozturk E, KUZU M, ÖZTUNA D, IŞIK Ö, CANDA A, BALIK E, ERKASAP S, YOLDAŞ T, Akyol C, Demirbas S, ÖZOĞUL B, TOPÇU Ö, GEDİK E, Baca B, ERGÜNER İ, ASOĞLU O, ERKEK B, Yılmazlar T, REİS E, GENÇOSMANOĞLU R, Aslar A, Konan A (2019). Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. , 686 - 694. 10.5152/tjg.2019.17770
Chicago Ozturk Ersin,KUZU Mehmet Ayhan,ÖZTUNA Derya,IŞIK Özgen,CANDA Aras Emre,BALIK Emre,ERKASAP Serdar,YOLDAŞ Tayfun,Akyol Cihangir,Demirbas Sezai,ÖZOĞUL Bünyamin,TOPÇU Ömer,GEDİK Ercan,Baca Bilgi,ERGÜNER İlknur,ASOĞLU Oktar,ERKEK Bülent,Yılmazlar Tuncay,REİS Erhan,GENÇOSMANOĞLU Rasim,Aslar Ahmet Kessaf,Konan Ali Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. (2019): 686 - 694. 10.5152/tjg.2019.17770
MLA Ozturk Ersin,KUZU Mehmet Ayhan,ÖZTUNA Derya,IŞIK Özgen,CANDA Aras Emre,BALIK Emre,ERKASAP Serdar,YOLDAŞ Tayfun,Akyol Cihangir,Demirbas Sezai,ÖZOĞUL Bünyamin,TOPÇU Ömer,GEDİK Ercan,Baca Bilgi,ERGÜNER İlknur,ASOĞLU Oktar,ERKEK Bülent,Yılmazlar Tuncay,REİS Erhan,GENÇOSMANOĞLU Rasim,Aslar Ahmet Kessaf,Konan Ali Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. , 2019, ss.686 - 694. 10.5152/tjg.2019.17770
AMA Ozturk E,KUZU M,ÖZTUNA D,IŞIK Ö,CANDA A,BALIK E,ERKASAP S,YOLDAŞ T,Akyol C,Demirbas S,ÖZOĞUL B,TOPÇU Ö,GEDİK E,Baca B,ERGÜNER İ,ASOĞLU O,ERKEK B,Yılmazlar T,REİS E,GENÇOSMANOĞLU R,Aslar A,Konan A Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. . 2019; 686 - 694. 10.5152/tjg.2019.17770
Vancouver Ozturk E,KUZU M,ÖZTUNA D,IŞIK Ö,CANDA A,BALIK E,ERKASAP S,YOLDAŞ T,Akyol C,Demirbas S,ÖZOĞUL B,TOPÇU Ö,GEDİK E,Baca B,ERGÜNER İ,ASOĞLU O,ERKEK B,Yılmazlar T,REİS E,GENÇOSMANOĞLU R,Aslar A,Konan A Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. . 2019; 686 - 694. 10.5152/tjg.2019.17770
IEEE Ozturk E,KUZU M,ÖZTUNA D,IŞIK Ö,CANDA A,BALIK E,ERKASAP S,YOLDAŞ T,Akyol C,Demirbas S,ÖZOĞUL B,TOPÇU Ö,GEDİK E,Baca B,ERGÜNER İ,ASOĞLU O,ERKEK B,Yılmazlar T,REİS E,GENÇOSMANOĞLU R,Aslar A,Konan A "Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers." , ss.686 - 694, 2019. 10.5152/tjg.2019.17770
ISNAD Ozturk, Ersin vd. "Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers". (2019), 686-694. https://doi.org/10.5152/tjg.2019.17770
APA Ozturk E, KUZU M, ÖZTUNA D, IŞIK Ö, CANDA A, BALIK E, ERKASAP S, YOLDAŞ T, Akyol C, Demirbas S, ÖZOĞUL B, TOPÇU Ö, GEDİK E, Baca B, ERGÜNER İ, ASOĞLU O, ERKEK B, Yılmazlar T, REİS E, GENÇOSMANOĞLU R, Aslar A, Konan A (2019). Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. Turkish Journal of Gastroenterology, 30(8), 686 - 694. 10.5152/tjg.2019.17770
Chicago Ozturk Ersin,KUZU Mehmet Ayhan,ÖZTUNA Derya,IŞIK Özgen,CANDA Aras Emre,BALIK Emre,ERKASAP Serdar,YOLDAŞ Tayfun,Akyol Cihangir,Demirbas Sezai,ÖZOĞUL Bünyamin,TOPÇU Ömer,GEDİK Ercan,Baca Bilgi,ERGÜNER İlknur,ASOĞLU Oktar,ERKEK Bülent,Yılmazlar Tuncay,REİS Erhan,GENÇOSMANOĞLU Rasim,Aslar Ahmet Kessaf,Konan Ali Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. Turkish Journal of Gastroenterology 30, no.8 (2019): 686 - 694. 10.5152/tjg.2019.17770
MLA Ozturk Ersin,KUZU Mehmet Ayhan,ÖZTUNA Derya,IŞIK Özgen,CANDA Aras Emre,BALIK Emre,ERKASAP Serdar,YOLDAŞ Tayfun,Akyol Cihangir,Demirbas Sezai,ÖZOĞUL Bünyamin,TOPÇU Ömer,GEDİK Ercan,Baca Bilgi,ERGÜNER İlknur,ASOĞLU Oktar,ERKEK Bülent,Yılmazlar Tuncay,REİS Erhan,GENÇOSMANOĞLU Rasim,Aslar Ahmet Kessaf,Konan Ali Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. Turkish Journal of Gastroenterology, vol.30, no.8, 2019, ss.686 - 694. 10.5152/tjg.2019.17770
AMA Ozturk E,KUZU M,ÖZTUNA D,IŞIK Ö,CANDA A,BALIK E,ERKASAP S,YOLDAŞ T,Akyol C,Demirbas S,ÖZOĞUL B,TOPÇU Ö,GEDİK E,Baca B,ERGÜNER İ,ASOĞLU O,ERKEK B,Yılmazlar T,REİS E,GENÇOSMANOĞLU R,Aslar A,Konan A Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. Turkish Journal of Gastroenterology. 2019; 30(8): 686 - 694. 10.5152/tjg.2019.17770
Vancouver Ozturk E,KUZU M,ÖZTUNA D,IŞIK Ö,CANDA A,BALIK E,ERKASAP S,YOLDAŞ T,Akyol C,Demirbas S,ÖZOĞUL B,TOPÇU Ö,GEDİK E,Baca B,ERGÜNER İ,ASOĞLU O,ERKEK B,Yılmazlar T,REİS E,GENÇOSMANOĞLU R,Aslar A,Konan A Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers. Turkish Journal of Gastroenterology. 2019; 30(8): 686 - 694. 10.5152/tjg.2019.17770
IEEE Ozturk E,KUZU M,ÖZTUNA D,IŞIK Ö,CANDA A,BALIK E,ERKASAP S,YOLDAŞ T,Akyol C,Demirbas S,ÖZOĞUL B,TOPÇU Ö,GEDİK E,Baca B,ERGÜNER İ,ASOĞLU O,ERKEK B,Yılmazlar T,REİS E,GENÇOSMANOĞLU R,Aslar A,Konan A "Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers." Turkish Journal of Gastroenterology, 30, ss.686 - 694, 2019. 10.5152/tjg.2019.17770
ISNAD Ozturk, Ersin vd. "Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers". Turkish Journal of Gastroenterology 30/8 (2019), 686-694. https://doi.org/10.5152/tjg.2019.17770