This study evaluates the transformation of a subject’s network through illness and murder and investigates this transformation in the context of the Actor Network Theory and with the example of Persona (Sahsiyet) mini-series. The main motivation of the research originates from the transformation of an individual experience into a social influence and from the possibility that the fiction in Persona may turn into reality in any time. Departing from Diken and Laustsen’s127 principle of “When we talk about film, we talk about society.”, the study approaches the evolution of illness into serial murder from the biopsychosocial point of view and through Merton’s concept of crime that builds upon strain. The results show that an illness may have radical effects on an individual’s life and that accumulating social and institutional fractures such as ignoring in justices may cause individual quests for justice by turning into deep social wounds.