Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 153 - 162 Metin Dili: İngilizce DOI: 10.14744/tjtes.2019.32754 İndeks Tarihi: 05-10-2020

Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study

Öz:
ABSTRACTBACKGROUND: To determine the value of ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in the diagnosis and staging of hemorrhagic shock (HS).METHODS: A pressure-targeted HS model was established in this study. The control and shock groups were monitored for 30 min and 60 min to simulate varying durations of exposure to HS. All subjects underwent invasive arterial monitoring during the experiment and were further divided into mild and severe shock groups based on decreases in mean arterial pressure (MAP). Biochemical and histologic comparisons were performed between the groups.RESULTS: Our results revealed higher IMA, IMAR, lactate, total oxidant status (TOS) and oxidative stress index (OSI) levels in both the 30- and 60-min shock groups compared to the control group. Concerning MAP-based shock staging, IMA, IMAR, lactate, TOS and OSI levels in the 30-min and 60-min mild and severe shock groups were higher than those of the controls. However, there was no significant difference between the mild and severe shock groups. A significant correlation was determined between all the biomarkers evaluated and HS-induced damage in various organs. This correlation was highest in lactate and IMAR levels.CONCLUSION: IMA and IMAR levels may be used in the early diagnosis of HS and also have the potential for use in determining the severity of HS. IMA and IMAR measurement may also be considered as an alternative or in addition to lactate measurement in the diagnosis of HS.
Anahtar Kelime:

Hemorajik şok tanısında ve evrelemesinde iskemi modifiye albümin ve IMA/albümin oranı: Randomize kontrollü deneysel çalışma

Öz:
AMAÇ: Hemorajik şokun (HS) tanı ve evrelemesinde iskemi modifiye albümin (IMA) ve IMA/albümin oranının (IMAR) değerini belirlemek.GEREÇ VE YÖNTEM: Basınç hedefli bir HS modeli oluşturuldu. Kontrol ve şok grupları, HS’ye çeşitli maruz kalma sürelerini simüle etmek için 30 dakika ve 60 dakika boyunca izlendi. Deneyler sırasında tüm deneklere invaziv arter muayenesi yapıldı ve ayrıca ortalama arter basıncı (MAP) azalışlarına dayanarak hafif ve şiddetli şok gruplarına ayrıldı. Gruplar arasında biyokimyasal ve histolojik karşılaştırmalar yapıldı.BULGULAR: Sonuçlarımız kontrol grubuna göre hem 30 hem de 60 dakikalık şok gruplarında IMA, IMAR, laktat, total oksidan durumu (TOS), total antioksidan durumu (TAS) ve oksidatif stres indeksi (OSI) düzeylerini ortaya koydu. MAP bazlı şok evrelemesi açısından, 30 dakikalık ve 60 dakikalık hafif ve şiddetli şok gruplarındaki IMA, IMAR, laktat, TOS ve OSI düzeyleri kontrol grubundan daha yüksekti. Ancak, hafif ve şiddetli şok grupları arasında anlamlı fark yoktu. Değerlendirilen tüm biyobelirteçler ile çeşitli organlarda HS kaynaklı hasar arasında anlamlı korelasyon tespit edildi. Bu korelasyon laktat ve IMAR düzeylerinde en yüksekti.TARTIŞMA: İskemi modifiye albumin ve IMAR düzeyleri HS’nin erken tanısında kullanılabilir ve ayrıca HS’nin şiddetini belirlemede kullanım potansiyeline sahiptir. IMA ve IMAR ölçümü alternatif olarak veya HS tanısında laktat ölçümüne ek olarak düşünülebilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA TÜREDİ S, Sahin A, AKÇA M, Demir S, KÖSE G, ÇEKIÇ A, YILDIRIM M, YULUĞ E, Mentese A, TÜRKMEN S, ACAR S (2020). Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. , 153 - 162. 10.14744/tjtes.2019.32754
Chicago TÜREDİ Süleyman,Sahin Aynur,AKÇA Metehan,Demir Selim,KÖSE Gökçen Derya REİS,ÇEKIÇ ARIF BURAK,YILDIRIM Mehmet,YULUĞ Ersin,Mentese Ahmet,TÜRKMEN Süha,ACAR Sami Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. (2020): 153 - 162. 10.14744/tjtes.2019.32754
MLA TÜREDİ Süleyman,Sahin Aynur,AKÇA Metehan,Demir Selim,KÖSE Gökçen Derya REİS,ÇEKIÇ ARIF BURAK,YILDIRIM Mehmet,YULUĞ Ersin,Mentese Ahmet,TÜRKMEN Süha,ACAR Sami Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. , 2020, ss.153 - 162. 10.14744/tjtes.2019.32754
AMA TÜREDİ S,Sahin A,AKÇA M,Demir S,KÖSE G,ÇEKIÇ A,YILDIRIM M,YULUĞ E,Mentese A,TÜRKMEN S,ACAR S Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. . 2020; 153 - 162. 10.14744/tjtes.2019.32754
Vancouver TÜREDİ S,Sahin A,AKÇA M,Demir S,KÖSE G,ÇEKIÇ A,YILDIRIM M,YULUĞ E,Mentese A,TÜRKMEN S,ACAR S Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. . 2020; 153 - 162. 10.14744/tjtes.2019.32754
IEEE TÜREDİ S,Sahin A,AKÇA M,Demir S,KÖSE G,ÇEKIÇ A,YILDIRIM M,YULUĞ E,Mentese A,TÜRKMEN S,ACAR S "Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study." , ss.153 - 162, 2020. 10.14744/tjtes.2019.32754
ISNAD TÜREDİ, Süleyman vd. "Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study". (2020), 153-162. https://doi.org/10.14744/tjtes.2019.32754
APA TÜREDİ S, Sahin A, AKÇA M, Demir S, KÖSE G, ÇEKIÇ A, YILDIRIM M, YULUĞ E, Mentese A, TÜRKMEN S, ACAR S (2020). Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, 26(2), 153 - 162. 10.14744/tjtes.2019.32754
Chicago TÜREDİ Süleyman,Sahin Aynur,AKÇA Metehan,Demir Selim,KÖSE Gökçen Derya REİS,ÇEKIÇ ARIF BURAK,YILDIRIM Mehmet,YULUĞ Ersin,Mentese Ahmet,TÜRKMEN Süha,ACAR Sami Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.2 (2020): 153 - 162. 10.14744/tjtes.2019.32754
MLA TÜREDİ Süleyman,Sahin Aynur,AKÇA Metehan,Demir Selim,KÖSE Gökçen Derya REİS,ÇEKIÇ ARIF BURAK,YILDIRIM Mehmet,YULUĞ Ersin,Mentese Ahmet,TÜRKMEN Süha,ACAR Sami Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.2, 2020, ss.153 - 162. 10.14744/tjtes.2019.32754
AMA TÜREDİ S,Sahin A,AKÇA M,Demir S,KÖSE G,ÇEKIÇ A,YILDIRIM M,YULUĞ E,Mentese A,TÜRKMEN S,ACAR S Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(2): 153 - 162. 10.14744/tjtes.2019.32754
Vancouver TÜREDİ S,Sahin A,AKÇA M,Demir S,KÖSE G,ÇEKIÇ A,YILDIRIM M,YULUĞ E,Mentese A,TÜRKMEN S,ACAR S Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(2): 153 - 162. 10.14744/tjtes.2019.32754
IEEE TÜREDİ S,Sahin A,AKÇA M,Demir S,KÖSE G,ÇEKIÇ A,YILDIRIM M,YULUĞ E,Mentese A,TÜRKMEN S,ACAR S "Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.153 - 162, 2020. 10.14744/tjtes.2019.32754
ISNAD TÜREDİ, Süleyman vd. "Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study". Ulusal Travma ve Acil Cerrahi Dergisi 26/2 (2020), 153-162. https://doi.org/10.14744/tjtes.2019.32754