Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode
Yıl: 2020 Cilt: 22 Sayı: 64 Sayfa Aralığı: 29 - 35 Metin Dili: İngilizce DOI: 10.21205/deufmd.2020226404 İndeks Tarihi: 30-10-2020
Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode
Öz: The electrochemical behavior of Pravastatin, a lipid-lowering drug, on a glassy carbon electrode wasexplored in Britton-Robinson buffer by using cyclic and square-wave voltammetry. Cyclicvoltammetric studies indicated that the compound underwent irreversible oxidation, which was adiffusion-controlled process. Using square-wave voltammetry, Pravastatin could be determined at+1.24 V (vs. Ag/AgCl) in the concentration range 2.4×10-7-2.8×10-6 M at pH 2.0, with a detectionlimit of 5.0×10-8 M. The suggested method was successfully applied for the assay of Pravastatin intablets.
Anahtar Kelime: Pravastatin’in Camımsı Karbon Elektrot Üzerinde Karedalga Voltametrisi ile İlaç Formülasyonunda Tayini
Öz: Lipit düşürücü ilaç olan Pravastatin′in, camımsı karbon elektrot üzerindeki elektrokimyasal davranışı, Britton-Robinson tamponu içerisinde dönüşümlü voltametri ve kare-dalga voltametrisi teknikleri kullanılarak araştırılmıştır. Dönüşümlü voltametrik çalışmalar, molekülün tersinmez olarak yürüyen yükseltgenmesinin difüzyon-kontrollü olduğunu göstermiştir. Kare-dalga voltametrisi kullanılarak, Pravastatin′in pH 2.0 değerinde +1.24 V (vs. Ag/AgCl) gerilim değerinde 2.4×10-7-2.8×10-6 M derişim aralığında (saptama sınırı, 5.0×10-8 M) tayini gerçekleştirilmiştir. Önerilen yöntem, Pravastatin′in tablet ilaç şeklinden tayinine başarıyla uygulanmıştır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | TALAY PINAR P, TULUK T, Şentürk Z (2020). Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. , 29 - 35. 10.21205/deufmd.2020226404 |
Chicago | TALAY PINAR PINAR,TULUK Tamer,Şentürk Zühre Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. (2020): 29 - 35. 10.21205/deufmd.2020226404 |
MLA | TALAY PINAR PINAR,TULUK Tamer,Şentürk Zühre Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. , 2020, ss.29 - 35. 10.21205/deufmd.2020226404 |
AMA | TALAY PINAR P,TULUK T,Şentürk Z Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. . 2020; 29 - 35. 10.21205/deufmd.2020226404 |
Vancouver | TALAY PINAR P,TULUK T,Şentürk Z Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. . 2020; 29 - 35. 10.21205/deufmd.2020226404 |
IEEE | TALAY PINAR P,TULUK T,Şentürk Z "Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode." , ss.29 - 35, 2020. 10.21205/deufmd.2020226404 |
ISNAD | TALAY PINAR, PINAR vd. "Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode". (2020), 29-35. https://doi.org/10.21205/deufmd.2020226404 |
APA | TALAY PINAR P, TULUK T, Şentürk Z (2020). Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi, 22(64), 29 - 35. 10.21205/deufmd.2020226404 |
Chicago | TALAY PINAR PINAR,TULUK Tamer,Şentürk Zühre Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi 22, no.64 (2020): 29 - 35. 10.21205/deufmd.2020226404 |
MLA | TALAY PINAR PINAR,TULUK Tamer,Şentürk Zühre Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi, vol.22, no.64, 2020, ss.29 - 35. 10.21205/deufmd.2020226404 |
AMA | TALAY PINAR P,TULUK T,Şentürk Z Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi. 2020; 22(64): 29 - 35. 10.21205/deufmd.2020226404 |
Vancouver | TALAY PINAR P,TULUK T,Şentürk Z Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi. 2020; 22(64): 29 - 35. 10.21205/deufmd.2020226404 |
IEEE | TALAY PINAR P,TULUK T,Şentürk Z "Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode." Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi, 22, ss.29 - 35, 2020. 10.21205/deufmd.2020226404 |
ISNAD | TALAY PINAR, PINAR vd. "Determination of Pravastatin Drug Formulation by Squarewave Voltammetry on Glassy Carbon Elektrode". Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi 22/64 (2020), 29-35. https://doi.org/10.21205/deufmd.2020226404 |