Evaluation of seasonal relationship with vitamin D levels in Van region

alp, hamit hakan; üçler, rıfkı; BALAHAROĞLU, Ragıp; HUYUT, Zübeyir; ŞEKEROĞLU, Mehmet Ramazan; ÇOKLUK, erdem

doi:10.30565/medalanya.463904

Evaluation of seasonal relationship with vitamin D levels in Van region

Ragıp BALAHAROĞLU, (Konya Eğitim ve Araştırma Hastanesi, Klinik Biyokimya Kliniği, Konya, Türkiye)

Erdem ÇOKLUK, (Sakarya Üniversitesi, Tıp Fakültesi, Klinik Biyokimya Anabilim Dalı, Sakarya, Türkiye)

Hamit Hakan ALP, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Van, Türkiye)

Rıfkı ÜÇLER, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Van, Türkiye)

Mehmet Ramazan ŞEKEROĞLU, (Sakarya Üniversitesi, Tıp Fakültesi, Klinik Biyokimya Anabilim Dalı, Sakarya, Türkiye)

Zübeyir HUYUT (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Van, Türkiye)

Acta Medica Alanya

0 1

Yıl: 2019 Cilt: 3 Sayı: 2 Sayfa Aralığı: 124 - 128 Metin Dili: İngilizce DOI: 10.30565/medalanya.463904 İndeks Tarihi: 12-11-2020

Evaluation of seasonal relationship with vitamin D levels in Van region

Öz:

Aim: Vitamin D is a fat-soluble vitamin which is found in certain foods and can besynthesized from its precursors with exposure of sunlight. It is known that serum 25-hydroxy vitamin D (25-OH Vit D) concentration is the best indicator of Vitamin Dlevel. Main source of Vitamin D is the synthesis to the skin with sunlight exposure. Inour study we investigated the vitamin D levels of patients administered to our hospitalin Van. We aimed to determine any significant difference between age, sex and seasonal differences of the 25-OH vit D levels.Materials and Method: Patients admitted to Yuzuncu Yil University Faculty ofMedicine Dursun Odabas Medical Hospital from 01.01.2013 to 01.01.2014 with 25-OH vit D levels were determined and evaluated respectively.Results: Mean age for males (n=306) was found as 46.65±16.62 and for females(n=1613) as 43.58±15.03. Mean 25-OH vit D in males was found as 18.95±7.93 ng/mL and in females it was found as 14.79±9.42 ng/ml. 25-OH vit D levels of maleswere found significantly higher than that of females (p<0.05). When 25-OH vit Dlevels were analyzed according to season, a mean of 25-OH vit D for the summerseason was found significantly higher than those of the winter or autumn-springmonths (p=0.006). Although Van receives one of the highest amount of sunlight dueto its geographical position, we consider that there exists a deficiency in all agegroups in the society, for all seasons.Conclusions: According to these findings we conclude that both nutritional supportand Vitamin D supplementation is important for recovery of vitamin D deficiency inand around the city of Van.

Anahtar Kelime:

Van yöresinde D vitamini düzeyleri ile mevsimsel ilişkinin değerlendirilmesi

Öz:

Amaç: D vitamini, bazı gıdalarda bulunan ve güneş ışığına maruz kalan öncülerinden sentezlenebilen yağda çözünen bir vitamindir. Serum 25-hidroksi vitamin D (25-OH Vit D) konsantrasyonunun Vitamin D seviyesinin en iyi göstergesi olduğu bilinmektedir. D vitamininin ana kaynağı güneş ışığına maruz kalan ciltten sentez edilmesidir. Çalışmada Van'da hastanemize başvuran hastaların D vitamini düzeylerini geriye yönelik taradık. 25-OH vit D düzeylerinin yaş, cinsiyet ve mevsimsel farklılıkları arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dursun Odabaş Tıp Merkezine başvuran 01.01.2013 - 01.01.2014 tarihleri arasında 25-OH vit D düzeyleri tespit edilen ve kriterleri sağlayan sonuçlar dahil edildi. Bulgular: Erkeklerin yaş ortalaması (n = 306) 46.65 ± 16.62, kadınlarda (n = 1613) 43.58 ± 15.03 olarak bulundu. Erkeklerde ortalama 25-OH vit D 18.95 ± 7.93 ng / mL ve kadınlarda 14.79 ± 9.42 ng / ml olarak bulundu. Erkeklerin 25-OH D vitamini düzeyleri kadınlardan anlamlı derecede yüksek bulundu (p <0.05). Mevsime göre 25-OH D vitamini seviyeleri analiz edildiğinde, yaz mevsimi için 25-OH Vitamin D ortalaması kış mevsimine ya da Sonbahar-İlkbahar aylarına göre anlamlı olarak yüksekti (p = 0,006). Sonuç: Her ne kadar Van, konumu itibariyle en çok güneş alan şehirler arasında olsa da, tüm mevsimler ve yaş gruplarına göre vitamin D düzeylerinin düşük olduğunu düşünüyoruz. Bu bulgulara göre, Van ilindeki ve çevresindeki vitamin D eksikliğinin düzelmesi için hem beslenme desteğinin hem de D vitamini desteğinin önemli olduğu sonucuna vardık.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Holick MF. Vitamin D deficiency. The New England journal of medicine. 2007 19;357(3):266-81. PMID: 17634462.
2. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Therapeutic advances in endocrinology and metabolism. 2013 4(4):122-8. PubMed PMID: 23997931. PMCID: 3755528.
3. Pilz S, Gaksch M, O'Hartaigh B, Tomaschitz A, Marz W. The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013? Archives of toxicology. 2013;87(12):2083-103. PMID: 24173581.
4. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: Pooled analysis. J Steroid Biochem. 2007;103(3-5):708-11. PMID: 17368188
5. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. Jama-J Am Med Assoc. 2006 20;296(23):2832-8. PMID: 17179460
6. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Archives of gerontology and geriatrics. 2005;40(1):53-60. PMID: 15531023.
7. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem 2010;121(1- 2):297-300. PMID: 20197091
8. Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72 ': evidence of deficiency. J Perinatol. 2007;27(9):568-71. PMID: 17625571
9. Huotari A, Herzig KH. Vitamin D and living in northern latitudes - An endemic risk area for vitamin D deficiency. Int J Circumpol Heal. 2008;67(2-3):164-78. PMID: 18767337
10. Aslan A, Karakoyun O, Güler E, Aydin S, Gök MV, Akkurt S. Evaluation of bone mineral density, osteoporosis prevalence and regional risk factors in Turkish women living in Kastamonu: KASTÜRKOS study. Eklem Hastalik Cerrahisi. 2012;23(2):62- 7. Turkish. PMID: 22765482
11. Gülcü A, Özen Ö. The Bone Mineral Density Values of Women in Alanya and Regional Turkish Community: Cross-sectional Comparative Study. Acta Medica Alanya 2018;2(2):111-115. DOI:10.30565/medalanya.426939
12. EIE. Güneş enerjisi potansiyel atlası: Yenilenebilir Enerji Genel Müdürlüğü; 2014.
13. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001;22(4):477-501. PMID: 11493580
14. van Schoor NM, Lips P. Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism. 2011;25(4):671-80. PMID: 21872807.
15. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC public health. 2004 25;4:38. PMID: 15327695.
16. Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Hormone research. 2005;64(3):144-8. PMID: 16192739.
17. Sedrani SH, Elidrissy AW, El Arabi KM. Sunlight and vitamin D status in normal Saudi subjects. The American journal of clinical nutrition. 1983;38(1):129-32. PMID: 6602540.
18. Aspray TJ, Yan L, Prentice A. Parathyroid hormone and rates of bone formation are raised in perimenopausal rural Gambian women. Bone. 2005;36(4):710-20. PMID: 15780975.
19. M'Buyamba-Kabangu JR, Fagard R, Lijnen P, Bouillon R, Lissens W, Amery A. Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males. Calcified tissue international. 1987;41(2):70-4. PMID: 3115547.
20. Haarburger D, Hoffman M, Erasmus RT, Pillay TS. Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. J Clin Pathol. 2009;62(6):567-9. PMID: 19213756
21. Alagol F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizleri H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest. 2000;23(3):173-7. PMID: 10803475
22. Joh H-K, Seung-sik H, Cho B, Lim CS, Jung S-E. Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial. Clinical Nutrition. 2019. DOI: 10.1016/j. clnu.2019.03.021
23. Pierret L, Suppa M, Gandini S, Del Marmol V, Gutermuth J. Overview on vitamin D and sunbed use. Journal of the European Academy of Dermatology and Venereology. 2019;33:28-33. DOI: 10.1111/jdv.15316.
24. Alamoudi LH, Almuteeri RZ, Al-Otaibi ME, Alshaer DA, Fatani SK, Alghamdi MM, et al. Awareness of Vitamin D Deficiency among the General Popula-tion in Jeddah, Saudi Arabia. J Nutr Metab. 2019 Mar 3;2019:4138187. DOI: 10.1155/2019/4138187

APA	BALAHAROĞLU R, ÇOKLUK e, alp h, üçler r, ŞEKEROĞLU M, HUYUT Z (2019). Evaluation of seasonal relationship with vitamin D levels in Van region. , 124 - 128. 10.30565/medalanya.463904
Chicago	BALAHAROĞLU Ragıp,ÇOKLUK erdem,alp hamit hakan,üçler rıfkı,ŞEKEROĞLU Mehmet Ramazan,HUYUT Zübeyir Evaluation of seasonal relationship with vitamin D levels in Van region. (2019): 124 - 128. 10.30565/medalanya.463904
MLA	BALAHAROĞLU Ragıp,ÇOKLUK erdem,alp hamit hakan,üçler rıfkı,ŞEKEROĞLU Mehmet Ramazan,HUYUT Zübeyir Evaluation of seasonal relationship with vitamin D levels in Van region. , 2019, ss.124 - 128. 10.30565/medalanya.463904
AMA	BALAHAROĞLU R,ÇOKLUK e,alp h,üçler r,ŞEKEROĞLU M,HUYUT Z Evaluation of seasonal relationship with vitamin D levels in Van region. . 2019; 124 - 128. 10.30565/medalanya.463904
Vancouver	BALAHAROĞLU R,ÇOKLUK e,alp h,üçler r,ŞEKEROĞLU M,HUYUT Z Evaluation of seasonal relationship with vitamin D levels in Van region. . 2019; 124 - 128. 10.30565/medalanya.463904
IEEE	BALAHAROĞLU R,ÇOKLUK e,alp h,üçler r,ŞEKEROĞLU M,HUYUT Z "Evaluation of seasonal relationship with vitamin D levels in Van region." , ss.124 - 128, 2019. 10.30565/medalanya.463904
ISNAD	BALAHAROĞLU, Ragıp vd. "Evaluation of seasonal relationship with vitamin D levels in Van region". (2019), 124-128. https://doi.org/10.30565/medalanya.463904

APA	BALAHAROĞLU R, ÇOKLUK e, alp h, üçler r, ŞEKEROĞLU M, HUYUT Z (2019). Evaluation of seasonal relationship with vitamin D levels in Van region. Acta Medica Alanya, 3(2), 124 - 128. 10.30565/medalanya.463904
Chicago	BALAHAROĞLU Ragıp,ÇOKLUK erdem,alp hamit hakan,üçler rıfkı,ŞEKEROĞLU Mehmet Ramazan,HUYUT Zübeyir Evaluation of seasonal relationship with vitamin D levels in Van region. Acta Medica Alanya 3, no.2 (2019): 124 - 128. 10.30565/medalanya.463904
MLA	BALAHAROĞLU Ragıp,ÇOKLUK erdem,alp hamit hakan,üçler rıfkı,ŞEKEROĞLU Mehmet Ramazan,HUYUT Zübeyir Evaluation of seasonal relationship with vitamin D levels in Van region. Acta Medica Alanya, vol.3, no.2, 2019, ss.124 - 128. 10.30565/medalanya.463904
AMA	BALAHAROĞLU R,ÇOKLUK e,alp h,üçler r,ŞEKEROĞLU M,HUYUT Z Evaluation of seasonal relationship with vitamin D levels in Van region. Acta Medica Alanya. 2019; 3(2): 124 - 128. 10.30565/medalanya.463904
Vancouver	BALAHAROĞLU R,ÇOKLUK e,alp h,üçler r,ŞEKEROĞLU M,HUYUT Z Evaluation of seasonal relationship with vitamin D levels in Van region. Acta Medica Alanya. 2019; 3(2): 124 - 128. 10.30565/medalanya.463904
IEEE	BALAHAROĞLU R,ÇOKLUK e,alp h,üçler r,ŞEKEROĞLU M,HUYUT Z "Evaluation of seasonal relationship with vitamin D levels in Van region." Acta Medica Alanya, 3, ss.124 - 128, 2019. 10.30565/medalanya.463904
ISNAD	BALAHAROĞLU, Ragıp vd. "Evaluation of seasonal relationship with vitamin D levels in Van region". Acta Medica Alanya 3/2 (2019), 124-128. https://doi.org/10.30565/medalanya.463904