Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?
Yıl: 2020 Cilt: 25 Sayı: 3 Sayfa Aralığı: 383 - 387 Metin Dili: İngilizce DOI: 10.5505/ejm.2020.57689 İndeks Tarihi: 17-11-2020
Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?
Öz: Studies reported that phosphodiesterase-5 inhibitors (PDE-5Is) positively contributed to bone-mineral-density and thickness inrats with ovariectomy, which have the same condition with postmenapozal period. To explain the positive contributionmechanism on bone mineral density of PDE-5Is, we investigated the effect of zaprinast and avanafil on levels of some pro -oranti-resorptive cytokines in ovariectomized-rats.Albino female rats (8 months and 250-350 g) were used and four groups of equal-number were randomly assigned (n=6). Groups;was the sahm operated, positive control (OVX), Zaprinast and OVX, Avanafil and OVX groups, respectively. The levels ofEstrogen, IL-1β, IL-6, IL-8, IL-10 and TNF-α were measured by ELISA kits, in liver of rats.IL-1β, IL-6, IL-8 and TNF-α levels were high in groups with OVX compared to sham group, while IL-10 levels were low. Also,IL-1β, IL-6, IL-8 and TNF-α levels were low in zaprinast and especially avanafil-treated groups with OVX and were similar to thesahm group values (p=0.001 for IL-1β, p=0.045 for IL-6, p=0.008 for IL-8, p=0.006 for IL-10, p=0.026 for TNF-α).Zaprinast and especially avanafil inhibited IL-1β, 8 and TNF-α and increased the IL-10 levels compared to the OVX group. Thismay support opinion that PDE-5Is enhance bone mineralization by inhibiting proresorptive cytokines.
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| APA | Huyut Z, Bakan N, ÇOKLUK e, AKBAY H, alp h, Şekeroğlu M (2020). Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. , 383 - 387. 10.5505/ejm.2020.57689 |
| Chicago | Huyut Zübeyir,Bakan Nuri,ÇOKLUK erdem,AKBAY HALİL İBRAHİM,alp hamit hakan,Şekeroğlu Mehmet Ramazan Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. (2020): 383 - 387. 10.5505/ejm.2020.57689 |
| MLA | Huyut Zübeyir,Bakan Nuri,ÇOKLUK erdem,AKBAY HALİL İBRAHİM,alp hamit hakan,Şekeroğlu Mehmet Ramazan Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. , 2020, ss.383 - 387. 10.5505/ejm.2020.57689 |
| AMA | Huyut Z,Bakan N,ÇOKLUK e,AKBAY H,alp h,Şekeroğlu M Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. . 2020; 383 - 387. 10.5505/ejm.2020.57689 |
| Vancouver | Huyut Z,Bakan N,ÇOKLUK e,AKBAY H,alp h,Şekeroğlu M Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. . 2020; 383 - 387. 10.5505/ejm.2020.57689 |
| IEEE | Huyut Z,Bakan N,ÇOKLUK e,AKBAY H,alp h,Şekeroğlu M "Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?." , ss.383 - 387, 2020. 10.5505/ejm.2020.57689 |
| ISNAD | Huyut, Zübeyir vd. "Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?". (2020), 383-387. https://doi.org/10.5505/ejm.2020.57689 |
| APA | Huyut Z, Bakan N, ÇOKLUK e, AKBAY H, alp h, Şekeroğlu M (2020). Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. Eastern Journal of Medicine, 25(3), 383 - 387. 10.5505/ejm.2020.57689 |
| Chicago | Huyut Zübeyir,Bakan Nuri,ÇOKLUK erdem,AKBAY HALİL İBRAHİM,alp hamit hakan,Şekeroğlu Mehmet Ramazan Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. Eastern Journal of Medicine 25, no.3 (2020): 383 - 387. 10.5505/ejm.2020.57689 |
| MLA | Huyut Zübeyir,Bakan Nuri,ÇOKLUK erdem,AKBAY HALİL İBRAHİM,alp hamit hakan,Şekeroğlu Mehmet Ramazan Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. Eastern Journal of Medicine, vol.25, no.3, 2020, ss.383 - 387. 10.5505/ejm.2020.57689 |
| AMA | Huyut Z,Bakan N,ÇOKLUK e,AKBAY H,alp h,Şekeroğlu M Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. Eastern Journal of Medicine. 2020; 25(3): 383 - 387. 10.5505/ejm.2020.57689 |
| Vancouver | Huyut Z,Bakan N,ÇOKLUK e,AKBAY H,alp h,Şekeroğlu M Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?. Eastern Journal of Medicine. 2020; 25(3): 383 - 387. 10.5505/ejm.2020.57689 |
| IEEE | Huyut Z,Bakan N,ÇOKLUK e,AKBAY H,alp h,Şekeroğlu M "Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?." Eastern Journal of Medicine, 25, ss.383 - 387, 2020. 10.5505/ejm.2020.57689 |
| ISNAD | Huyut, Zübeyir vd. "Do Avanafil and Zaprinast Change Some Selected Cytokine Levels In Ovariectomized Rat’s Liver?". Eastern Journal of Medicine 25/3 (2020), 383-387. https://doi.org/10.5505/ejm.2020.57689 |
