Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

Ekinci Akdemir, Fazile Nur; tanyeli, ayhan; guler, mustafa can; NACAR, TUNCER; topdağı, ömer; Eraslan, Ersen

doi:10.9775/kvfd.2019.23250

Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

Mustafa Can GÜLER, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Ayhan TANYELİ, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Ersen ERASLAN, (Bozok Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Yozgat, Türkiye)

Fazile Nur EKİNCİ AKDEMİR, (Ağrı İbrahim Çeçen Üniversitesi, Beslenme ve Diyetetik Bölümü, Sağlık Yüksek Okulu, Ağrı, Türkiye)

Ömer TOPDAĞI, (Atatürk Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Erzurum, Türkiye)

Tuncer NACAR (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2020 Cilt: 26 Sayı: 3 Sayfa Aralığı: 365 - 370 Metin Dili: İngilizce DOI: 10.9775/kvfd.2019.23250 İndeks Tarihi: 01-12-2020

Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

Öz:

The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In thisstudy, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, andischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the endof the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidantparameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant andinflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These resultshave demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemiareperfusion.

Anahtar Kelime:

Higenamin Ratlarda İskemi Reperfüzyonunun Neden Olduğu Oksidatif Böbrek Hasarını Azaltır

Öz:

Bu araştırmanın amacı, higenaminin, iskemi reperfüzyonunun neden olduğu böbrek dokusu hasarı üzerine koruyucu etkilerini belirlemektir. Bu araştırmada 24 adet Sprague Dawley dişi sıçan üç gruba ayrıldı. Bu çalışmanın grupları aşağıdaki şekilde tasarlanmıştır; kontrol, iskemi reperfüzyon ve iskemi reperfüzyon + higenamin grupları. Deney sonunda elde edilen böbrek dokularındaki bazı oksidan, antioksidan ve inflamatuvar parametreler değerlendirildi. İskemi reperfüzyon grubu kontrol grubu ile kıyaslandığında, böbrek dokusundaki oksidan ve inflamatuvar parametrelerin arttığı fakat antioksidan parametrelerin azaldığı belirlendi. Tedavi grubu (iskemi reperfüzyon + higenamin) yalnızca iskemi reperfüzyon grubu ile kıyaslandığında antioksidan parametreler artarken, oksidan ve inflamatuvar parametreler azaldı. Bu sonuçlar, tek doz higenamin uygulamasının, iskemi reperfüzyon kaynaklı oksidatif böbrek hasarına karşı etkili olduğunu göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	guler m, tanyeli a, Eraslan E, Ekinci Akdemir F, topdağı ö, NACAR T (2020). Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. , 365 - 370. 10.9775/kvfd.2019.23250
Chicago	guler mustafa can,tanyeli ayhan,Eraslan Ersen,Ekinci Akdemir Fazile Nur,topdağı ömer,NACAR TUNCER Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. (2020): 365 - 370. 10.9775/kvfd.2019.23250
MLA	guler mustafa can,tanyeli ayhan,Eraslan Ersen,Ekinci Akdemir Fazile Nur,topdağı ömer,NACAR TUNCER Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. , 2020, ss.365 - 370. 10.9775/kvfd.2019.23250
AMA	guler m,tanyeli a,Eraslan E,Ekinci Akdemir F,topdağı ö,NACAR T Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. . 2020; 365 - 370. 10.9775/kvfd.2019.23250
Vancouver	guler m,tanyeli a,Eraslan E,Ekinci Akdemir F,topdağı ö,NACAR T Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. . 2020; 365 - 370. 10.9775/kvfd.2019.23250
IEEE	guler m,tanyeli a,Eraslan E,Ekinci Akdemir F,topdağı ö,NACAR T "Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats." , ss.365 - 370, 2020. 10.9775/kvfd.2019.23250
ISNAD	guler, mustafa can vd. "Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats". (2020), 365-370. https://doi.org/10.9775/kvfd.2019.23250

APA	guler m, tanyeli a, Eraslan E, Ekinci Akdemir F, topdağı ö, NACAR T (2020). Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 26(3), 365 - 370. 10.9775/kvfd.2019.23250
Chicago	guler mustafa can,tanyeli ayhan,Eraslan Ersen,Ekinci Akdemir Fazile Nur,topdağı ömer,NACAR TUNCER Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 26, no.3 (2020): 365 - 370. 10.9775/kvfd.2019.23250
MLA	guler mustafa can,tanyeli ayhan,Eraslan Ersen,Ekinci Akdemir Fazile Nur,topdağı ömer,NACAR TUNCER Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.26, no.3, 2020, ss.365 - 370. 10.9775/kvfd.2019.23250
AMA	guler m,tanyeli a,Eraslan E,Ekinci Akdemir F,topdağı ö,NACAR T Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2020; 26(3): 365 - 370. 10.9775/kvfd.2019.23250
Vancouver	guler m,tanyeli a,Eraslan E,Ekinci Akdemir F,topdağı ö,NACAR T Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2020; 26(3): 365 - 370. 10.9775/kvfd.2019.23250
IEEE	guler m,tanyeli a,Eraslan E,Ekinci Akdemir F,topdağı ö,NACAR T "Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 26, ss.365 - 370, 2020. 10.9775/kvfd.2019.23250
ISNAD	guler, mustafa can vd. "Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 26/3 (2020), 365-370. https://doi.org/10.9775/kvfd.2019.23250