Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis
Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 25 - 29 Metin Dili: İngilizce DOI: 10.14744/epilepsi.2019.86648 İndeks Tarihi: 09-12-2020
Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis
Öz: Objectives: It has been proposed that olfactory function disorders, such as parosmia or hyposmia, were associated with mesial temporal lobeepilepsy with hippocampal sclerosis (MTLE-HS). In this study, we aimed to compare the olfactory function and its subtypes between MTLE-HSand healthy controls.Methods: We recruited 22 non-operated consecutive patients diagnosed with MTLE-HS and 22 aged and gender-matched healthy controls(HC). After a detailed clinical evaluation, we used a standardized tool, Sniffin’ Sticks test, to evaluate the olfactory function.Results: The mean age was 37.5 (±12.7) years in the MTLE-HS group and 36.9 (±10.3) years in the HC group. There were 14 females and eightmales in both groups. Threshold, discrimination, identification and TDI scores were analyzed separately for each group. The threshold anddiscrimination values were similar in MTLE-HS and HC groups (p=0.063). Identification and TDI scores were significantly lower in the MTLE-HSgroup, respectively p<0.01 and p<0.001.Conclusion: We have demonstrated the impaired olfactory function in MTLE-HS patients in the Turkish population. For the MTLE-HS patients,both peripheral changes, as well as structural or functional alterations in mesial temporal lobes and prefrontal lobes, have been proposed, andour results are in favor of central involvement.
Anahtar Kelime: Hipokampal Skleroz ile İlişkili Mezial Temporal Lob Epilepsili Hastalarda Koku Duyusunun Değerlendirilmesi
Öz: Amaç: Hiposmi, parosmi gibi koku duyusundaki çeşitli bozuklukların hipokampal skleroza bağlı mezial temporal lob epilepsisi (HS-MTS) ile ilişkili olduğu düşünülmektedir. Bu çalışmada, HS-MTS tanısı ile takip edilen hastaların koku fonksiyonlarının sağlıklı bireylerle karşılaştırılması ve koku duyusundaki değişimlerin ayrıntılı olarak tanımlanması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya HS-MTS tanılı, epilepsi cerrahisi öykü olmayan 22 hasta ile yaş ve cinsiyet eşlenmiş 22 sağlıklı birey kontrol grubu olarak dahil edilmiştir. Ayrıntılı klinik değerlendirme sonrasında, her iki grupta koku duyusunu değerlendirmek ve karşılaştırmak için Sniffin’ Sticks koku testi kullanılmıştır. Bulgular: HS-MTS grubunu yaş ortalaması 37.5 (±12.7); kontrol grubunun yaş ortalaması 36.9 (±10.3) idi. Her iki grupta 14 kadın ve sekiz erkek birey vardı. Koku duyusu değerlendirilmesi kapsamında koku eşik, koku ayrım ve koku saptama alt grupları hesaplanarak karşılaştırıldı. Eşik değer ve ayrım skorları her iki grupta benzer iken (p=0.063), EAS (eşik-ayrım -saptama) toplam skoru ve koku saptama skorları HS-MTS grubunda anlamlı şekilde düşük bulundu (p<0.01 ve p<0.001). Sonuç: HS-MTS’li bireylerde koku duyusu belirgin şekilde etkilenmiştir. Katılımcı sayısı sınırlı olmakla beraber HS lateralizasyonu koku duyusundaki bozulma ile ilişkili olabilir. Koku duyusundaki mevcut etkilenim mezial ve temporal loblardaki yapısal ve/veya fonksiyonel değişimlere ikincil olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Sezgin M, Samanci B, Sen C, SAMANCI M, BEBEK N, Orhan K, KURT B (2020). Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. , 25 - 29. 10.14744/epilepsi.2019.86648 |
| Chicago | Sezgin Mine,Samanci Bedia,Sen Comert,SAMANCI Mustafa Yavuz,BEBEK Nerses,Orhan Kadir Serkan,KURT Betül Baykan Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. (2020): 25 - 29. 10.14744/epilepsi.2019.86648 |
| MLA | Sezgin Mine,Samanci Bedia,Sen Comert,SAMANCI Mustafa Yavuz,BEBEK Nerses,Orhan Kadir Serkan,KURT Betül Baykan Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. , 2020, ss.25 - 29. 10.14744/epilepsi.2019.86648 |
| AMA | Sezgin M,Samanci B,Sen C,SAMANCI M,BEBEK N,Orhan K,KURT B Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. . 2020; 25 - 29. 10.14744/epilepsi.2019.86648 |
| Vancouver | Sezgin M,Samanci B,Sen C,SAMANCI M,BEBEK N,Orhan K,KURT B Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. . 2020; 25 - 29. 10.14744/epilepsi.2019.86648 |
| IEEE | Sezgin M,Samanci B,Sen C,SAMANCI M,BEBEK N,Orhan K,KURT B "Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis." , ss.25 - 29, 2020. 10.14744/epilepsi.2019.86648 |
| ISNAD | Sezgin, Mine vd. "Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis". (2020), 25-29. https://doi.org/10.14744/epilepsi.2019.86648 |
| APA | Sezgin M, Samanci B, Sen C, SAMANCI M, BEBEK N, Orhan K, KURT B (2020). Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. Epilepsi, 26(1), 25 - 29. 10.14744/epilepsi.2019.86648 |
| Chicago | Sezgin Mine,Samanci Bedia,Sen Comert,SAMANCI Mustafa Yavuz,BEBEK Nerses,Orhan Kadir Serkan,KURT Betül Baykan Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. Epilepsi 26, no.1 (2020): 25 - 29. 10.14744/epilepsi.2019.86648 |
| MLA | Sezgin Mine,Samanci Bedia,Sen Comert,SAMANCI Mustafa Yavuz,BEBEK Nerses,Orhan Kadir Serkan,KURT Betül Baykan Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. Epilepsi, vol.26, no.1, 2020, ss.25 - 29. 10.14744/epilepsi.2019.86648 |
| AMA | Sezgin M,Samanci B,Sen C,SAMANCI M,BEBEK N,Orhan K,KURT B Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. Epilepsi. 2020; 26(1): 25 - 29. 10.14744/epilepsi.2019.86648 |
| Vancouver | Sezgin M,Samanci B,Sen C,SAMANCI M,BEBEK N,Orhan K,KURT B Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis. Epilepsi. 2020; 26(1): 25 - 29. 10.14744/epilepsi.2019.86648 |
| IEEE | Sezgin M,Samanci B,Sen C,SAMANCI M,BEBEK N,Orhan K,KURT B "Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis." Epilepsi, 26, ss.25 - 29, 2020. 10.14744/epilepsi.2019.86648 |
| ISNAD | Sezgin, Mine vd. "Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis". Epilepsi 26/1 (2020), 25-29. https://doi.org/10.14744/epilepsi.2019.86648 |
