[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini

uzun, demet; hasdemir, erdoğan; Tabanlıgil Calam, Tuğba; Turan, Onder

doi:10.17341/gazimmfd.525552

[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini

Önder TURAN, (Marmara Üniversitesi, Kimya Öğretmenliği Bölümü, İstanbul, Türkiye)

Tuğba TABANLIGİL CALAM, (Gazi Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Ankara, Türkiye)

Demet UZUN, (Gazi Üniversitesi, Fen Fakültesi, Kimya Bölümü, Ankara, Türkiye)

Erdoğan HASDEMİR (Gazi Üniversitesi, Fen Fakültesi, Kimya Bölümü, Ankara, Türkiye)

Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi

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Yıl: 2020 Cilt: 35 Sayı: 4 Sayfa Aralığı: 2013 - 2022 Metin Dili: Türkçe DOI: 10.17341/gazimmfd.525552 İndeks Tarihi: 14-01-2021

[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini

Öz:

Bu çalışmada, bir triazol türevi olan [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol (TMN-2-ol) Schiff bazıile platin (Pt) elektrot yüzeyi kaplanarak; TMN-2-ol/Pt elektrodu hazırlanmıştır. Kaplama işlemi, dönüşümlüvoltametri (CV) yöntemi kullanılarak 110-3 M TMN-2-ol çözeltisi içerisinde, 100 mV s-1 tarama hızıyla -0,8 V ile +2,0 V potansiyelleri arasında, 40 çevrim sayısı ile gerçekleştirilmiştir. Hazırlanan modifiye yüzey,CV, temas açısı (CAM) ve yansıtmalı absorpsiyon infrared spektroskopisi (RAIRS) yöntemleri kullanılarakkarakterize edilmiştir. Hazırlanan ve karakterize edilen elektrodun askorbik asit (AA) ve dopamin (DA)varlığında ürik aside (ÜA) olan elektrokatalitik duyarlılığı, kare dalga voltametrisi (SWV) yöntemiyleincelenmiştir. Destek elektrolit, pH gibi optimum çalışma şartları belirlenmiştir. En uygun çalışma ortamı0,1 M pH 7,2 fosfat tamponu (PBS) olarak bulunmuştur. TMN-2-ol/Pt elektrot ile ÜA için çalışma aralığı1,2310-6–1,5110-5 M ve gözlenebilme sınırı (LOD) 1,5610-8 M olarak belirlenmiştir. ÜA’nın pik akımıüzerine çeşitli anyon ve katyonların girişim etkileri incelenmiştir. Modifiye elektrotla, insan kan serumundastandart ekleme yöntemi kullanarak düşük bir bağıl standart sapma değerleri ile ÜA analizigerçekleştirilmiştir.

Anahtar Kelime:

The determination of uric acid in the presence of ascorbic acid and dopamine using [(1H1,2,4-triazole-3-ylimino)methyl]naphthalene-2-ol modified platinum electrode

Öz:

In this study, a modified electrode was developed via coating to platinum electrode (Pt) surface with a [(1H1,2,4-triazole-3-ylimino)methyl]naphthalene-2-ol (TMN-2-ol) film. Deposition of TMN-2-ol was performed by cyclic voltammetry scanning from -0.8 V to +2.0 V at a sweep rate of 100 mV s-1 for 40 cycles in 1×10-3 M TMN-2-ol solution. The modified electrode was characterized by cyclic voltammetry (CV), reflection adsorption infrared spectroscopy (RAIRS) and contact angle measurements (CAM). The electrocatalytic activity of the prepared and characterized modified electrode against UA in the presence of ascorbic acid (AA) and dopamine (DA) was determined by square wave voltammetry (SWV). The optimum working conditions were determined such as supporting electrolyte, pH. It was found that, the appropriate supporting electrolyte medium was 0.1 M pH 7.2 phosphate buffer (PBS). The calibration curve and limit of detection (LOD) were obtained in the range of 1.2310-6–1.5110-5 M and 1.56×10-8 M at the TMN-2-ol/Pt electrode, respectively. The effects of various anions and cations on the peak current of UA were investigated. The UA analysis was performed in human serum with low relative standart deviation values at the modified electrode by standard addition method.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Turan O, Tabanlıgil Calam T, uzun d, hasdemir e (2020). [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. , 2013 - 2022. 10.17341/gazimmfd.525552
Chicago	Turan Onder,Tabanlıgil Calam Tuğba,uzun demet,hasdemir erdoğan [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. (2020): 2013 - 2022. 10.17341/gazimmfd.525552
MLA	Turan Onder,Tabanlıgil Calam Tuğba,uzun demet,hasdemir erdoğan [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. , 2020, ss.2013 - 2022. 10.17341/gazimmfd.525552
AMA	Turan O,Tabanlıgil Calam T,uzun d,hasdemir e [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. . 2020; 2013 - 2022. 10.17341/gazimmfd.525552
Vancouver	Turan O,Tabanlıgil Calam T,uzun d,hasdemir e [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. . 2020; 2013 - 2022. 10.17341/gazimmfd.525552
IEEE	Turan O,Tabanlıgil Calam T,uzun d,hasdemir e "[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini." , ss.2013 - 2022, 2020. 10.17341/gazimmfd.525552
ISNAD	Turan, Onder vd. "[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini". (2020), 2013-2022. https://doi.org/10.17341/gazimmfd.525552

APA	Turan O, Tabanlıgil Calam T, uzun d, hasdemir e (2020). [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi, 35(4), 2013 - 2022. 10.17341/gazimmfd.525552
Chicago	Turan Onder,Tabanlıgil Calam Tuğba,uzun demet,hasdemir erdoğan [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi 35, no.4 (2020): 2013 - 2022. 10.17341/gazimmfd.525552
MLA	Turan Onder,Tabanlıgil Calam Tuğba,uzun demet,hasdemir erdoğan [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi, vol.35, no.4, 2020, ss.2013 - 2022. 10.17341/gazimmfd.525552
AMA	Turan O,Tabanlıgil Calam T,uzun d,hasdemir e [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi. 2020; 35(4): 2013 - 2022. 10.17341/gazimmfd.525552
Vancouver	Turan O,Tabanlıgil Calam T,uzun d,hasdemir e [(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini. Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi. 2020; 35(4): 2013 - 2022. 10.17341/gazimmfd.525552
IEEE	Turan O,Tabanlıgil Calam T,uzun d,hasdemir e "[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini." Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi, 35, ss.2013 - 2022, 2020. 10.17341/gazimmfd.525552
ISNAD	Turan, Onder vd. "[(1H-1,2,4-triazol-3-ylimin)metil]naftalen-2-ol modifiye platin elektrodu ile askorbik asit ve dopamin varlığında ürik asit tayini". Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi 35/4 (2020), 2013-2022. https://doi.org/10.17341/gazimmfd.525552