Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung

Amirov, Fahmin; KARA, MURAT; Duman, Salih; Ozkan, Berker; Ozluk, Yasemin; Toker, Alper; Cimenoglu, Berk; Erdoğdu, Eren; YILMAZBAYHAN, EMINE DILEK

doi:10.4274/balkanmedj.galenos.2020.2020.7.45

Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung

Berker ÖZKAN, (İstanbul Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Eren ERDOĞDU, (İstanbul Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Salih DUMAN, (İstanbul Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Fahmin AMIROV, (İstanbul Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Berk ÇİMENOĞLU, (İstanbul Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Yasemin ÖZLÜK, (İstanbul Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

Murat KARA, (İstanbul Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Dilek YILMAZBAYHAN, (İstanbul Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

Alper TOKER (West Virginia University Heart and Vascular Institute, Department of Cardiovascular and Thoracic Surgery, Morgantown, USA)

Balkan Medical Journal

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Yıl: 2021 Cilt: 38 Sayı: 2 Sayfa Aralığı: 104 - 110 Metin Dili: İngilizce DOI: 10.4274/balkanmedj.galenos.2020.2020.7.45 İndeks Tarihi: 13-05-2021

Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung

Öz:

Background: Pulmonary sarcomatoid carcinomas are very rare lungneoplasms, and no consensus exists regarding their optimal treatment.The prognosis of sarcomatoid carcinomas has been reported to be unfavorable compared with non-small-cell lung cancers; however, prognostic factors in patients undergoing surgery for sarcomatoid carcinomasremain unclear.Aims: To analyze clinicopathologic prognostic factors and survivaloutcomes in patients who underwent surgery for pulmonary sarcomatoid carcinoma.Study Design: Retrospective cross-sectional study.Methods: We designed a retrospective cross-sectional study in patientswho underwent surgery for pulmonary sarcomatoid carcinomas andstatistically analyzed the prognostic factors regarding clinicopathologicfeatures with respect to survival outcomes.Results: We had a total of 44 patients with sarcomatoid carcinoma whohad pulmonary resection. Sex distribution was 34 (77%) males and 10(22.7%) females, which was determined by declaration. The mean ageof patients was 57.3 ± 16 years with a median of 60 years. The 5-yearprogression-free survival and overall survival rates were 59% and 58%,respectively. The 5-year survival rates were significantly different fortumors > 5 cm (P = 0.044), tumorstatus (T) (P=0.016), lymph node status (N) (P=0.005), and pathologic tumor-node-metastasis (TNM) stage(P = 0.0001 ). However, histologic subtype (P = 0.628) and adjuvanttreatment (P = 0.804) did not have any significant effect on survival.Similarly, the significant prognostic factors in univariate analysis weretumor size (P = 0.085), T status (P = 0.005), N status (P = 0.028), andpathologic TNM stage (P = 0.0001). Multivariate analysis showed onlyT status (P = 0.058), N status (P = 0.018), and pathologic TNM stage(P = 0.019) as independent prognostic factors, with statistical power of87%, 43.1% and 21.2%.Conclusion: Surgery appears to be an optimal treatment with favorableoutcomes for patients with pulmonary sarcomatoid carcinoma. Patientswith small tumors at earlier stages are very likely to benefit from surgery, regardless of histologic subtype.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ozkan B, Erdoğdu E, Duman S, Amirov F, Cimenoglu B, Ozluk Y, KARA M, YILMAZBAYHAN E, Toker A (2021). Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. , 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
Chicago	Ozkan Berker,Erdoğdu Eren,Duman Salih,Amirov Fahmin,Cimenoglu Berk,Ozluk Yasemin,KARA MURAT,YILMAZBAYHAN EMINE DILEK,Toker Alper Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. (2021): 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
MLA	Ozkan Berker,Erdoğdu Eren,Duman Salih,Amirov Fahmin,Cimenoglu Berk,Ozluk Yasemin,KARA MURAT,YILMAZBAYHAN EMINE DILEK,Toker Alper Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. , 2021, ss.104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
AMA	Ozkan B,Erdoğdu E,Duman S,Amirov F,Cimenoglu B,Ozluk Y,KARA M,YILMAZBAYHAN E,Toker A Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. . 2021; 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
Vancouver	Ozkan B,Erdoğdu E,Duman S,Amirov F,Cimenoglu B,Ozluk Y,KARA M,YILMAZBAYHAN E,Toker A Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. . 2021; 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
IEEE	Ozkan B,Erdoğdu E,Duman S,Amirov F,Cimenoglu B,Ozluk Y,KARA M,YILMAZBAYHAN E,Toker A "Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung." , ss.104 - 110, 2021. 10.4274/balkanmedj.galenos.2020.2020.7.45
ISNAD	Ozkan, Berker vd. "Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung". (2021), 104-110. https://doi.org/10.4274/balkanmedj.galenos.2020.2020.7.45

APA	Ozkan B, Erdoğdu E, Duman S, Amirov F, Cimenoglu B, Ozluk Y, KARA M, YILMAZBAYHAN E, Toker A (2021). Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. Balkan Medical Journal, 38(2), 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
Chicago	Ozkan Berker,Erdoğdu Eren,Duman Salih,Amirov Fahmin,Cimenoglu Berk,Ozluk Yasemin,KARA MURAT,YILMAZBAYHAN EMINE DILEK,Toker Alper Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. Balkan Medical Journal 38, no.2 (2021): 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
MLA	Ozkan Berker,Erdoğdu Eren,Duman Salih,Amirov Fahmin,Cimenoglu Berk,Ozluk Yasemin,KARA MURAT,YILMAZBAYHAN EMINE DILEK,Toker Alper Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. Balkan Medical Journal, vol.38, no.2, 2021, ss.104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
AMA	Ozkan B,Erdoğdu E,Duman S,Amirov F,Cimenoglu B,Ozluk Y,KARA M,YILMAZBAYHAN E,Toker A Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. Balkan Medical Journal. 2021; 38(2): 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
Vancouver	Ozkan B,Erdoğdu E,Duman S,Amirov F,Cimenoglu B,Ozluk Y,KARA M,YILMAZBAYHAN E,Toker A Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung. Balkan Medical Journal. 2021; 38(2): 104 - 110. 10.4274/balkanmedj.galenos.2020.2020.7.45
IEEE	Ozkan B,Erdoğdu E,Duman S,Amirov F,Cimenoglu B,Ozluk Y,KARA M,YILMAZBAYHAN E,Toker A "Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung." Balkan Medical Journal, 38, ss.104 - 110, 2021. 10.4274/balkanmedj.galenos.2020.2020.7.45
ISNAD	Ozkan, Berker vd. "Prognostic factors in patients undergoing pulmonary resection for sarcomatoid carcinomas of the lung". Balkan Medical Journal 38/2 (2021), 104-110. https://doi.org/10.4274/balkanmedj.galenos.2020.2020.7.45