Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats

Semin GEDİKLİ, (Atatürk Üniversitesi, Veteriner Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Erzurum, Türkiye)
Elif ERBAŞ (Atatürk Üniversitesi, Veteriner Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Erzurum, Türkiye)
Kocatepe Veterinary Journal
20 2
Yıl: 2021 Cilt: 14 Sayı: 1 Sayfa Aralığı: 16 - 25 Metin Dili: İngilizce DOI: 10.30607/kvj.782356 İndeks Tarihi: 31-05-2021

Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats

Öz:
The current study aims to investigate the protective effects of naringin, one of the natural flavonoids, against inthe lungs damage caused by 5-FU, which is used chemotherapeutically. Thirty Sprague Dawley male rats weighing200-250 g were used in the study. The rats were randomly selected and divided into the control group, the 5-FUgroup and the NA+5-FU group. It was observed that 5-FU caused interstitial fibrosis and congestion in the lungtissues, thickening due to inflammatory cell infiltration in the inter-alveolar septum, peribronchial lymphoid tissuehyperplasia and epithelial cell shedding in the bronchioles. It was observed that naringin application alleviated thehistopathological findings in the lung and brought it closer to normal lung tissue histology. It was determined that5-FU administration increased Bax immunopositivity in the lungs, decreased Bcl-2 immunopositivity, andnaringin administration decreased Bax immunopositivity and increased Bcl-2 immunopositivity, similar to thecontrol group. It was found that TBARS and NO levels increased significantly with 5-FU administration, GSHlevel decreased significantly in the lung tissues compared to the control group, and these parameters approachedthe levels in the control group in the naringin group. All these findings suggest that naringin administration mayhave beneficial effects on 5-FU-induced lung injury.
Anahtar Kelime:

Ratlarda 5-Fluorouracil ile İndüklenen Akciğer Toksisitesi Üzerine Naringinin Koruyucu Etkileri

Öz:
Mevcut çalışmanın amacı; kemoterapötik olarak kullanılan 5-FU’nun akciğerlerde oluşturduğu hasara karşı doğal flavonoidlerden olan naringinin koruyucu etkilerini araştırmaktır. Çalışmada 200-250 g ağırlığında, 30 adet Sprague Dawley cinsi erkek rat kullanıldı. Ratlar rastgele seçilerek Kontrol grubu, 5-FU grubu ve NA+5-FU grubu olarak ayrıldı. 5-Fluorouracilin akciğer dokularında interstisyel fibrozis ve konjesyona, alveoller arası septumda yangısal hücre infiltrasyonuna bağlı kalınlaşma, peribronşiyal lenfoid doku hiperplazisi ile birlikte bronşiyollerde epitelyal hücre dökülmelerine neden olduğu gözlendi. Naringin uygulamasının ise akciğerdeki histopatolojik bulguları hafiflettiği ve normal akciğer doku histolojisine yaklaştırdığı gözlendi. 5-Fluorouracil uygulamasının akciğerlerdeki Bax immünpozitifliğini artırırken, Bcl-2 immünpozitifliğini azalttığı, naringin uygulamasının ise kontrol grubuna benzer şekilde Bax immünpozitifliğini azaltıp, Bcl-2 immünpozitifliğini artırdığı belirlendi. Akciğer dokularında kontrole kıyasla TBARS ve NO düzeylerinin 5-FU uygulaması ile anlamlı şekilde arttığı, GSH düzeyinin ise anlamlı şekilde azaldığı, naringin uygulanan grupta ise bu parametrelerin kontrol grubundaki düzeylere yaklaştığı tespit edildi. Tüm bu bulgular naringin uygulamasının, 5-FU kaynaklı akciğer hasarında faydalı etkiler gösterebileceğini düşündürmektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Gedikli S, ERBAŞ E (2021). Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. , 16 - 25. 10.30607/kvj.782356
Chicago Gedikli Semin,ERBAŞ ELİF Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. (2021): 16 - 25. 10.30607/kvj.782356
MLA Gedikli Semin,ERBAŞ ELİF Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. , 2021, ss.16 - 25. 10.30607/kvj.782356
AMA Gedikli S,ERBAŞ E Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. . 2021; 16 - 25. 10.30607/kvj.782356
Vancouver Gedikli S,ERBAŞ E Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. . 2021; 16 - 25. 10.30607/kvj.782356
IEEE Gedikli S,ERBAŞ E "Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats." , ss.16 - 25, 2021. 10.30607/kvj.782356
ISNAD Gedikli, Semin - ERBAŞ, ELİF. "Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats". (2021), 16-25. https://doi.org/10.30607/kvj.782356
APA Gedikli S, ERBAŞ E (2021). Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. Kocatepe Veterinary Journal, 14(1), 16 - 25. 10.30607/kvj.782356
Chicago Gedikli Semin,ERBAŞ ELİF Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. Kocatepe Veterinary Journal 14, no.1 (2021): 16 - 25. 10.30607/kvj.782356
MLA Gedikli Semin,ERBAŞ ELİF Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. Kocatepe Veterinary Journal, vol.14, no.1, 2021, ss.16 - 25. 10.30607/kvj.782356
AMA Gedikli S,ERBAŞ E Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. Kocatepe Veterinary Journal. 2021; 14(1): 16 - 25. 10.30607/kvj.782356
Vancouver Gedikli S,ERBAŞ E Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. Kocatepe Veterinary Journal. 2021; 14(1): 16 - 25. 10.30607/kvj.782356
IEEE Gedikli S,ERBAŞ E "Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats." Kocatepe Veterinary Journal, 14, ss.16 - 25, 2021. 10.30607/kvj.782356
ISNAD Gedikli, Semin - ERBAŞ, ELİF. "Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats". Kocatepe Veterinary Journal 14/1 (2021), 16-25. https://doi.org/10.30607/kvj.782356
Sayfa Oluşturulma Tarihi
23-04-2024 17:58

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