Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.

Nouran H. Abdel FATAH, (Mansoura University, Faculty of Pharmacy, Department of Pharmacognosy, Egypt)
Yhiya AMEN, (Mansoura University, Faculty of Pharmacy, Department of Pharmacognosy, Egypt)
Fatma M. Abdel BAR, (Mansoura University, Faculty of Pharmacy, Department of Pharmacognosy, Egypt)
Ahmed F. HALIM, (Mansoura University, Faculty of Pharmacy, Department of Pharmacognosy, Egypt)
Hassan-Elrady A. SAAD (Mansoura University, Faculty of Pharmacy, Department of Pharmacognosy, Egypt)
Records of Natural Products
2 0
Yıl: 2020 Cilt: 14 Sayı: 6 Sayfa Aralığı: 410 - 415 Metin Dili: İngilizce DOI: 10.25135/rnp.18.17.06.108 İndeks Tarihi: 21-06-2021

Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.

Öz:
Our main objective in the present study was investigation of potential antidiabetic and antioxidant compounds from the methanol extract of Lactuca serriola L. Phytochemical investigation allowed the isolation of seventeen known compounds and their structures were identified based on IR, 1D and 2D NMR techniques and mass spectrometry. Lupeol (1), β-sitosterol (2), taraxast-20-ene-3β,30-diol (3), glycerol monopalmitate (4) (2S,3S,4R,2`R,14E)-2-(2`-hydroxytetracosanoylamino)-14-octadecene-1,3,4-triol (5), lactucopicrin (6), daucosterol (7), (E)-p-coumaric acid (8), 11β,13-dihydrolactucin (9), 4-hydroxybenzoic acid (10), protocatechuic acid (11), kaempferol (12), quercetin (13), lactuside A (14), luteolin-7-O-β-D glucoside (15), lactuside B (16) and cichorioside B (17) were isolated from the species. The antioxidant activity was evaluated using ABTS, DPPH radical scavenging and FRAP assays. The ethyl acetate fraction of the aerial parts of species showed remarkable α-glucosidase inhibitory activity (IC50, 9.16±0.17 µg/mL) and antioxidant activity among the tested fractions. The in vitro α-glucosidase inhibitory assay is reported in this study for the first time for L. serriola L. The results strongly suggest that L. serriolaL. can be used as a potential good natural remedy targeting oxidative stress-related diabetes mellitus.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Hussein N, Amen Y, BAR F, Halim A, SAAd H (2020). Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. , 410 - 415. 10.25135/rnp.18.17.06.108
Chicago Hussein Nouran,Amen Yhiya,BAR Fatma M. Abdel,Halim Ahmed,SAAd Hassan-Elrady Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. (2020): 410 - 415. 10.25135/rnp.18.17.06.108
MLA Hussein Nouran,Amen Yhiya,BAR Fatma M. Abdel,Halim Ahmed,SAAd Hassan-Elrady Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. , 2020, ss.410 - 415. 10.25135/rnp.18.17.06.108
AMA Hussein N,Amen Y,BAR F,Halim A,SAAd H Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. . 2020; 410 - 415. 10.25135/rnp.18.17.06.108
Vancouver Hussein N,Amen Y,BAR F,Halim A,SAAd H Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. . 2020; 410 - 415. 10.25135/rnp.18.17.06.108
IEEE Hussein N,Amen Y,BAR F,Halim A,SAAd H "Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.." , ss.410 - 415, 2020. 10.25135/rnp.18.17.06.108
ISNAD Hussein, Nouran vd. "Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.". (2020), 410-415. https://doi.org/10.25135/rnp.18.17.06.108
APA Hussein N, Amen Y, BAR F, Halim A, SAAd H (2020). Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. Records of Natural Products, 14(6), 410 - 415. 10.25135/rnp.18.17.06.108
Chicago Hussein Nouran,Amen Yhiya,BAR Fatma M. Abdel,Halim Ahmed,SAAd Hassan-Elrady Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. Records of Natural Products 14, no.6 (2020): 410 - 415. 10.25135/rnp.18.17.06.108
MLA Hussein Nouran,Amen Yhiya,BAR Fatma M. Abdel,Halim Ahmed,SAAd Hassan-Elrady Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. Records of Natural Products, vol.14, no.6, 2020, ss.410 - 415. 10.25135/rnp.18.17.06.108
AMA Hussein N,Amen Y,BAR F,Halim A,SAAd H Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. Records of Natural Products. 2020; 14(6): 410 - 415. 10.25135/rnp.18.17.06.108
Vancouver Hussein N,Amen Y,BAR F,Halim A,SAAd H Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.. Records of Natural Products. 2020; 14(6): 410 - 415. 10.25135/rnp.18.17.06.108
IEEE Hussein N,Amen Y,BAR F,Halim A,SAAd H "Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.." Records of Natural Products, 14, ss.410 - 415, 2020. 10.25135/rnp.18.17.06.108
ISNAD Hussein, Nouran vd. "Antioxidants and α-Glucosidase Inhibitors fromLactuca serriola L.". Records of Natural Products 14/6 (2020), 410-415. https://doi.org/10.25135/rnp.18.17.06.108
Sayfa Oluşturulma Tarihi
23-04-2024 18:32

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