Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions

OZSOY, KEREM MAZHAR; GÜZEL, Aslan; Oktay, Kadir; Cetinalp, Nuri Eralp; Erman, Tahsin

doi:10.5152/j.aott.2021.18372

Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions

Kadir OKTAY, (Çukurova Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı, Adana, Türkiye)

Kerem Mazhar ÖZSOY, (Çukurova Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı, Adana, Türkiye)

Nuri Eralp ÇETİNALP, (Çukurova Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı, Adana, Türkiye)

Tahsin ERMAN, (Çukurova Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı, Adana, Türkiye)

Aslan GÜZEL (Bahçeşehir Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Acta Orthopaedica et Traumatologica Turcica

2 0

Yıl: 2021 Cilt: 55 Sayı: 1 Sayfa Aralığı: 48 - 52 Metin Dili: İngilizce DOI: 10.5152/j.aott.2021.18372 İndeks Tarihi: 30-09-2021

Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions

Öz:

Objective: This study aimed to determine the efficacy of prophylactic use of vancomycin powder against surgical site infections in patientswith high-risk conditions who underwent posterior spinal instrumentation.Methods: Data obtained from 209 patients who underwent posterior spinal instrumentation at a single institution from 2014 to 2017 were retrospectively reviewed. Patients were then divided into two groups: control group, including 107 patients (61 females, 46 males; mean age=54years; age range=16-85 years), and treatment group, including 102 patients (63 females, 39 males; mean age=53 years; age range=14-90 years).All patients received the same standard prophylactic antibiotic regimen. In addition to the prophylactic antibiotic, vancomycin powder wasapplied locally to the surgical site in the treatment group. All patients were followed up for at least 90 days postoperatively. Infections werecategorized as superficial and deep infections. Subgroup analysis of high-risk patients (Syrian refugees) was also performed.Results: The infection rates were 1.96% (two patients) in the treatment group and 6.54% (seven patients) in the control group. A significantdecrease in the infection rates was observed with local vancomycin powder application. Advanced age (>46 years) and prolonged surgicalduration (>140 min) were found to be the main risk factors for surgical site infections (p=0.004 and p=0.028, respectively). The infectionrates were 3.22% and 8.11% in the treatment and control groups of refugees, respectively. There were three superficial and four deep infections in the control group and one superficial and one deep infection in the treatment group. A dominance of staphylococcus infectionswas observed in the control group, whereas no significant dominance was observed in the treatment group. Three patients in the controlgroup and one patient in the treatment group received implant removal.Conclusion: Evidence from this study has revealed that local application of vancomycin powder reduces the rate of surgical site infectionsafter instrumented spinal surgery. The benefit of vancomycin application may be most appreciated in higher risk populations or in clinicswith high baseline rates of infection.Level of Evidence: Level III, Therapeutic Study

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	Oktay K, OZSOY K, Cetinalp N, Erman T, GÜZEL A (2021). Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. , 48 - 52. 10.5152/j.aott.2021.18372
Chicago	Oktay Kadir,OZSOY KEREM MAZHAR,Cetinalp Nuri Eralp,Erman Tahsin,GÜZEL Aslan Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. (2021): 48 - 52. 10.5152/j.aott.2021.18372
MLA	Oktay Kadir,OZSOY KEREM MAZHAR,Cetinalp Nuri Eralp,Erman Tahsin,GÜZEL Aslan Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. , 2021, ss.48 - 52. 10.5152/j.aott.2021.18372
AMA	Oktay K,OZSOY K,Cetinalp N,Erman T,GÜZEL A Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. . 2021; 48 - 52. 10.5152/j.aott.2021.18372
Vancouver	Oktay K,OZSOY K,Cetinalp N,Erman T,GÜZEL A Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. . 2021; 48 - 52. 10.5152/j.aott.2021.18372
IEEE	Oktay K,OZSOY K,Cetinalp N,Erman T,GÜZEL A "Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions." , ss.48 - 52, 2021. 10.5152/j.aott.2021.18372
ISNAD	Oktay, Kadir vd. "Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions". (2021), 48-52. https://doi.org/10.5152/j.aott.2021.18372

APA	Oktay K, OZSOY K, Cetinalp N, Erman T, GÜZEL A (2021). Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. Acta Orthopaedica et Traumatologica Turcica, 55(1), 48 - 52. 10.5152/j.aott.2021.18372
Chicago	Oktay Kadir,OZSOY KEREM MAZHAR,Cetinalp Nuri Eralp,Erman Tahsin,GÜZEL Aslan Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. Acta Orthopaedica et Traumatologica Turcica 55, no.1 (2021): 48 - 52. 10.5152/j.aott.2021.18372
MLA	Oktay Kadir,OZSOY KEREM MAZHAR,Cetinalp Nuri Eralp,Erman Tahsin,GÜZEL Aslan Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. Acta Orthopaedica et Traumatologica Turcica, vol.55, no.1, 2021, ss.48 - 52. 10.5152/j.aott.2021.18372
AMA	Oktay K,OZSOY K,Cetinalp N,Erman T,GÜZEL A Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. Acta Orthopaedica et Traumatologica Turcica. 2021; 55(1): 48 - 52. 10.5152/j.aott.2021.18372
Vancouver	Oktay K,OZSOY K,Cetinalp N,Erman T,GÜZEL A Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions. Acta Orthopaedica et Traumatologica Turcica. 2021; 55(1): 48 - 52. 10.5152/j.aott.2021.18372
IEEE	Oktay K,OZSOY K,Cetinalp N,Erman T,GÜZEL A "Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions." Acta Orthopaedica et Traumatologica Turcica, 55, ss.48 - 52, 2021. 10.5152/j.aott.2021.18372
ISNAD	Oktay, Kadir vd. "Efficacy of prophylactic application of vancomycin powder in preventing surgical site infections after instrumented spinal surgery: A retrospective analysis of patients with high-risk conditions". Acta Orthopaedica et Traumatologica Turcica 55/1 (2021), 48-52. https://doi.org/10.5152/j.aott.2021.18372