Objective According to cholera example to investigate Republi can period of Turkey's epidemic measures and to pro vide the information obtained about them. Materials and Methods Within the scope of this study, publications related tothe subject were read, the Turkish State Archives Re public Archive Catalog was scanned, the original arc hive documents were examined and the results in ac cordance with the chronological order were reached.Results Turkey had taken the necessary measures to strugglewith the epidemics and prevent the outbreak. The firstarchive document examined in this context is 1924dated and the last document is 1973 dated. The num ber of documents found is 38. Measures were takenupon the occurrence of cholera cases. In addition, amechanism has been established for reporting the di sease. The measures have been taken especially inborder crossings and transportation issues in order toprevent outbreaks started abroad. Efforts have beenmade to produce and back up cholera vaccine. Howe ver, vaccines have been sent to countries what strugg le with epidemics. In 1970, with the cholera epidemicthat took place in Sagmalcilar-Istanbul was struggled.Various measures have been taken to struggle chole ra after this epidemic. In the same year, it is forbiddento go on the hajj by road. A protocol has been signedwith Bulgaria for the fight against cholera.Conclusion According to the archive documents examined, ithas been observed that measures such as closingborders and stopping sea and air transportation aretaken regarding outbreaks seen abroad. Also, impor tant works have been accomplished in the fields ofvaccination, hygiene, isolation and treatment. Whennecessary, final and radical decisions were made. Allof these are very similar to the current epidemics andespecially the measures taken against the new typeof coronavirus (COVID-19) pandemic. We think thatthe successes or deficiencies provided in the past willbe a good guide in combating the outbreaks that willoccur today and in the future.