Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü

TOPRAK, SELIN FULYA; Sozer Tokdemir, Selcuk; Toprak, Fatih

doi:10.26650/experimed.2021.831169

Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü

Fatih TOPRAK, (Sağlık Bilimleri Üniversitesi, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Selin Fulya TOPRAK, (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye)

Selçuk Sözer TOKDEMİR (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye)

EXPERIMED

2 2

Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 57 - 66 Metin Dili: Türkçe DOI: 10.26650/experimed.2021.831169 İndeks Tarihi: 03-12-2021

Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü

Öz:

Nörogenez, nöral kök hücrelerin (NKH) bölünme, göç etme ve farklılaşma süreçlerinin bütününü oluşturmaktadır. Lateral ventrikülün subventriküler bölgesi (SVZ) ve hipokampus dentat girus (DG)’daki subgranüler bölge (SGZ) olmak üzere iki farklı nişte gerçekleşmektedir. Nörotrofik faktörler, NKH ve nöral progenitor hücrelerin migrasyon, proliferasyon ve farklılaşmasında rol oynar. Ayrıca, NKH’lerin hasarlı dokuda, nöral hücrelerin yeniden yapılanması, nöral plastisite ve anjiogenezi düzenleyici etkileri olduğu gösterilmiştir. Yetişkin nörogenezinde ise nörotrofik faktör kombinasyonlarının serebrovasküler, nörodejeneratif, onkolojik hastalıklar ve travma sonrası oluşan inflamatuvar hasar tedavisinde önemli rolü olduğu bilinmektedir. Bu derlemede, nörotrofik faktörlerin NKH’ler üzerindeki modüle edici etkisi ve potansiyel terapötik uygulamalarında preklinik ve klinik çalışmaları içeren güncel literatürler biraraya getirilmiştir. Bu alanda çalışma yapan araştırmacı ve hekimlere fayda sağlayacak güncel bilgiler içermektedir.

Anahtar Kelime:

The Role of Growth Factors in Adult Neurogenesis and Neurodegenerative Diseases

Öz:

Neurogenesis is the combined processes of division, migration and differentiation of neural stem cells (NSCs). The two different locations: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) in the hippocampus dentate gyrus (DG), provide a niche environment for neurogenesis. Neurotrophic factors have roles on migration, proliferation and differentiation of NSC and neural progenitor cells. Studies have shown that NSCs have regulatory effects on neural cell rearrangement, neural plasticity and angiogenesis in damaged tissue. In adult neurogenesis, combinations of neurotrophic factors play an important role in the treatment of cerebrovascular, neurodegenerative, oncological diseases and post-traumatic inflammatory damage. In this review, current literature including pre-clinical and clinical studies for the modulating effect of neurotrophic factors on NSCs and their potential therapeutic treatment applications are brought together. It contains up-to-date information that would be beneficial for researchers and physicians working in this field.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Toprak F, TOPRAK S, Sozer Tokdemir S (2021). Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. , 57 - 66. 10.26650/experimed.2021.831169
Chicago	Toprak Fatih,TOPRAK SELIN FULYA,Sozer Tokdemir Selcuk Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. (2021): 57 - 66. 10.26650/experimed.2021.831169
MLA	Toprak Fatih,TOPRAK SELIN FULYA,Sozer Tokdemir Selcuk Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. , 2021, ss.57 - 66. 10.26650/experimed.2021.831169
AMA	Toprak F,TOPRAK S,Sozer Tokdemir S Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. . 2021; 57 - 66. 10.26650/experimed.2021.831169
Vancouver	Toprak F,TOPRAK S,Sozer Tokdemir S Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. . 2021; 57 - 66. 10.26650/experimed.2021.831169
IEEE	Toprak F,TOPRAK S,Sozer Tokdemir S "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü." , ss.57 - 66, 2021. 10.26650/experimed.2021.831169
ISNAD	Toprak, Fatih vd. "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü". (2021), 57-66. https://doi.org/10.26650/experimed.2021.831169

APA	Toprak F, TOPRAK S, Sozer Tokdemir S (2021). Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. EXPERIMED, 11(1), 57 - 66. 10.26650/experimed.2021.831169
Chicago	Toprak Fatih,TOPRAK SELIN FULYA,Sozer Tokdemir Selcuk Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. EXPERIMED 11, no.1 (2021): 57 - 66. 10.26650/experimed.2021.831169
MLA	Toprak Fatih,TOPRAK SELIN FULYA,Sozer Tokdemir Selcuk Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. EXPERIMED, vol.11, no.1, 2021, ss.57 - 66. 10.26650/experimed.2021.831169
AMA	Toprak F,TOPRAK S,Sozer Tokdemir S Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. EXPERIMED. 2021; 11(1): 57 - 66. 10.26650/experimed.2021.831169
Vancouver	Toprak F,TOPRAK S,Sozer Tokdemir S Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü. EXPERIMED. 2021; 11(1): 57 - 66. 10.26650/experimed.2021.831169
IEEE	Toprak F,TOPRAK S,Sozer Tokdemir S "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü." EXPERIMED, 11, ss.57 - 66, 2021. 10.26650/experimed.2021.831169
ISNAD	Toprak, Fatih vd. "Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü". EXPERIMED 11/1 (2021), 57-66. https://doi.org/10.26650/experimed.2021.831169