Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases

ERDEM, YUNUS; Uzerk Kibar, Muge; Kütahya, Berranur; ERDEVİR, MEHMET; İŞ, FATMA; Saglam, Arzu; KOC, Neriman Sila; Yilmaz, Rahmi; YILDIRIM, Tolga

doi:10.3906/sag-2102-13

Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases

Tolga YILDIRIM, (Hacettepe Üniversitesi, Nefroloji Anabilim Dalı, Intern Tıp Fakültesi, Ankara, Türkiye)

Berranur KÜTAHYA, (Hacettepe Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Fatma İŞ, (Hacettepe Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Mehmet ERDEVİR, (Hacettepe Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Müge ÜZERK KİBAR, (Hacettepe Üniversitesi, Nefroloji Anabilim Dalı, Intern Tıp Fakültesi, Ankara, Türkiye)

Neriman Sıla KOÇ, (Hacettepe Üniversitesi, Nefroloji Anabilim Dalı, Intern Tıp Fakültesi, Ankara, Türkiye)

Arzu AYHAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Rahmi YILMAZ, (Hacettepe Üniversitesi, Nefroloji Anabilim Dalı, Intern Tıp Fakültesi, Ankara, Türkiye)

Yunus ERDEM (Hacettepe Üniversitesi, Nefroloji Anabilim Dalı, Intern Tıp Fakültesi, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2021 Cilt: 51 Sayı: 5 Sayfa Aralığı: 2364 - 2368 Metin Dili: İngilizce DOI: 10.3906/sag-2102-13 İndeks Tarihi: 06-01-2022

Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases

Öz:

Background/aim: Compared to healthy controls, mean platelet volume (MPV) is frequently higher in patients with Familial Mediterranean fever (FMF) but lower in AA amyloidosis patients. The reason for the difference in MPV levels in FMF patients with and without AA amyloidosis is unclear. The aim of the study was to determine whether low MPV is unique to AA amyloidosis or MPV is similarly low in all glomerular diseases as a result of proteinuria and/or renal dysfunction. Materials and methods: We compared pre-biopsy MPV levels of patients with AA amyloidosis secondary to FMF, to MPV levels of patients with membranous glomerulonephritis, focal segmental glomerulosclerosis (FSGS) and IgA nephropathy that all present with proteinuria and renal dysfunction. Results: 703 patients (411 male, 292 female) were included in the study. Mean age was 42.6  14.3 years. There were 124 patients with AA amyloidosis, 224 patients with IgA nephropathy, 188 patients with membranous glomerulonephritis, and 167 patients with FSGS. Patients with AA amyloidosis had lower MPV levels compared to patients without AA amyloidosis (7.9  1.2 fL vs. 8.2  0.9 fL respectively, p = 0.008). Patients with AA amyloidosis had significantly lower MPV compared to patients with each of the other diagnoses. Independent predictors of MPV were platelet count (β = –0.321, p < 0.001) and CRP (β = – 0.134, p < 0.03). Conclusion: This study is the largest study of MPV in patients with biopsy proven AA amyloidosis and confirms previous studies reporting low MPV in AA amyloidosis. This study indicates that low MPV in AA amyloidosis cannot be explained with proteinuria and renal dysfunction.Key words: AA amyloidosis, familial Mediterranean fever, glomerulonephritis, mean platelet volume

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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIRIM T, Kütahya B, İŞ F, ERDEVİR M, Uzerk Kibar M, KOC N, Saglam A, Yilmaz R, ERDEM Y (2021). Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. , 2364 - 2368. 10.3906/sag-2102-13
Chicago	YILDIRIM Tolga,Kütahya Berranur,İŞ FATMA,ERDEVİR MEHMET,Uzerk Kibar Muge,KOC Neriman Sila,Saglam Arzu,Yilmaz Rahmi,ERDEM YUNUS Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. (2021): 2364 - 2368. 10.3906/sag-2102-13
MLA	YILDIRIM Tolga,Kütahya Berranur,İŞ FATMA,ERDEVİR MEHMET,Uzerk Kibar Muge,KOC Neriman Sila,Saglam Arzu,Yilmaz Rahmi,ERDEM YUNUS Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. , 2021, ss.2364 - 2368. 10.3906/sag-2102-13
AMA	YILDIRIM T,Kütahya B,İŞ F,ERDEVİR M,Uzerk Kibar M,KOC N,Saglam A,Yilmaz R,ERDEM Y Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. . 2021; 2364 - 2368. 10.3906/sag-2102-13
Vancouver	YILDIRIM T,Kütahya B,İŞ F,ERDEVİR M,Uzerk Kibar M,KOC N,Saglam A,Yilmaz R,ERDEM Y Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. . 2021; 2364 - 2368. 10.3906/sag-2102-13
IEEE	YILDIRIM T,Kütahya B,İŞ F,ERDEVİR M,Uzerk Kibar M,KOC N,Saglam A,Yilmaz R,ERDEM Y "Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases." , ss.2364 - 2368, 2021. 10.3906/sag-2102-13
ISNAD	YILDIRIM, Tolga vd. "Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases". (2021), 2364-2368. https://doi.org/10.3906/sag-2102-13

APA	YILDIRIM T, Kütahya B, İŞ F, ERDEVİR M, Uzerk Kibar M, KOC N, Saglam A, Yilmaz R, ERDEM Y (2021). Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. Turkish Journal of Medical Sciences, 51(5), 2364 - 2368. 10.3906/sag-2102-13
Chicago	YILDIRIM Tolga,Kütahya Berranur,İŞ FATMA,ERDEVİR MEHMET,Uzerk Kibar Muge,KOC Neriman Sila,Saglam Arzu,Yilmaz Rahmi,ERDEM YUNUS Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. Turkish Journal of Medical Sciences 51, no.5 (2021): 2364 - 2368. 10.3906/sag-2102-13
MLA	YILDIRIM Tolga,Kütahya Berranur,İŞ FATMA,ERDEVİR MEHMET,Uzerk Kibar Muge,KOC Neriman Sila,Saglam Arzu,Yilmaz Rahmi,ERDEM YUNUS Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. Turkish Journal of Medical Sciences, vol.51, no.5, 2021, ss.2364 - 2368. 10.3906/sag-2102-13
AMA	YILDIRIM T,Kütahya B,İŞ F,ERDEVİR M,Uzerk Kibar M,KOC N,Saglam A,Yilmaz R,ERDEM Y Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. Turkish Journal of Medical Sciences. 2021; 51(5): 2364 - 2368. 10.3906/sag-2102-13
Vancouver	YILDIRIM T,Kütahya B,İŞ F,ERDEVİR M,Uzerk Kibar M,KOC N,Saglam A,Yilmaz R,ERDEM Y Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases. Turkish Journal of Medical Sciences. 2021; 51(5): 2364 - 2368. 10.3906/sag-2102-13
IEEE	YILDIRIM T,Kütahya B,İŞ F,ERDEVİR M,Uzerk Kibar M,KOC N,Saglam A,Yilmaz R,ERDEM Y "Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases." Turkish Journal of Medical Sciences, 51, ss.2364 - 2368, 2021. 10.3906/sag-2102-13
ISNAD	YILDIRIM, Tolga vd. "Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases". Turkish Journal of Medical Sciences 51/5 (2021), 2364-2368. https://doi.org/10.3906/sag-2102-13