The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens

ÜNAL, Egemen; Onay, Aslıhan

doi:10.3906/sag-2012-55

The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens

Aslıhan ONAY, (TOBB ETÜ Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye)

Egemen ÜNAL (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Radyoloji Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Medical Sciences

2 0

Yıl: 2021 Cilt: 51 Sayı: 4 Sayfa Aralığı: 1940 - 1952 Metin Dili: İngilizce DOI: 10.3906/sag-2012-55 İndeks Tarihi: 13-01-2022

The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens

Öz:

Backround/aim: In prostate cancer, extraprostatic extension (EPE) is an unfavorable prognostic factor, and the grade of EPE is correlated with the prognosis. This study aims to evaluate the utility of length of capsular contact (LCC ) in predicting the grade of EPE by correlating the measurements from MRI images and the measurements performed from radical prostatectomy specimens. Materials and methods: MR images and specimens of 110 tumors are analyzed retrospectively. The specimens are used as reference to validate the presence of EPE and to measure the ground truth LCC. MR images are evaluated by two radiologists to identify the presence of EPE and to predict the LCC indirectly. Reliability, accuracy, sensitivity, and specificity of the evaluations are analyzed in comparison with the findings obtained from the specimens. Results: In detection of EPE existence, the radiologists achieve almost the same performance (all AUCs = 0.73) with optimal cut-off values lead to moderate sensitivity and specificity pairs (For cut-off = 15.8 mm; Se = 0.69, Sp = 0.68 and for cut-off of 14.5 mm: Se = 0.77, Sp = 0.62). In distinguishing high-grade EPE from low-grade EPE, the radiologists accomplish very similar performances (AUCs = 0.73 and 0.72) Optimal thresholds of 20.0 mm and 18.5 mm for the readers retrospectively reveal medium sensitivity and specificity pairs (Se = 0.64, Sp = 0.67; Se = 0.64, Sp = 0.67). Conclusion: Consistent LCC estimates can be obtained from MR images providing a beneficial metric for detecting the existence of EPE and for discriminating the grades of EPE.Key words: Prostate cancer, extraprostatic extension, length of capsular contact, tumor grading, multi-parametric magnetic resonance imaging

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Onay A, ÜNAL E (2021). The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. , 1940 - 1952. 10.3906/sag-2012-55
Chicago	Onay Aslıhan,ÜNAL Egemen The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. (2021): 1940 - 1952. 10.3906/sag-2012-55
MLA	Onay Aslıhan,ÜNAL Egemen The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. , 2021, ss.1940 - 1952. 10.3906/sag-2012-55
AMA	Onay A,ÜNAL E The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. . 2021; 1940 - 1952. 10.3906/sag-2012-55
Vancouver	Onay A,ÜNAL E The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. . 2021; 1940 - 1952. 10.3906/sag-2012-55
IEEE	Onay A,ÜNAL E "The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens." , ss.1940 - 1952, 2021. 10.3906/sag-2012-55
ISNAD	Onay, Aslıhan - ÜNAL, Egemen. "The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens". (2021), 1940-1952. https://doi.org/10.3906/sag-2012-55

APA	Onay A, ÜNAL E (2021). The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. Turkish Journal of Medical Sciences, 51(4), 1940 - 1952. 10.3906/sag-2012-55
Chicago	Onay Aslıhan,ÜNAL Egemen The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. Turkish Journal of Medical Sciences 51, no.4 (2021): 1940 - 1952. 10.3906/sag-2012-55
MLA	Onay Aslıhan,ÜNAL Egemen The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. Turkish Journal of Medical Sciences, vol.51, no.4, 2021, ss.1940 - 1952. 10.3906/sag-2012-55
AMA	Onay A,ÜNAL E The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. Turkish Journal of Medical Sciences. 2021; 51(4): 1940 - 1952. 10.3906/sag-2012-55
Vancouver	Onay A,ÜNAL E The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens. Turkish Journal of Medical Sciences. 2021; 51(4): 1940 - 1952. 10.3906/sag-2012-55
IEEE	Onay A,ÜNAL E "The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens." Turkish Journal of Medical Sciences, 51, ss.1940 - 1952, 2021. 10.3906/sag-2012-55
ISNAD	Onay, Aslıhan - ÜNAL, Egemen. "The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens". Turkish Journal of Medical Sciences 51/4 (2021), 1940-1952. https://doi.org/10.3906/sag-2012-55