Yıl: 2021 Cilt: 8 Sayı: 4 Sayfa Aralığı: 371 - 376 Metin Dili: İngilizce DOI: 10.14744/nci.2020.23921 İndeks Tarihi: 21-01-2022

Relationship between heart rate recovery index and erectile dysfunction

Öz:
OBJECTIVE: Heart rate recovery (HRR) is a cardiac parameter that can be used to evaluate autonomic nervous system (ANS) function problems. We examined the possible relationship between erectile dysfunction (ED) and HRR which is a clinical condition associated with ANS dysfunction. METHODS: Seventy-six male patients that were examined with an exercise stress test and completed the International Index of Erectile Function Questionnaire Form (IIEF-5) were included in the study. The patients were divided into two groups as those with a normal HRR index (≥12, n=42) and those with an abnormal HRR index (<12, n=34). Then, statistical analyses were conducted to evaluate the correlations between ED and HRR. RESULTS: There were no differences between the groups in terms of risk factors, such as laboratory findings, age, BMI, hypertension, and smoking. However, in the group with an abnormal HRR index, the IIEF-5 score was significantly lower than the other group (11.2±4.2 vs. 20.3±4.6, p<0.001). A statistically significant positive correlation was observed between the IIEF-5 score and HRR index (r=0.702, p<0.001). In addition, the presence of diabetes mellitus and HRR index was independent risk factors for lowering the IIEF-5 score. CONCLUSION: The HRR index can be considered as an independent predictor of ED since a reduced value, which is associated with cardiovascular mortality and also causes ANS dysfunction.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med 2007;120:151–7.
  • 2. Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med 2011;171:1797–803.
  • 3. Jackson G. The importance of risk factor reduction in erectile dysfunction. Curr Urol Rep 2007;8:463–6.
  • 4. Ralph DJ. Normal erectile function. Clin Cornerstone 2005;7:13–8.
  • 5. Jung J, Jo HW, Kwon H, Jeong NY. Clinical neuroanatomy and neurotransmitter-mediated regulation of penile erection. Int Neurourol J 2014;18:58–62.
  • 6. Lauer MS. Autonomic function and prognosis. Cleve Clin J Med 2009;76 Suppl 2:S18–22.
  • 7. Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H, et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 1994;24:1529–35.
  • 8. Sears CE, Choate JK, Paterson DJ. Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation. J Appl Physiol (1985) 1998;84:1596–603.
  • 9. Ushijima A, Fukuma N, Kato Y, Aisu N, Mizuno K. Sympathetic excitation during exercise as a cause of attenuated heart rate recovery in patients with myocardial infarction. J Nippon Med Sch 2009;76:76–83.
  • 10. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heartrate recovery immediately after exercise as a predictor of mortality. N Engl J Med 1999;341:1351–7.
  • 11. Perret-Guillaume C, Joly L, Benetos A. Heart rate as a risk factor for cardiovascular disease. Prog Cardiovasc Dis 2009;52:6–10.
  • 12. Guazzi M, Myers J, Peberdy MA, Bensimhon D, Chase P, Arena R. Heart rate recovery predicts sudden cardiac death in heart failure. Int J Cardiol 2010;144:121–3.
  • 13. Mensink GB, Ziese T, Kok FJ. Benefits of leisure-time physical activity on the cardiovascular risk profile at older age. Int J Epidemiol 1999;28:659–66.
  • 14. Youn HJ, Park CS, Moon KW, Oh YS, Chung WS, Kim JH, et al. Relation between Duke treadmill score and coronary flow reserve using transesophageal Doppler echocardiography in patients with microvascular angina. Int J Cardiol 2005;98:403–8.
  • 15. Giuliano F, Rampin O. Neural control of erection. Physiol Behav 2004;83:189–201.
  • 16. Vivekananthan DP, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol 2003;42:831–8.
  • 17. Kannankeril PJ, Le FK, Kadish AH, Goldberger JJ. Parasympathetic effects on heart rate recovery after exercise. J Investig Med 2004;52:394– 401.
  • 18. Okutucu S, Karakulak UN, Aytemir K, Oto A. Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function. Expert Rev Cardiovasc Ther 2011;9:1417–30.
  • 19. Jae SY, Carnethon MR, Heffernan KS, Fernhall B, Lee MK, Park WH. Heart rate recovery after exercise and incidence of type 2 diabetes in men. Clin Auton Res 2009;19:189–92.
  • 20. Cheitlin MD. Sexual activity and cardiac risk. Am J Cardiol 2005;96:24M–8M.
  • 21. Chen CJ, Kuo TB, Tseng YJ, Yang CC. Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction. Clin Neurophysiol 2009;120:348–52.
  • 22. Lee JY, Joo KJ, Kim JT, Cho ST, Cho DS, Won YY, et al. Heart rate variability in men with erectile dysfunction. Int Neurourol J 2011;15:87– 91.
  • 23. Kałka D, Domagała Z, Dworak J, Womperski K, Rusiecki L, Marciniak W, et al. Association between physical exercise and quality of erection in men with ischaemic heart disease and erectile dysfunction subjected to physical training. Kardiol Pol 2013;71:573–80.
  • 24. Kałka D, Domagała Z, Rusiecki L, Karpiński Ł, Gebala J, Kolęda P, et al. Heart rate recovery, cardiac rehabilitation and erectile dysfunction in males with ischaemic heart disease. Anatol J Cardiol 2016;16:256–63.
APA Erbay G, Ceyhun G (2021). Relationship between heart rate recovery index and erectile dysfunction. , 371 - 376. 10.14744/nci.2020.23921
Chicago Erbay Güven,Ceyhun Gökhan Relationship between heart rate recovery index and erectile dysfunction. (2021): 371 - 376. 10.14744/nci.2020.23921
MLA Erbay Güven,Ceyhun Gökhan Relationship between heart rate recovery index and erectile dysfunction. , 2021, ss.371 - 376. 10.14744/nci.2020.23921
AMA Erbay G,Ceyhun G Relationship between heart rate recovery index and erectile dysfunction. . 2021; 371 - 376. 10.14744/nci.2020.23921
Vancouver Erbay G,Ceyhun G Relationship between heart rate recovery index and erectile dysfunction. . 2021; 371 - 376. 10.14744/nci.2020.23921
IEEE Erbay G,Ceyhun G "Relationship between heart rate recovery index and erectile dysfunction." , ss.371 - 376, 2021. 10.14744/nci.2020.23921
ISNAD Erbay, Güven - Ceyhun, Gökhan. "Relationship between heart rate recovery index and erectile dysfunction". (2021), 371-376. https://doi.org/10.14744/nci.2020.23921
APA Erbay G, Ceyhun G (2021). Relationship between heart rate recovery index and erectile dysfunction. İstanbul Kuzey Klinikleri, 8(4), 371 - 376. 10.14744/nci.2020.23921
Chicago Erbay Güven,Ceyhun Gökhan Relationship between heart rate recovery index and erectile dysfunction. İstanbul Kuzey Klinikleri 8, no.4 (2021): 371 - 376. 10.14744/nci.2020.23921
MLA Erbay Güven,Ceyhun Gökhan Relationship between heart rate recovery index and erectile dysfunction. İstanbul Kuzey Klinikleri, vol.8, no.4, 2021, ss.371 - 376. 10.14744/nci.2020.23921
AMA Erbay G,Ceyhun G Relationship between heart rate recovery index and erectile dysfunction. İstanbul Kuzey Klinikleri. 2021; 8(4): 371 - 376. 10.14744/nci.2020.23921
Vancouver Erbay G,Ceyhun G Relationship between heart rate recovery index and erectile dysfunction. İstanbul Kuzey Klinikleri. 2021; 8(4): 371 - 376. 10.14744/nci.2020.23921
IEEE Erbay G,Ceyhun G "Relationship between heart rate recovery index and erectile dysfunction." İstanbul Kuzey Klinikleri, 8, ss.371 - 376, 2021. 10.14744/nci.2020.23921
ISNAD Erbay, Güven - Ceyhun, Gökhan. "Relationship between heart rate recovery index and erectile dysfunction". İstanbul Kuzey Klinikleri 8/4 (2021), 371-376. https://doi.org/10.14744/nci.2020.23921