Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity

TERZİOĞLU, Nalan; GÜRSOY, Aysel

Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity

Aysel GÜRSOY, (İstanbul Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Nalan TERZİOĞLU (İstanbul Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Chemistry

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Yıl: 2005 Cilt: 29 Sayı: 3 Sayfa Aralığı: 247 - 254 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity

Öz:

Two regioisomer series, 2-(3-ethyl-4(3H)-quinazolinone-2- ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones (12-21) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylamino)- 5-methyl-4-thiazolidinones (22-26), were synthesized by the cyclization of 1-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetyl)-4-alkyl/aryl thiosemicarbazides (1-11) with ethyl 2-bromopropionate in the presence of anhydrous sodium acetate in anhydrous ethanolic medium. The structures of 12-26 were confirmed by analytical and spectral data (IR, $^1H-NMR$ and EIMS). Selected members of the thiosemicarbazides and thiazolidinones were subjected to anticonvulsant activity tests by the National Institute of Neurological Disorders and Stroke MD, USA.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜRSOY A, TERZİOĞLU N (2005). Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. , 247 - 254.
Chicago	GÜRSOY Aysel,TERZİOĞLU Nalan Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. (2005): 247 - 254.
MLA	GÜRSOY Aysel,TERZİOĞLU Nalan Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. , 2005, ss.247 - 254.
AMA	GÜRSOY A,TERZİOĞLU N Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. . 2005; 247 - 254.
Vancouver	GÜRSOY A,TERZİOĞLU N Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. . 2005; 247 - 254.
IEEE	GÜRSOY A,TERZİOĞLU N "Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity." , ss.247 - 254, 2005.
ISNAD	GÜRSOY, Aysel - TERZİOĞLU, Nalan. "Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity". (2005), 247-254.

APA	GÜRSOY A, TERZİOĞLU N (2005). Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. Turkish Journal of Chemistry, 29(3), 247 - 254.
Chicago	GÜRSOY Aysel,TERZİOĞLU Nalan Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. Turkish Journal of Chemistry 29, no.3 (2005): 247 - 254.
MLA	GÜRSOY Aysel,TERZİOĞLU Nalan Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. Turkish Journal of Chemistry, vol.29, no.3, 2005, ss.247 - 254.
AMA	GÜRSOY A,TERZİOĞLU N Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. Turkish Journal of Chemistry. 2005; 29(3): 247 - 254.
Vancouver	GÜRSOY A,TERZİOĞLU N Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. Turkish Journal of Chemistry. 2005; 29(3): 247 - 254.
IEEE	GÜRSOY A,TERZİOĞLU N "Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity." Turkish Journal of Chemistry, 29, ss.247 - 254, 2005.
ISNAD	GÜRSOY, Aysel - TERZİOĞLU, Nalan. "Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity". Turkish Journal of Chemistry 29/3 (2005), 247-254.