Coenzyme Q10 in Male Infertility
Yıl: 2021 Cilt: 6 Sayı: 1 Sayfa Aralığı: 139 - 147 Metin Dili: İngilizce DOI: 10.5336/healthsci.2020-75062 İndeks Tarihi: 17-02-2022
Coenzyme Q10 in Male Infertility
Öz: Currently the male factor is frequently encountered in the infertility problem. Basically, the factors that cause sperm dysfunction and male infertility are environmental, physiological and genetic. Excessive amount of reactive oxygen species and other oxidant radicals have been associated with male infertility. In addition, although semen analysis parameters appear normal in idiopathic male infertility, it is suggested that the possible cause of infertility is oxidative stress. Antioxidants in foods that are protective against oxidative stress increase the success of assisted reproductive techniques by protecting spermatozoa from free oxygen radicals, preventing DNA breaks caused by free oxygen radicals, and supporting the sperm maturation process. Coenzyme Q10 (CoQ10), which is found in every cell and has the ability to dissolve in oil, is a vitamin-like compound that acts as a coenzyme in key enzymatic reactions in energy production in the cell. Endogenous CoQ10, is significantly associated with sperm count and motility and is shown as one of the most important antioxidants in seminal plasma. Exogenous CoQ10 administration can be explained by its positive effects on sperm motility, its effectiveness in mitochondria and its antioxidant effects. In this review, articles investigating the effect of oxidative stress on infertility and the role of CoQ10, a natural antioxidant vitamin in the treatment of infertility, were presented. As a result, the positive effects of using CoQ10 as a supportive treatment in male infertility have been shown in studies. However, more comprehensive, long-term and pregnancy-related studies are needed.
Anahtar Kelime: Erkek İnfertilitesinde Koenzim Q10
Öz: Günümüzde infertilite problemi içerisinde erkek faktörü sıklıkla karşımıza çıkmaktadır. Temel olarak sperm fonksiyon bozukluğu ve erkek infertilitesine neden olan faktörler çevresel, fizyolojik ve genetiktir. Aşırı miktarda bulunan reaktif oksijen türü ve diğer oksidan radikaller erkek infertilitesi ile ilişkilendirilmiştir. Ayrıca idiyopatik erkek infertilitesinde semen analizi parametreleri normal görünmesine rağmen olası infertilite nedeninin oksidatif stres olduğu öne sürülmektedir. Besinlerde bulunan ve oksidatif strese karşı koruyucu olan antioksidanlar spermatozoayı serbest oksijen radikallerinden koruyarak, serbest oksijen radikallerinin neden olduğu DNA kırılmalarını önleyerek, sperm olgunlaşma sürecine destek vererek yardımcı üreme tekniklerinin başarısını artırmaktadır. Her hücrede bulunan ve yağda çözünebilme özelliğine sahip olan koenzim Q10 (CoQ10), hücrede enerji üretiminde kilit enzimatik reaksiyonlarda koenzim olarak görev yapan vitamin benzeri bir bileşiktir. Endojen CoQ10 sperm sayısı ve hareketliliği ile önemli ölçüde ilişkili olup, seminal plazmada en önemli antioksidanlardan biri olarak gösterilmektedir. Eksojen CoQ10 uygulamasının sperm hareketliliği üzerine olumlu etkilerinin olması, mitokondrideki etkinliği ve antioksidan etkileri ile açıklanabilmektedir. Bu derlemede, oksidatif stresin infertilite üzerindeki etkisini ve infertilite tedavisinde doğal bir antioksidan vitamin olan CoQ10’in rolünü araştıran makaleler incelenmiştir. Sonuç olarak, yapılan çalışmalarda genel olarak CoQ10’in destekleyici bir tedavi olarak erkek infertilitesinde kullanımının olumlu etkileri gösterilmiştir. Ancak, daha kapsamlı, uzun süreli ve gebelikle ilgili sonuçların da değerlendirildiği çalışmaların yapılmasına ihtiyaç duyulmaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | Özturan Şirin A, AKDEVELİOĞLU Y (2021). Coenzyme Q10 in Male Infertility. , 139 - 147. 10.5336/healthsci.2020-75062 |
| Chicago | Özturan Şirin Ayçıl,AKDEVELİOĞLU Yasemin Coenzyme Q10 in Male Infertility. (2021): 139 - 147. 10.5336/healthsci.2020-75062 |
| MLA | Özturan Şirin Ayçıl,AKDEVELİOĞLU Yasemin Coenzyme Q10 in Male Infertility. , 2021, ss.139 - 147. 10.5336/healthsci.2020-75062 |
| AMA | Özturan Şirin A,AKDEVELİOĞLU Y Coenzyme Q10 in Male Infertility. . 2021; 139 - 147. 10.5336/healthsci.2020-75062 |
| Vancouver | Özturan Şirin A,AKDEVELİOĞLU Y Coenzyme Q10 in Male Infertility. . 2021; 139 - 147. 10.5336/healthsci.2020-75062 |
| IEEE | Özturan Şirin A,AKDEVELİOĞLU Y "Coenzyme Q10 in Male Infertility." , ss.139 - 147, 2021. 10.5336/healthsci.2020-75062 |
| ISNAD | Özturan Şirin, Ayçıl - AKDEVELİOĞLU, Yasemin. "Coenzyme Q10 in Male Infertility". (2021), 139-147. https://doi.org/10.5336/healthsci.2020-75062 |
| APA | Özturan Şirin A, AKDEVELİOĞLU Y (2021). Coenzyme Q10 in Male Infertility. Türkiye Klinikleri Sağlık Bilimleri Dergisi, 6(1), 139 - 147. 10.5336/healthsci.2020-75062 |
| Chicago | Özturan Şirin Ayçıl,AKDEVELİOĞLU Yasemin Coenzyme Q10 in Male Infertility. Türkiye Klinikleri Sağlık Bilimleri Dergisi 6, no.1 (2021): 139 - 147. 10.5336/healthsci.2020-75062 |
| MLA | Özturan Şirin Ayçıl,AKDEVELİOĞLU Yasemin Coenzyme Q10 in Male Infertility. Türkiye Klinikleri Sağlık Bilimleri Dergisi, vol.6, no.1, 2021, ss.139 - 147. 10.5336/healthsci.2020-75062 |
| AMA | Özturan Şirin A,AKDEVELİOĞLU Y Coenzyme Q10 in Male Infertility. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021; 6(1): 139 - 147. 10.5336/healthsci.2020-75062 |
| Vancouver | Özturan Şirin A,AKDEVELİOĞLU Y Coenzyme Q10 in Male Infertility. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021; 6(1): 139 - 147. 10.5336/healthsci.2020-75062 |
| IEEE | Özturan Şirin A,AKDEVELİOĞLU Y "Coenzyme Q10 in Male Infertility." Türkiye Klinikleri Sağlık Bilimleri Dergisi, 6, ss.139 - 147, 2021. 10.5336/healthsci.2020-75062 |
| ISNAD | Özturan Şirin, Ayçıl - AKDEVELİOĞLU, Yasemin. "Coenzyme Q10 in Male Infertility". Türkiye Klinikleri Sağlık Bilimleri Dergisi 6/1 (2021), 139-147. https://doi.org/10.5336/healthsci.2020-75062 |
