Infertility is an important problem that has cultural, religious, and social aspects and brings with it biological, psychological, social, ethical, and economic problems. Infertility with its different aspects is thought to affect about fifty to eighty million couples all over the world today. In other words, it affects one out of every ten females worldwide on average, while in Turkey, it affects one out of every six married females. Not only women but also their families, their spouses, the families of their spouses, and many people in their immediate surroundings are affected by this problem. The impact of infertility on relationships rise when a women’s perceptions of their infertility appear, such as the inability to conceive and have children, the inability to satisfy the maternal instinct, the inability to fulfill the role of femininity and the feelings of being isolated from society, being worthless and lonely, having no one to look after them in old age, and lacking a social role. Similar to women, men regard their infertility as the failure to fulfill the role of masculinity, fearing loneliness, the inability to maintain the lineage, and a lack of social security. As a result, this situation influences dyadic adjustment and quality of life negatively with its effects on a couple’s social life, emotional situation, marital relationships, sexual life, plans for the future, self-esteem, and body image. At this stage, nurses play a key role in reducing stress and becoming a key source of information for infertile couples.