Extra-analytical automation is of critical importance in patient safety with respect to accurate, fast test result reporting. Through the previous decades, significant im provements in laboratory errors have been achieved by technological facilities, which have become a substantial part of the reduction of preventable diagnostic errors. In clinical laboratory practice, the total testing process (TTP) is under the effect of error sources: preanalytical, analytical, and post-analytical variables. Since many ex tra-analytical processes within and outside the clinical laboratory may be automated, management of the extra analytical phase can prevent errors, resulting in the total quality of laboratory diagnostics and customer satisfac tion. The automation technologies have added a serious impact on the proficiency of clinical laboratories. To improve standardization, organization, efficiency, and quality of TTP, many manual tasks have now been partially or entirely automated by labor-saving in strumentations. The implementation of extra-analytical automation in the laboratory processes has recently made them standardized and manageable. Depending on the workload and workflow of the clinical laboratory, it is of critical importance to implement adequate systems, providing standardization of the TTP and resulting in high-quality test results.