The Covid-19 pandemic has affected economies differently around the world. Differences in the rate of spread of infection,pandemic restrictions and aid measures, and more importantly, the differences in the economic structure of each region change the dimensions of the economic crisis experienced by sectors, regions, and countries. This study aims to reveal the economic effects of demand shocks arising from the Covid-19 pandemic in the Western Mediterranean Region in Turkey. It is important to determine the expected economic loss in the region, which is highly dependent on one of the most affected sectors during the pandemic process, the tourism sector. In this respect, in the study, the possible effects of demand shocks during the pandemic period on the regional output, sectoral output, and the GDP of the provinces are examined within the framework of scenario analysis with the help of the Input-Output table specially constructed for the region.The changes in the final demand factors such as household demand, investment demand, and exports to and from the region during the pandemic period are calculated with the help of realized data and future assumptions, and scenarios for demand shocks are created. While making predictions regarding demand shocks, the structure of the economy of the region has been taken into account. The results show that the service sectors, especially tourism, are the most affected ones by the pandemic economically. It is found that the economy of the Western Mediterranean Region is seriously affected by the Covid-19 pandemic due to its dependence on the tourism sector.