Background. Injury is the most common cause of preventable morbidity and mortality among children. Theaim of this study was to determine the epidemiological characteristics and trends of injury-related mortality inchildren under five and to provide evidence for future preventive strategies. Methods. Our study was designed as a descriptive cross-sectional study. National under-five mortality datafrom the Death Notification System database, entered between January 1st, 2014, and December 31th, 2017, wasincluded in the study.Results. Among all under-five deaths registered in the system, 2,560 injury-related death cases were included inthe study. Overall, deaths related to injuries accounted for 4.1% of all deaths in children under five years old. Ofall injury deaths, 59.9% of cases were male, 52.7% occurred at home or its close vicinity, and 80.3% were childrenaged 12–59 months. Injury-related under-five deaths were mainly attributed to traffic injuries (36.5%), falls(12.0%), and suffocation (10.2%). Traffic injuries were the most common cause of injury-related deaths both ininfants 0-11 months and children 12-59 months old. The second and third most common causes of injury-relateddeaths among infants 0-11 months were suffocation and falls, while these were falls and drowning in childrenaged 12-59 months, respectively. The injury-related under-five mortality rate dropped from 11.3 per hundredthousand in 2014 to 9.1 in 2017. Causes of all unintentional injury-related deaths were associated with seasonexcept for other unintentional injuries and exposure to mechanical forces (p <0.001). Conclusions. The injury-related mortality rate among children under five years declined from 2014 to 2017,however it is still high. To prevent injuries in children under five, it is important to raise awareness and increasethe supervision of children by their caregivers. At the national level, multisectorial cooperation with a holisticapproach will be of key importance.