ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE

KORKMAZ, NUH; SEVİNDİK, Mustafa; Dayangac, Alpaslan

doi:10.33483/jfpau.977776

ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE

Nuh KORKMAZ, (Osmaniye Korkut Ata Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Osmaniye, Türkiye)

Alpaslan DAYANGAÇ, (Osmaniye Korkut Ata Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Osmaniye, Türkiye)

Mustafa SEVİNDİK (Osmaniye Korkut Ata Üniversitesi, Bahçe Meslek Yüksekokulu, Gıda İşleme Bölümü, Osmaniye, Türkiye)

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

14 1

Yıl: 2021 Cilt: 45 Sayı: 3 Sayfa Aralığı: 554 - 564 Metin Dili: İngilizce DOI: 10.33483/jfpau.977776 İndeks Tarihi: 21-05-2022

ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE

Öz:

Objective: Plants are known to have many biological activities. In this study, the antioxidant, oxidant, antimicrobial and antiproliferative activities of Galium aparine L. were investigated. Material and Method: The antioxidant and oxidant potentials of the plant, the aerial parts of which were extracted with ethanol in a Soxhlet device, were measured using Rel assay kits. Antimicrobial activity against bacteria and fungi was determined using the agar dilution method. Lung carcinoma cell line (A549) was used to determine the antiproliferative activity. Result and Discussion: As a result of the studies, total antioxidant status (TAS) value of plant extracts was determined as 5.147 ± 0.237, total oxidant status (TOS) value as 18.679 ± 0.245 and oxidative stress index (OSI) value as 0.346 ± 0.018. Plant extracts were found to be effective against test microorganisms at concentrations of 50-200 μg/mL. In addition, it was determined that the antiproliferative activity of the plant extract showed potent effects depending on the increase in the extract concentration. Finally, it was determined that Galium aparine has high biological activity and can be used as a natural pharmacological agent in this context.

Anahtar Kelime:

GALIUM APARINE’NİN ANTİOKSİDAN, ANTİMİKROBİYAL VE ANTİPROLİFERATİF AKTİVİTELERİ

Öz:

Amaç: Bitkilerin birçok biyolojik aktiviteye sahip olduğu bilinmektedir. Bu çalışmada Galium aparine L.'nin antioksidan, oksidan, antimikrobiyal ve antiproliferatif aktiviteleri araştırıldı. Gereç ve Yöntem: Toprak üstü kısımları Soxhlet cihazında etanol ile ekstrakte edilen bitkinin antioksidan ve oksidan potansiyelleri Rel test kitleri kullanılarak ölçüldü. Bakteri ve mantarlara karşı antimikrobiyal aktivite, agar seyreltme yöntemi kullanılarak belirlendi. Antiproliferatif aktiviteyi belirlemek için Lung Carcinoma Cell Line (A549) kullanıldı. Sonuç ve Tartışma: Çalışmalar sonucunda bitki ekstraktlarının toplam antioksidan seviyesi (TAS) değeri 5.147 ± 0.237, toplam oksidan seviyesi (TOS) değeri 18.679 ± 0.245 ve oksidatif stres indeksi (OSI) değeri 0.346 ± 0.018 olarak belirlenmiştir. Bitki ekstraktlarının 50-200 μg/mL konsantrasyonlarında test mikroorganizmalarına karşı etkili olduğu bulundu. Ayrıca bitki ekstraktının antiproliferatif aktivitesinin ekstrakt konsantrasyonundaki artışa bağlı olarak güçlü etkiler gösterdiği belirlendi. Sonuç olarak Galium aparinin yüksek biyolojik aktiviteye sahip olduğu ve bu bağlamda doğal bir farmakolojik ajan olarak kullanılabileceği belirlendi

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KORKMAZ N, Dayangac A, SEVİNDİK M (2021). ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. , 554 - 564. 10.33483/jfpau.977776
Chicago	KORKMAZ NUH,Dayangac Alpaslan,SEVİNDİK Mustafa ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. (2021): 554 - 564. 10.33483/jfpau.977776
MLA	KORKMAZ NUH,Dayangac Alpaslan,SEVİNDİK Mustafa ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. , 2021, ss.554 - 564. 10.33483/jfpau.977776
AMA	KORKMAZ N,Dayangac A,SEVİNDİK M ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. . 2021; 554 - 564. 10.33483/jfpau.977776
Vancouver	KORKMAZ N,Dayangac A,SEVİNDİK M ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. . 2021; 554 - 564. 10.33483/jfpau.977776
IEEE	KORKMAZ N,Dayangac A,SEVİNDİK M "ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE." , ss.554 - 564, 2021. 10.33483/jfpau.977776
ISNAD	KORKMAZ, NUH vd. "ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE". (2021), 554-564. https://doi.org/10.33483/jfpau.977776

APA	KORKMAZ N, Dayangac A, SEVİNDİK M (2021). ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 45(3), 554 - 564. 10.33483/jfpau.977776
Chicago	KORKMAZ NUH,Dayangac Alpaslan,SEVİNDİK Mustafa ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 45, no.3 (2021): 554 - 564. 10.33483/jfpau.977776
MLA	KORKMAZ NUH,Dayangac Alpaslan,SEVİNDİK Mustafa ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.45, no.3, 2021, ss.554 - 564. 10.33483/jfpau.977776
AMA	KORKMAZ N,Dayangac A,SEVİNDİK M ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2021; 45(3): 554 - 564. 10.33483/jfpau.977776
Vancouver	KORKMAZ N,Dayangac A,SEVİNDİK M ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2021; 45(3): 554 - 564. 10.33483/jfpau.977776
IEEE	KORKMAZ N,Dayangac A,SEVİNDİK M "ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 45, ss.554 - 564, 2021. 10.33483/jfpau.977776
ISNAD	KORKMAZ, NUH vd. "ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 45/3 (2021), 554-564. https://doi.org/10.33483/jfpau.977776